SAVE $20 OFF First Orders with Coupon Code: POLARBEARN20

Estradiol to Reduce the Dementia Risk in Postmenopausal Women

buy premarin tablets

The postmenopausal phase represents a major shift in a woman’s life, indicating significant changes in a woman’s body. Besides physical changes like night sweats and hot flashes, etc, this stage of hormonal imbalances has serious effects on mental and cognitive health. To address these problems, hormone therapy, particularly through medications like Estradiol and its alternate option, buy premarin tablets, has shown effective results in managing hormonal imbalances. While prescribed by doctors, these hormonal drugs are said to have certain implications for women’s neurological conditions. 

So, today, we are going to discuss how Estradiol reduces the risk of dementia in postmenopausal women. We will also provide the clinical study supporting the efficacy of Estradiol and outline steps for effectively managing brain health during menopause.

Dementia & Estradiol in Postmenopausal Women: What’s the Connection

Estradiol (a form of estrogen), which lowers after menopause, plays a crucial role in brain functioning. According to a study from the National Library of Medicine, a decline in estrogen levels, specifically Estradiol, significantly increases the risk of Alzheimer’s in postmenopausal women. Dr. Mosconi’s remarks in the New York Times further support this link, indicating the female brain is rich in estrogen receptors, especially in areas controlling memory, mood, sleep, and body temperature. 

These regions function best when estrogen is high and consistent. As women enter the postmenopausal phase, the gradual decline in Estradiol affects brain functioning in these regions, contributing to several menopausal symptoms such as hot flashes, mood disruptions, and a temporary decline in memory and cognition. This evidence is enough to prove that low estrogen can increase the risk of dementia in postmenopausal women.

Effect of Estradiol on Postmenopausal Women: Clinical Study

Exploring the impact of hormone therapy on brain health in postmenopausal women, numerous studies have been conducted, one of which is PLOS ONE. This study conducted by Dr. Natalie Rasgon from Stanford Center for Neuroscience found that women who began taking estradiol therapy within a year of menopause and continued it showed better brain function in memory and thinking areas. On the other hand, stopping Estradiol led to a decrease in brain activity. 

Moreover, when the other hormone, Progestin, was taken with Estradiol and its counterpart, it neutralized Estradiol’s neurological benefits and worsened the decline associated with Premarin .625 tablet. Overall, the study shows the positive effects of Estradiol and how the timely consumption of estrogen can affect brain health in menopausal women. According to the researchers, if the study shows promising results on a major level, estradiol therapy could become a preferred choice for keeping the brain healthy in women after menopause.

Benefits of Estradiol in Postmenopausal Women 

When taken under the supervision of medical professionals, Estradiol offers several benefits in postmenopausal women, which are as follows:

  • Enhanced Cerebral Blood Flow: Estradiol increases cerebral blood flow to the brain, delivering more oxygen and nutrients, which helps the brain function more effectively.
  • Anti-inflammatory Properties: Estradiol has anti-inflammatory effects that protect the brain from swelling and other inflammatory issues.
  • Neurotransmitter Activity: Estradiol boosts the activity and number of neurotransmitters like serotonin, dopamine, and norepinephrine. These chemical messengers are crucial for mood regulation and brain functions like learning and memory.
  • Neuroprotective Effects: Estradiol helps protect the brain from damage caused by oxidative stress, ischemia, and amyloid proteins, which are linked to Alzheimer’s disease. Women taking Estradiol have a reduced risk of developing Alzheimer’s compared to those taking other estrogens like Premarin .625 tablet.

Things to Consider Before Starting Estradiol

To avoid any complication related to your health, you need to be mindful of certain things before you start Estradiol as hormone therapy:

  • Medical History: Keep your healthcare professional informed about your medical history, including any current medical conditions, surgeries, and medications you are taking. You don’t know which medical condition may affect the safety of estradiol hormonal therapy. 
  • Risks and Benefits: Beware of the potential risks and benefits of hormonal medications like Estradiol. While these therapies can offer relief from menopausal symptoms, they can also have downfalls, like the risk of certain cancers or cardiovascular diseases.
  • Regular Monitoring: To assess the effectiveness of your estradiol hormonal therapy, it is important to regularly visit your doctor. Make follow-up appointments and take the recommended tests that your medical professional has requested. 

Steps for Effective Brain Health in Postmenopausal Women

Besides taking hormone therapy like Estradiol, there are 2 ways that can reduce the risk of dementia and enhance overall brain health in postmenopausal women.

Physical Activity: According to the New York Times, physical inactivity is connected to a higher risk of neurodegenerative diseases in women. Additionally, a 2018 study reported by the American Academy of Neurology followed approximately 200 middle-aged women over 44 years. It found that those who were physically fit at the start of the study had a lower chances of developing dementia later in life. Furthermore, Dr. Mosconi’s research indicated that women who were active had healthier brain scans with fewer Alzheimer’s disease markers compared to their less active counterparts.

Healthy Diet: Mediterranean diets, which focus on vegetables, fruits, whole grains, proteins, and healthy fats, have been shown to decrease the risk of dementia, according to the NY Times. The Mediterranean diet, in particular, offers protection to women who are genetically at risk of Alzheimer’s disease. This diet is not only associated with improved cognitive function but also with overall better health outcomes, including reduced incidences of heart disease and stroke. Moreover, the nutrients found in these diets support brain health by reducing inflammation and increasing the levels of protective antioxidants in the body. Additionally, those seeking specific supplements or ingredients that align with the Mediterranean diet can buy drugs from Canada online to ensure they are getting high-quality products.


The journey through postmenopause is linked with significant changes that can impact cognitive health, but there are effective strategies to manage these effects. Hormone therapy, specifically Estradiol, has shown promising results in preserving cognitive health and lowering the risk of dementia in postmenopausal women. While Estradiol may provide various benefits to women in their postmenopausal stage, it is important to consult with a doctor for effective results. Alongside hormone therapy, adopting a healthy lifestyle that includes physical activity and a nutritious diet like the Mediterranean diet can further enhance brain function and overall health.

Scroll to Top