Alirocumab
Buy Praluent Online from Canada
Praluent (alirocumab) is a prescription medication used to manage high cholesterol and reduce cardiovascular risk. It works by inhibiting PCSK9 protein, enhancing the liver’s ability to remove LDL cholesterol. Administered as a subcutaneous injection every two weeks or monthly, Praluent is particularly effective for individuals with familial hypercholesterolemia or those who cannot tolerate statins. Common side effects include sinus blockage, UTIs, and common cold symptoms.
Product Overview
Praluent (alirocumab) is a targeted medication primarily prescribed for the management of high cholesterol levels and the reduction of cardiovascular risks in adults. It operates by blocking the PCSK9 protein, which normally limits the liver’s capacity to clear LDL cholesterol—often termed “bad cholesterol”—from the bloodstream. As a result, Praluent efficiently lowers LDL levels and is commonly used alongside diet and maximally tolerated statin therapy.
This medication is especially beneficial for patients with heterozygous familial hypercholesterolemia (HeFH) and those who either cannot tolerate statins or find statins insufficient. Praluent is administered through a subcutaneous injection, typically every two weeks, with a monthly dosing option available based on individual needs and doctor’s advice.
Side effects are generally mild but can include sinus blockages, urinary tract infections, common cold symptoms, muscle pain, and injection site reactions. For best results, it’s critical to follow prescribed dosages and administration guidelines closely. Praluent does not have FDA-boxed warnings, indicating a favorable safety profile, though patients should discuss potential risks and benefits with their healthcare provider.
What Are the Uses of Praluent?
Praluent is used in:
- Managing High Blood Cholesterol
- Reducing Cardiovascular Risk
- Lowering Additional LDL-C
What Are the Benefits of Praluent?
- Significantly lowers LDL (bad) cholesterol levels in adults with high cholesterol.
- Reduces the risk of heart attack, stroke, and unstable angina requiring hospitalization in adults with cardiovascular disease.
- It can be used in addition to diet and maximally tolerated statin therapy.
- Effective for patients with heterozygous familial hypercholesterolemia (HeFH).
- Administered as a subcutaneous injection, typically every two weeks or monthly.
- Offers flexible dosing options to meet individual patient needs.
- It may be used in patients who cannot tolerate statins or for whom statins are not sufficiently effective.
- Targets PCSK9 protein, offering a different mechanism of action compared to statins.
- Can help patients reach their LDL cholesterol goals when other treatments have failed.
- Shows consistent efficacy across various patient subgroups.
- Generally well-tolerated with a favorable safety profile.
- May reduce the need for LDL apheresis in some patients with severe hypercholesterolemia.
What Are the Side Effects of Praluent?
Common Praluent side effects may include:
- Blocked sinus
- UTI (urinary tract infection)
- Common cold. Its signs may include:
- Muscle pain or cramp
- Fever
- Bruising
- Fatigue
- Diarrhea
- Sore throat
- Swelling or pain at the injection site
- Body ache
- Itching
- Sneezing
- Runny nose
- Skin redness/discoloration
[Note: This list is not exhaustive, if you notice any other symptoms not mentioned above, consult your doctor immediately.]
Praluent Dosage
What Are the Forms & Strengths of Praluent?
Praluent comes as a liquid solution used in a pre-filled, single-dose pen. Its strengths are:
- 75 mg/ml
- 150 mg/ml
What Are the Recommended Dosages of Praluent?
Reducing Cardiovascular Risk
- Standard Dosage: Start with a 75-mg injection every two weeks.
- Monthly Option: If bi-weekly injections are not suitable, consider a 300-mg dose every four weeks.
- Adjustments: LDL levels will be checked 4-8 weeks after starting treatment. If levels remain high, the dose may be increased to 150 mg every two weeks or 300 mg every four weeks, as needed.
Lowering LDL Cholesterol in Primary Hyperlipidemia
- The dosage guidelines for primary hyperlipidemia are consistent with those for reducing cardiovascular risk.
Heterozygous Familial Hypercholesterolemia (HeFH)
- For adults undergoing LDL apheresis to manage cholesterol, the recommended dosage is a 150-mg injection every two weeks.
How to Take Praluent?
- Before administering, read the medication guide given by your healthcare provider or pharmacist. Follow all prescribed instructions carefully.
- Remove Praluent from the refrigerator and let it warm to room temperature for 30 to 40 minutes before use. Do not shake the medication.
- Praluent is a subcutaneous injection, meaning it is injected under the skin. Typical injection sites include the top of the thigh, the abdomen (avoiding a two-inch area around the navel), and the outer side of the upper arm. Rotate the injection sites to avoid irritation.
- If you use other injectable medications, such as insulin, do not inject Praluent in the same area.
What to Do When You Miss a Dose of Praluent?
- Try not to miss a dose. If you do miss one, take it as soon as you remember within 7 days.
[Note: Do not simultaneously take two doses of Praluent to compensate for a missed dose. This can increase your risk of experiencing side effects.]
What Happens When You Overdose on Praluent?
Do not take more than the prescribed dose. If you overdose and experience symptoms like fainting or difficulty breathing, seek emergency medical help or call 911.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Praluent Work?
Praluent works by blocking a protein in the body known as PCSK9, which normally reduces the liver’s ability to remove LDL (bad) cholesterol from the blood. By inhibiting PCSK9, Praluent helps the liver remove more LDL cholesterol, thereby lowering blood levels and reducing the risk of cardiovascular issues like heart attacks and strokes.
Important Safety Precautions
- Praluent does not carry any FDA-boxed warnings, indicating it is generally safe under proper medical guidance. Always follow your healthcare provider’s instructions and report any unusual symptoms.
- Inform your doctor about any allergies to Praluent or its inactive ingredients to prevent allergic reactions.
- Disclose all medications you’re taking to your healthcare provider before any surgery to mitigate side effects.
- Discuss your personal and family medical history to avoid potential complications.
- Avoid excessive alcohol as it can exacerbate liver damage, particularly when combined with statins.
- Pregnancy: The safety of Praluent during pregnancy is uncertain; consult with your healthcare provider to weigh the risks and benefits.
- Breastfeeding: The effects of Praluent on breastfeeding infants are unclear; discuss potential risks with your healthcare provider before breastfeeding.
How to Store Praluent?
- Keep the pre-filled injections refrigerated at a temperature between 2°C and 8°C (36°F and 46°F).
- Store the injections in their original carton to protect them from light.
- Do not keep the injections in damp or moist places like bathrooms or near sinks.
- Avoid direct sunlight and extreme heat.
What Medications Interact with Praluent?
- When Praluent is taken with other medications, it can potentially lead to increased side effects or impact the effectiveness of the medications.
- Although Praluent does not come with specific interaction warnings, be vigilant for any unusual symptoms and discuss them with your healthcare provider if they occur.
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
What Are the Praluent Alternatives?
[Note: Your healthcare provider will choose which Praluent alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Praluent Cost & Coupons
Praluent might not be fully covered by health insurance in the United States, particularly if the prescribed usage doesn’t align strictly with the insurer’s criteria. This can result in high costs for patients who need this life-saving cholesterol medication. However, you can buy Praluent online from Canada at a reduced cost through Arctic Meds, a service that provides American consumers access to Canadian pharmacy prices. To decrease the cost further, utilize a Praluent coupon code offered by Arctic Meds.
Frequently Asked Questions
How long can I use Praluent?
You can use Praluent for as long as your healthcare provider recommends. The length of treatment can vary depending on your specific health needs and how well your body responds to the medication. Regular check-ups with your doctor are important to decide if you need to continue using Praluent to keep your cholesterol levels low and reduce the risk of heart disease.
Can I stop taking Praluent suddenly?
You should not stop taking Praluent suddenly without talking to your healthcare provider. Stopping abruptly can cause your LDL cholesterol levels to rise. Your doctor will guide you on how to stop or adjust your medication if it becomes necessary safely.
How long does Praluent take to work?
Praluent starts to lower LDL cholesterol levels within a few weeks after you begin treatment. You will likely see a significant reduction in your cholesterol levels within 4 to 8 weeks. Your doctor will monitor your progress to see how well the drug is working and make any necessary adjustments to your dosage.
Is Praluent a statin drug?
No, Praluent is not a statin drug. It is classified as a PCSK9 inhibitor, which works differently than statins. While statins primarily work by reducing the production of cholesterol in the liver, Praluent works by blocking the PCSK9 protein, which helps to remove more LDL cholesterol from your blood.
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