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Repaglinide is an FDA-approved medication that helps control blood sugar levels after meals by promoting early-phase insulin release. The prescription medication is available in tablet form in strengths of 0.5, 1, and 2 mg, to be taken orally, typically thirty minutes before each meal. The medication dosage depends on the patient’s condition and body’s response to treatment. For safe and efficient use of Repaglinide, you should use the medication exactly as directed by your doctor. To ensure the authenticity of the medication, you can buy Repaglinide online from Canada.
Product Overview
Repaglinide, a potent oral antidiabetic medication, is primarily prescribed by your doctor to regulate glucose levels in people with diabetes mellitus type 2. By promoting early-phase insulin release from the beta-islet cells of the pancreas, Repaglinide helps manage postprandial glucose spikes, ensuring effective glycemic control.
Repaglinide is available in tablet form with strengths of 0.5, 1, and 2 mg. It should be taken orally, typically 30 minutes before each meal, 2-3 times a day. Adults are recommended a daily dose of 0.5 to 4 mg before each meal, with a maximum of 16 mg daily. Pediatric use is determined by a doctor based on individual needs and safety. The medication helps manage blood sugar levels by stimulating insulin release, making it an essential tool in diabetes management.
Common side effects of Repaglinide may include diarrhea, weight gain, joint pain, increased appetite, weakness, and rapid heartbeat. Precautions include monitoring for hypoglycemia and sharing your medical history with your doctor. If a dose is missed, take it before the next meal, but never double the dose. Store Repaglinide at a controlled room temperature, away from moisture, heat, and direct light, and out of reach of pets and children. Always follow your healthcare provider’s guidance for optimal results.
Uses of Repaglinide
- It is used to improve glycemic control in individuals with type 2 diabetes mellitus
Benefits of Repaglinide
- Controlling blood sugar levels helps reduce the risks related to diabetes, such as eye problems, kidney damage, and loss of limbs.
- Regulating blood sugar levels helps in leading a healthy and long life.
Side Effects of Repaglinide
Common side effects of Repaglinide may include:
- Diarrhea
- Weight gain
- Joint pain
- Increased appetite
- Weakness
- Rapid heartbeat
[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]
Repaglinide Dosage
Forms & Strengths
It comes in the form of a tablet and has the following strengths:
- 0.5 mg
- 1 mg
- 2 mg
Recommended Dosages
For Type 2 Diabetes Mellitus
- Adults: The daily recommended dose for adults is 0.5 to 4 mg before each meal. Your doctor may make dosage adjustments if required. The maximum maintenance dose is 16 mg daily.
- Pediatric Patients: The safety and efficacy of this medication have not been established in children, so the doctor will determine the usage and dosage upon evaluating the child’s condition, weight, and requirements.
How to Take Repaglinide?
- Before taking the medication, you should carefully read and follow the instructions for use in your patient information leaflet.
- Consult your physician, pharmacist or healthcare provider if you have any queries or concerns about the medication use.
- You should take this medication by mouth thirty minutes before each meal as instructed by your doctor, typically 2-3 times a day.
- The dosage of Repaglinide depends on the condition being treated, your body’s reaction to treatment, and other medications you may be taking.
- Tell your doctor about all your medications, including all prescription, non-prescription, over-the-counter drugs, and herbal supplements you may be taking.
- If switching from a different diabetes medication to Repaglinide, follow your doctor’s instructions carefully to avoid unwanted side effects.
- While receiving treatment with this medication, you should carefully monitor your blood sugar levels and share the reports with your doctor.
- To get the best results from the medication, you should maintain consistency in dosage, and to help you remember it, you should take it around the same time every day.
- Do not share your medications with others, even if they have the same symptoms as you.
Missed Dose
You should take your dose of Repaglinide just before a meal, but do not take it after eating in case you forget to take it at the scheduled time. You may take it at the time scheduled for the next dose. Do not take two doses of the same medication to compensate for the missed dose.
[Note: Do not take two doses of Repaglinide at the same time to compensate for a missed dose. This can increase your risk of experiencing unwanted side effects.]
Overdose
Overdose of Repaglinide may lead to severe hypoglycemia, which can be life-threatening if not treated on time. You can call your doctor or 911. If the person is experiencing adverse symptoms such as trouble breathing, seizures, or loss of consciousness, head to the nearest emergency room. Symptoms of severe low blood sugar (hypoglycemia) may include:
- Changes in vision
- Confusion
- Difficulty speaking
- Excessive sweating
- Seizures
- Stomach pain
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Repaglinide Work?
Repaglinide is an antidiabetic medication used to control high blood sugar in type 2 diabetes. It stimulates insulin release from the beta-islet cells present in the pancreas, which produce insulin, a hormone that helps regulate blood glucose levels. The insulin release triggered by Repaglinide is glucose-dependent, which means it occurs in response to elevated blood glucose levels, especially after meals. Repaglinide works by closing ATP-dependent potassium channels in the beta cells. When these channels close, calcium ions enter the cells, producing insulin secretion.
Important Safety Precautions
- This medication should only be prescribed if a diet plan, exercise, and weight loss control are not sufficient for controlling blood sugar levels and diabetes symptoms.
- Repaglinide, like other medications that increase insulin release, can cause hypoglycemia. Using Repaglinide in combination with metformin increases the risk of severely low blood sugar levels.
- If your body is experiencing stress due to fever, trauma, surgery, or infection, you may have fluctuating blood sugar levels.
- You should not take this medication if you have a known hypersensitivity reaction to Repaglinide or its ingredients.
- Before taking this medication, share your complete medical history with your doctor, especially if you have diabetic ketoacidosis or severe liver disease.
- Repaglinide may interact with certain medications, such as clopidogrel, cyclosporine, gemfibrozil, and NPH insulin, and cause fatal reactions. You should tell your doctor about all your medications, including prescription, non-prescription, over-the-counter, and herbal supplements.
- It is still unknown if Repaglinide is safe for use during pregnancy or breastfeeding, so it is crucial to consult a licensed healthcare professional before taking this medication in this condition.
Storage
- Keep Repaglinide in a tightly closed container at a controlled room temperature, away from direct light, moisture, and excess heat.
- Do not keep it in the bathroom.
- Keep all medications, including Repaglinide, in a safe place, away from the sight and reach of children.
- Do not keep medications that are outdated or no longer needed. Discard them safely.
- For more information on safely disposing of unwanted medications, contact your pharmacist, healthcare provider, or local waste management company.
Repaglinide Interactions
- Azole antifungals
- Beta-blockers
- Clopidogrel
- Corticosteroids
- Gemfibrozil
- Macrolide antibiotics
- Psychiatric medicines
- Rifamycins
- Trimethoprim
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions or supplements.]
Repaglinide Alternatives
- Januvia (sitagliptin)
- Metformin
- Mounjaro (tirzepatide)
- Ozempic (semaglutide)
- Rybelsus (semaglutide)
- Victoza (liraglutide)
- Glucophage (metformin hydrochloride)
[Note: Your healthcare provider will choose which Repaglinide alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
How does Repaglinide compare to other diabetes medications?
Repaglinide is unique in its ability to quickly stimulate insulin release, making it particularly effective for managing postprandial blood sugar spikes. Unlike some other medications, Repaglinide’s effect is short-lived, reducing the risk of prolonged hypoglycemia. It’s often prescribed for patients who need rapid control of mealtime glucose levels.
Can Repaglinide be used in combination with other diabetes medications?
Repaglinide is often used with other antidiabetic medications, such as metformin, to enhance glycemic control. However, combining it with certain drugs can increase the risk of hypoglycemia. It’s essential to consult your physician or healthcare provider to decide the best combination therapy for individual needs and adjust dosages accordingly.
What should I do if I experience severe hypoglycemia while taking Repaglinide?
If you experience severe hypoglycemia, symptoms may include confusion, seizures, or loss of consciousness. Immediate steps include consuming a fast-acting carbohydrate, such as glucose tablets, and seeking medical attention. In emergency cases, contact 911 or go to the nearest emergency room. Regular monitoring and adjusting your dose under a doctor’s supervision can help prevent severe episodes.
Are there any dietary restrictions while taking Repaglinide?
While on Repaglinide, it’s crucial to maintain a consistent meal schedule to match medication timing, typically taken 30 minutes before meals. Do not skip meals as it may lead to hypoglycemia. Discuss with your healthcare provider any specific dietary restrictions, especially concerning carbohydrate intake, to ensure optimal blood sugar management and prevent adverse effects.
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