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Rivaroxaban
Buy Xarelto Online
Xarelto is a potent anticoagulant used to prevent and treat blood clots in conditions like atrial fibrillation, deep vein thrombosis, and orthopedic surgeries. It offers simplified once-daily dosing and does not require routine blood monitoring. Xarelto reduces the risk of stroke and major cardiovascular events, although it must be managed carefully to mitigate the increased risk of bleeding, especially before surgeries or other medical procedures.
Product Overview
Xarelto is a leading anticoagulant medication, often referred to as a blood thinner, designed to prevent and treat blood clots that can cause severe health complications such as stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE). It operates by inhibiting Factor Xa, a key enzyme in the blood coagulation process, thereby reducing the blood’s ability to form clots. Xarelto is valued for its ease of use, requiring no routine blood monitoring and offering a simple once or twice-daily dosing that can be taken with or without food.
Xarelto is particularly effective following orthopedic surgeries, such as knee or hip replacements, to prevent blood clots and reduce the risk of major cardiovascular events in patients with chronic conditions. Due to increased bleeding risks, patients must consult their healthcare provider before discontinuing or starting Xarelto, especially when preparing for surgeries or dental procedures. Xarelto’s comprehensive treatment profile makes it a preferred choice in managing clot-related health risks.
Uses of Xarelto
- Prevention of Stroke
- Treatment of Deep Vein Thrombosis (DVT)
- Treatment of Pulmonary Embolism (PE)
- Preventing Blood Clots Post Hip or Knee Replacement Surgery
- Reducing the Risk of Major Cardiovascular Events
- Prophylaxis in Acutely Ill Medical Patients
Benefits of Xarelto
- Reduces Risk of Blood Clots
- No Routine Monitoring
- Post-Surgical Benefits
- Reduced Risk of Major Bleeding
Side Effects of Xarelto
Common Xarelto side effects may include:
- Bleeding
- Bruising
- Headache or Dizziness
- Pain in the limbs
- Itching
- Gastrointestinal Issues
[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]
Xarelto Dosage
Forms & Strengths
Xarelto has four tablet strengths: 2.5 mg, 10 mg, 15 mg, and 20 mg. Additionally, a liquid suspension form is available at a concentration of 1 mg per milliliter (mg/mL).
Recommended Dosages
Stroke and Systemic Embolism Prevention for Nonvalvular Atrial Fibrillation:
- Typically, 20 mg once daily with the evening meal.
Managing Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE):
- Initially, 15 mg twice daily with food for the first 21 days.
- After the initial period, 20 mg once daily with food for continued treatment and prevention of recurrence.
Prevention of DVT and PE in Patients Undergoing Knee or Hip Replacement Surgery:
- Knee Replacement Dosage: Administer 10 mg of Xarelto once a day for a duration of 12 days.
- Hip Replacement Dosage: Administer 10 mg of Xarelto once daily for 35 days.
Decreased Risk of Major Cardiovascular Events for Coronary Artery Disease (CAD) & Peripheral Artery Disease (PAD)
- 2.5 mg twice daily, taken with aspirin 75-100 mg once daily.
DVT Prevention for Acutely Ill Hospitalized Patients:
- 10 mg once daily (patients should not have a high risk of bleeding).
- Treatment duration typically ranges from 31 to 39 days.
How to Take Xarelto?
- Take Xarelto exactly as your healthcare provider prescribes, typically once or twice a day.
- Xarelto can be taken with or without food, except for the 15 mg and 20 mg tablets, which should be taken with food.
- Take the medication simultaneously each day to maintain even levels in your blood.
- Do not crush, chew, or break the Xarelto tablet. Swallow it whole with water.
- If you miss a dose, take it as soon as you remember on the same day. Do not double up on doses the next day.
- Do not stop taking Xarelto without talking to your healthcare provider, as this may increase your risk of blood clots.
Missed Dose
If you miss a dose of Xarelto, take it as soon as you remember on the same day. Do not double the next day’s dose to catch up. For twice-daily dosing, skip the missed dose if it’s almost time for the next one.
[Note: Do not simultaneously take two doses of Xarelto to compensate for a missed dose. This can elevate your risk of experiencing side effects.]
Overdose
An overdose of Xarelto can increase the risk of severe bleeding. If an overdose of Xarelto occurs, seek immediate medical attention. There is no specific antidote for rivaroxaban; however, treatment focuses on controlling bleeding and may involve the use of blood products or other interventions.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Xarelto Work?
Xarelto targets and inhibits Factor Xa, a crucial enzyme in the coagulation cascade that helps blood clot. By blocking Factor Xa, Xarelto effectively reduces the blood’s ability to form clots. This mechanism of action helps prevent the development of potentially harmful clots in the arteries and veins, which can lead to stroke, deep vein thrombosis (DVT), pulmonary embolism (PE), and other severe conditions.
Important Safety Precautions
- Avoid activities that could result in a fall or injury, as Xarelto increases the risk of bleeding.
- While routine blood monitoring isn’t required, regular check-ups with your healthcare professional are crucial to assess effectiveness and safety.
- Be alert for symptoms like abnormal bruising, prolonged cut bleeding, increased menstrual bleeding, urine that is pink or brown, stools that appear red or black, or coughing up blood.
- Always inform doctors, dentists, or surgeons that you are taking Xarelto before any medical or dental procedure.
- Do not stop Xarelto without consulting your doctor, as it can lead to increased blood clot risks.
- Be cautious with medications such as NSAIDs, other anticoagulants, and supplements like St. John’s Wort, as they can interact with Xarelto.
- Before taking Xarelto during pregnancy or while breastfeeding, seek advice from your healthcare provider.
Storage
- Store Xarelto at an average temperature of 68°F and 77°F.
- Keep the medication dry and away from moisture; avoid storing it in bathrooms.
- Maintain Xarelto in its original packaging to shield it from light until use.
- Place Xarelto out of reach and in the sight of children to prevent accidental ingestion.
- Avoid exposing Xarelto to extreme temperatures, including freezing or excessive heat.
- Always check the package for the expiration date and ensure not to use the medication after it expires.
Xarelto Interactions
- Increased Bleeding: Drugs such as aspirin, clopidogrel, and ibuprofen can elevate bleeding risks.
- Antifungal Interaction: Drugs like ketoconazole and itraconazole may raise Xarelto levels in the blood, enhancing the risk of bleeding.
- HIV Medications: Some antiretroviral drugs, like ritonavir, can also increase Xarelto levels.
- Rifampin: This antibiotic can decrease the effectiveness of Xarelto by reducing its blood levels.
- Anticoagulants, Such as warfarin or heparin, can significantly increase the risk of bleeding when used with Xarelto.
- St. John’s Wort: This herbal supplement can reduce the effectiveness of Xarelto by lowering its blood levels.
- Other CYP3A4 Inducers and Inhibitors: Drugs that affect the CYP3A4 enzyme can alter the effectiveness of Xarelto, either increasing or decreasing its action.
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
Xarelto Alternatives
- Coumadin (warfarin)
- Eliquis (apixaban)
- Pradaxa (dabigatran)
- Savaysa (edoxaban)
- Lovenox (enoxaparin)
- Fragmin (dalteparin)
- Arixtra (fondaparinux)
- Aspirin (acetylsalicylic acid)
- Plavix (clopidogrel)
- Brilinta (ticagrelor)
- Effient (prasugrel)
[Note: Your healthcare provider will choose which Xarelto alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
Is Xarelto considered a blood thinner or an anticoagulant?
Xarelto is classified as an anticoagulant, which is often referred to as a blood thinner. While “blood thinner” might suggest these drugs thin the blood, they do not change its thickness. Instead, anticoagulants like Xarelto reduce the blood’s ability to form clots.
Can Xarelto affect my liver or cause liver damage?
Xarelto is not commonly associated with liver damage, as liver-related side effects were not reported during clinical trials. Post-market observations have reported liver-related problems in some individuals taking Xarelto, including liver damage, hepatitis (liver inflammation), and jaundice (a condition where the skin and the whites of the eyes turn yellow).
Can I continue taking Xarelto if I need a dental extraction?
If you have a dental extraction planned, you may need to temporarily stop taking Xarelto to minimize the risk of heavy bleeding during the procedure. It’s essential to consult your doctor and dentist before the extraction. They may advise stopping Xarelto at least 24 hours before specific dental procedures to manage bleeding risks effectively.
Is it safe to continue taking Xarelto if I’m scheduled for a colonoscopy?
Whether to continue Xarelto before a colonoscopy depends on your doctor’s advice; during a colonoscopy, where a camera on a flexible tube is used to examine the bowel, there is a minor risk of bleeding, especially if tissue samples are taken, or polyps are removed. Since Xarelto inhibits blood clotting and increases bleeding risk, your doctor might suggest stopping it temporarily before the procedure.
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