Fluticasone / Umeclidinium / Vilanterol
Buy Trelegy Ellipta Online
Trelegy Ellipta offers comprehensive relief for adults with COPD, involving chronic bronchitis and emphysema. In one daily dose, this inhaler combines three medications—fluticasone furoate, umeclidinium, and vilanterol. It reduces inflammation, relaxes airway muscles, and improves lung function to alleviate symptoms like coughing and shortness of breath. Trelegy Ellipta also helps prevent COPD exacerbations, ensuring effective long-term management without requiring multiple inhalers.
Product Overview
Trelegy Ellipta is a comprehensive treatment option designed for adults with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. In a single, convenient inhaler, this inhalation powder combines three potent medications, fluticasone furoate, umeclidinium, and vilanterol.
Fluticasone furoate, a corticosteroid, reduces airway inflammation, while umeclidinium is an anticholinergic to relax muscles around the airways. Vilanterol, a long-acting beta-agonist, enhances lung function by dilating the airways, easing breathing, and reducing symptoms like coughing and shortness of breath.
Trelegy Ellipta not only provides effective symptom relief but also helps prevent exacerbations (flare-ups) of COPD, which can result in serious complexity if untreated. It’s administered once daily, simplifying treatment adherence. However, users should follow necessary safety precautions, including avoiding sudden symptom relief with this medication and using a rescue inhaler. Regular monitoring for side effects, such as common cold symptoms or headaches, is advised.
Uses of Trelegy Ellipta
- Treatment of chronic obstructive pulmonary disease (COPD)
- Maintenance therapy for adults with COPD, including chronic bronchitis and emphysema
- Helps improve airflow in the lungs
- Reduces symptoms such as shortness of breath and cough
- Helps prevent exacerbations (flare-ups) of COPD
Benefits of Trelegy Ellipta
- Combines three medications in one inhaler for convenience
- Reduces inflammation in the airways
- Helps relax muscles around the airways
- Improves lung function and airflow
- Decreases symptoms like coughing and shortness of breath
Side Effects of Trelegy Ellipta
Common side effects of Trelegy Ellipta may include:
- Common cold symptoms
- Increased risk in COPD patients
- Headache
- Back pain
- Fungal infection in the mouth or throat
- Sinus inflammation (sinusitis)
- Cough
- Joint pain
- Sore throat
- Constipation
- Urinary tract infection
- Dizziness
- Stomach pain
- Muscle spasms
- Nausea
- Fever
- Taste disturbance
- Mouth or throat pain
- Bruising
- Hoarseness or voice changes
- Fast or irregular heartbeat
- Tremor or shakiness
[Note: This list is not exhaustive; if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]
Trelegy Ellipta Dosage
Forms & Strengths
Trelegy Ellipta is available in the following forms and strengths:
- Inhalation powder for oral inhalation:
- Fluticasone furoate / Umeclidinium / Vilanterol: 100 mcg / 62.5 mcg / 25 mcg per inhalation
Recommended Dosages
COPD Maintenance Dose:
- Take 1 inhalation (or puff) orally once daily.
- Each puff contains 100 mcg of fluticasone, 62.5 mcg of umeclidinium, and 25 mcg of vilanterol.
Asthma Maintenance Dose:
- Take 1 inhalation (or puff) orally once daily.
- Options include puffs containing either 100 mcg/62.5 mcg/25 mcg or 200 mcg/62.5 mcg/25 mcg of fluticasone, umeclidinium, and vilanterol.
How to Take Trelegy Ellipta?
- Hold the inhaler upright and open the cover fully until you hear a click.
- Exhale fully, away from the inhaler, to ensure your lungs are empty.
- Place the inhaler mouthpiece between your lips and seal your lips tightly around it. Inhale steadily and deeply to receive the medication into your lungs.
- Close the inhaler cover firmly after use. Rinse your mouth with water without swallowing after each use to help prevent side effects like thrush.
- Wipe the inhaler mouthpiece with a dry cloth and keep the inhaler in a dry place.
- Use Trelegy Ellipta once a day, simultaneously each day, as prescribed by your healthcare provider.
Missed Dose
If you have missed a dose of Trelegy Ellipta, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
[Note: Do not take two doses of Trelegy Ellipta simultaneously to compensate for a missed dose. This can heighten your risk of experiencing side effects.]
Overdose
An overdose of Trelegy Ellipta can lead to potential systemic effects due to excessive exposure to its components: fluticasone furoate (corticosteroid), umeclidinium (anticholinergic), and vilanterol (long-acting beta agonist). Symptoms may include increased heart rate, tremors, headache, nausea, vomiting, and potentially serious cardiac effects such as arrhythmias or increased blood pressure.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Trelegy Ellipta Work?
Trelegy Ellipta works by combining three medications in one inhaler: fluticasone furoate (a corticosteroid), umeclidinium (an anticholinergic), and vilanterol (a long-acting beta agonist). Fluticasone furoate reduces inflammation in the airways, while umeclidinium relaxes the muscles around the airways. Vilanterol helps open the airways by relaxing the muscles in the lungs. Together, they improve breathing and reduce symptoms in patients with severe COPD.
Important Safety Precautions
- Do not use it for sudden symptoms of COPD or asthma; use a rescue inhaler instead.
- Inform your doctor about all your medications, especially other inhalers or medications for COPD or asthma.
- Monitor for signs of worsening symptoms or allergic reactions (e.g., rash, swelling of face or throat).
- Keep away from children; it is not intended for use in children.
- Do not exceed the prescribed dose; follow the instructions for inhaler use carefully.
- Contact your healthcare provider immediately if you experience chest pain, increased heart rate, or other serious side effects.
- Regularly clean the inhaler as instructed to prevent contamination.
Storage
- Keep in the sealed foil tray until ready to use.
- Only remove from the tray immediately before first use.
- Store at an average temperature (68°F to 77°F or 20°C to 25°C).
- Keep away from heat and direct sunlight.
- Keep out of reach of children.
- Do not refrigerate or freeze.
- Once opened, keep the cover closed when not in use.
- Discard the inhaler 6 weeks after opening the foil tray or when the dose counter reads “0”, whichever comes first.
- Do not use it after the expiration date on the package.
- Keep the inhaler in an upright position.
Trelegy Ellipta Interactions
- Strong CYP3A4 Inhibitors: Drugs like ketoconazole or ritonavir may increase systemic exposure to fluticasone furoate.
- Beta-blockers: They may reduce the effectiveness of vilanterol and potentially lead to severe bronchospasm.
- Anticholinergic Medications: Concurrent use may increase the risk of anticholinergic side effects.
- Monoamine Oxidase Inhibitors (MAOIs): They can potentiate the cardiovascular effects of vilanterol.
- QTc-prolonging Drugs: There may be an increased risk of cardiovascular side effects.
- Steroids: Concurrent use may increase the risk of hypokalemia.
- Sympathomimetic Drugs: They can enhance adrenergic effects when used alongside Trelegy Ellipta.
- Non-potassium-sparing Diuretics: There’s a potential for exacerbating ECG changes or hypokalemia.
- Methylxanthines: They may increase the risk of adverse effects.
- HIV Protease Inhibitors: These can increase systemic corticosteroid effects.
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
Trelegy Ellipta Alternatives
- Advair (fluticasone/salmeterol)
- Symbicort (budesonide/formoterol)
- Breo Ellipta (fluticasone furoate/vilanterol)
- Dulera (mometasone/formoterol)
- Anoro Ellipta (umeclidinium/vilanterol)
- Stiolto Respimat (tiotropium/olodaterol)
- Utibron Neohaler (indacaterol/glycopyrrolate)
- Flovent (fluticasone)
- Pulmicort (budesonide)
- Qvar (beclomethasone)
- Spiriva (tiotropium)
- Incruse Ellipta (umeclidinium)
- Tudorza (aclidinium)
- Serevent (salmeterol)
- Foradil (formoterol)
- Trimbow (beclometasone/formoterol/glycopyrronium)
[Note: Your healthcare provider will choose which Trelegy Ellipta alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
Why is it necessary to rinse my mouth after using Trelegy Ellipta?
Trelegy Ellipta contains fluticasone, an inhaled corticosteroid. Using inhaled steroids can heighten the risk of oral thrush, a mouth fungal infection. Rinsing your mouth with water after each use helps prevent this infection by removing any medication residue that could promote fungal growth.
If my symptoms improve, should I discontinue Trelegy Ellipta?
No, you should not stop using Trelegy Ellipta unless instructed by your healthcare provider. Ceasing medication without guidance can lead to worsening symptoms. If you feel Trelegy Ellipta isn’t effectively managing your condition, discuss with your provider for appropriate adjustments to your treatment plan.
Why does the dose counter on my Trelegy Ellipta inhaler start at 30 when the package states it contains 60 blisters?
The dose counter on Trelegy Ellipta inhalers starts at 30 because it counts the number of doses, not the number of blisters. Each dose of Trelegy Ellipta consists of two blisters: one blister contains fluticasone, and the other contains umeclidinium and vilanterol. Therefore, although the inhaler contains a total of 60 blisters (30 doses), you’re inhaling 2 blisters per dose to receive all three medications.
What are COPD flare-ups?
COPD flare-ups, also known as exacerbations, refer to sudden worsening of symptoms in individuals with Chronic Obstructive Pulmonary Disease. These episodes often require intensified treatment, possibly including steroids or antibiotics. Severe flare-ups may necessitate emergency medical care or hospitalization. They can lead to lasting lung damage, underscoring the importance of early recognition and prevention through awareness of symptoms and prompt medical intervention.
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