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Insulin Glargine

Toujeo Solostar

Toujeo Solostar, an FDA-approved long-acting insulin pen, contains Insulin Glargine to regulate blood sugar levels in adults with diabetes mellitus. It managesIt’s type 1 and type 2 diabetes by mimicking natural insulin action. Available in 300 units/ml strength, it’s administered subcutaneously, with a dosage tailored by healthcare providers. Side effects may include hypoglycemia and injection site reactions. Caution is advised for those with kidney or liver issues, and vigilance is necessary while driving or operating machinery, especially during hypoglycemic episodes. Missed doses should be taken promptly, but overdoses require immediate medical attention. Toujeo Solostar pens are stored refrigerated before use and at room temperature after opening for up to 28 days, following healthcare provider guidance and warnings.

Product Overview

Toujeo Solostar is an FDA-approved, long-acting insulin pen for treating adult diabetes mellitus. Its active ingredient, Insulin Glargine, regulates blood sugar levels over an extended period. It is primarily used to control blood sugar levels in individuals with type 1 and type 2 diabetes by imitating the action of naturally occurring insulin in the body.

The Toujeo Solostar is 300 units/ml in strength and is available as a pre-filled disposable pen. The dosage should be determined by a healthcare professional based on individual needs. Administration is typically subcutaneous, with injection sites rotating to avoid lipodystrophy. It is suitable for adults diagnosed with diabetes who require long-acting insulin therapy to manage their condition effectively.

While generally well-tolerated, Toujeo Solostar may cause side effects such as hypoglycemia, injection site reactions, and allergic reactions. Patients are advised to monitor blood sugar levels regularly and seek medical attention if experiencing persistent adverse effects. Precautions should be taken in patients with certain medical conditions, such as kidney or liver impairment, and caution should be exercised when driving or operating machinery, especially when experiencing hypoglycemia.

In the event of a missed dose, patients should administer the insulin as soon as possible unless it is nearing the time of the next scheduled dose. Overdose may lead to severe hypoglycemia and requires immediate medical intervention. Toujeo Solostar pens should be stored in the refrigerator before use, but once in use, they can be kept at room temperature for up to 28 days. You should follow the guidance provided by your healthcare provider and read all warnings and instructions included with the medication packaging.

Uses of Toujeo Solostar

  • Diabetes mellitus.

[Important warning: It is not recommended for the treatment of diabetic ketoacidosis.]

How to Use Toujeo Solostar?


Strengths and Forms

Form: Pre-filled disposable pen

Strength: Toujeo Solostar 300 units/ml

Recommended Dosage for Different Patients

For Insulin-Naive Patients with Type 1 Diabetes:

  • A starting dose of 1/3 to 1/2 of the daily insulin dose is recommended. Short-acting insulin should be given during each meal to complete the daily insulin dose, which should be 0.2 to 0.4 units per kilogram of body weight.
  • The maximum glucose-lowering effect may take five days to manifest, and the first dose may not be adequate to cover metabolic needs within 24 hours. 

For Insulin-Naive Patients with Type 2 Diabetes:

  • In the beginning, 0.2 units per kilogram of body weight should be taken once a day.

For Patients with Either Type 1 or Type 2 Diabetes Already on Insulin Therapy:

  • Start Toujeo at the same dose as your long-acting insulin once daily if you are currently on it. To maintain the same level of glycemic control as patients taking Lantus (insulin glargine, 100 units/ml), Toujeo will require a higher daily dose.
  • Start Toujeo at 80% of the total daily dosage of NPH or insulin detemir for patients on twice-daily long-acting or intermediate-acting insulin.
  • During the first few weeks of Toujeo treatment, monitor glucose frequently.

[Note: These Toujeo Solostar dosage recommendations may differ from individual to individual. Discuss it with your healthcare professional, and they’ll decide your dosage accordingly.]

How to Take It?

Here’s a step-by-step guide on how to administer Toujeo Solostar:

Step 1. Make sure you have the correct medication and that it has not expired.

Step 2. Wash your hands thoroughly with soap and water. If necessary, clean the injection site with an alcohol swab and let it dry.

Step 3. Check the Toujeo Solostar pen for any damage or leaks. If you notice anything unusual, do not use it.

Step 4. If this is your first time using the pen or if you haven’t used it in a while, you may need to prime it. This involves dialling a dose and pressing the injection button to release a drop of insulin. Follow the instructions provided with your pen.

Step 5. Dial the dose of insulin prescribed by your healthcare provider and ensure the dose is set correctly.

Step 6. Insert the needle into the injection site at a 90-degree angle (perpendicular to the skin). Press the injection button fully to deliver the dose of insulin.

Step 7. After injecting the insulin, keep the needle in place for a few seconds to ensure the entire dose has been delivered.

Step 8. Carefully remove the needle from your skin. Properly dispose of it in a sharps container.

Step 9. Store the Toujeo Solostar pen according to the manufacturer’s instructions, typically at room temperature (between 59°F and 86°F. Do not freeze it or expose it to high temperatures.

Step 10. Regularly monitor your blood sugar levels as recommended by your healthcare provider to ensure that your diabetes is being adequately managed.

[Note: Your doctor will decide the right amount of Toujeo Solostar for you based on your condition, following guidelines and studies on the drug. They’ll adjust your Pregnyl dosage as needed over time.]

How Does Toujeo Solostar Work?

Toujeo Solostar contains Insulin Glargine, a long-acting insulin analogue. It works by imitating the natural insulin produced by the body. After injection, insulin glargine forms micro precipitates in the fatty tissue under the skin, from which small amounts of insulin are continuously released into the bloodstream over an extended period (up to 24 hours). This steady release helps to regulate blood sugar levels between meals and overnight, providing consistent basal insulin coverage. Toujeo Solostar treats diabetes by controlling high blood sugar levels over time.

Important Safety Information

Side Effects

Common side effects of Toujeo Solostar may include:

  • Low blood sugar levels
  • Injection site reactions (such as redness, itching, or swelling)
  • Weight gain

Mild side effects of Toujeo Solostar may include:

  • Headache
  • Nasopharyngitis (inflammation of the nose and throat)
  • Upper respiratory tract infection
  • Nausea

Adverse side effects of Toujeo Solostar may include:

  • Severe hypoglycemia (requiring assistance from others)
  • Hypokalemia (low potassium levels)
  • Allergic reactions (such as rash, itching, or difficulty breathing)
  • Injection site lipodystrophy (changes in fat tissue at the injection site)
  • Fluid retention or oedema (swelling due to fluid buildup)

[Note: This list may not cover all possible side effects of Toujeo Solostar. Always consult with your healthcare giver for medical advice about side effects.]


Hypoglycemia Risk: Toujeo Solostar can cause hypoglycemia (low blood sugar), especially if the dose is too high, if meals are skipped, or if strenuous exercise is not compensated with additional food intake. Severe hypoglycemia can lead to unconsciousness, seizures, or even death. Patients should be educated on recognizing and managing hypoglycemia.

Adjustment of Dosage: Your dosage may need to be adjusted when initiating or discontinuing concomitant medications, changing meal patterns, during intercurrent illnesses, or changes in physical activity. Close monitoring of blood glucose levels is essential in such situations.

Hypersensitivity Reactions: Toujeo Solostar has been associated with hypersensitivity reactions, including anaphylaxis, angioedema, and generalized skin reactions. If signs of hypersensitivity reactions occur, discontinue Toujeo Solostar and initiate appropriate treatment promptly.

Injection Site Reactions: Insulin therapy may cause injection site reactions such as pain, erythema, pruritus, rash, swelling, or bruising. Rotate injection sites within the same region to reduce the risk of lipodystrophy.

Hypokalemia Risk: Insulin therapy can lead to hypokalemia (low potassium levels) due to the redistribution of potassium from the extracellular space to the intracellular space. Monitor potassium levels and adjust treatment as necessary.

Fluid Retention and Heart Failure: Excessive insulin dosing can cause fluid retention and exacerbate heart failure. Patients with heart failure or renal impairment may be more susceptible to these effects. Use caution and monitor for signs and symptoms of fluid retention.

Hypoglycemia in Elderly Patients: Older people are at increased risk of hypoglycemia due to reduced renal function, altered drug clearance, and increased sensitivity to insulin. Adjust dosage cautiously in elderly patients and monitor closely for hypoglycemia.

Driving and Operating Machinery: Hypoglycemia can impair concentration and reaction time, affecting the ability to drive or operate machinery. Patients should be advised to take precautions to avoid hypoglycemia while performing activities that require mental alertness.

Renal or Hepatic Impairment: Insulin requirements may be altered in patients with renal or hepatic impairment. Monitor blood glucose levels closely and adjust insulin dosage as needed.


  • Toujeo Solostar can lower your blood sugar levels, so be vigilant for signs of low blood sugar (hypoglycemia).
  • If you have kidney or liver problems, discuss them with your doctor. You may need particular adjustments to your Toujeo Solostar dosage.
  • Watch out for signs of allergic reactions, like rash or swelling. Let your doctor know if you experience any.
  • Change where you inject Toujeo Solostar to prevent skin reactions or changes in fat under your skin.
  • If you’re pregnant or breastfeeding, talk to your doctor before using Toujeo Solostar. Your insulin needs may change during this time.
  • Toujeo Solostar’s safety and effectiveness in children need to be established. If your child needs it, consult your doctor.
  • You may be more sensitive to Toujeo Solostar’s effects if you’re older. Your doctor may need to adjust your dosage and monitor you closely.
  • Toujeo Solostar could lower your potassium levels, especially if you have kidney problems or take certain medications. Your doctor will monitor this.
  • If you change your exercise or diet habits, let your doctor know. You may need adjustments to your Toujeo Solostar dosage.
  • Low blood sugar can affect your ability to drive safely. If you feel hypoglycemic, avoid driving until your blood sugar stabilizes.

Toujeo Solostar Contraindications

  • Do not use Toujeo if you are experiencing an episode of hypoglycemia.
  • Toujeo is not suitable for treating diabetic ketoacidosis. 
  • Avoid Toujeo if you are allergic to insulin.
  • Toujeo is not approved for use in children younger than six years old.

Missed Dose

  • If you remember shortly after you missed the dose and there’s still a significant amount of time before your next scheduled dose, go ahead and take it.
  • If it’s almost time for your next scheduled dose, ignore the missed one and take your next dose at the regular time. 
  • Do not double the dose to make up for the missed one.

[Note: If you have missed a Toujeo Solostar dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]


An overdose of Toujeo Solostar can lead to severe hypoglycemia, causing symptoms like shakiness, confusion, and, in extreme cases, loss of consciousness or death.

[Note: If you administered more than the recommended dose of Toujeo Solostar, get medical help immediately or call the Poison Help line at 1-800-222-1222.]


  • Toujeo Solostar should be stored in the refrigerator between 36°F and 46°F. Do not freeze it. If it is accidentally frozen, discard it.
  • An unopened Toujeo Solostar pen can be kept at room temperature for up to 28 days. Avoid exposure to excessive heat or direct sunlight.
  • Keep Toujeo Solostar pens away from direct light in the refrigerator and at room temperature.
  • If a Toujeo Solostar pen has not been opened, keep it in the refrigerator until the expiration date is printed on the label. Once opened, it can be stored at room temperature for up to 28 days.
  • Store Toujeo Solostar pens out of the reach of children and pets.

[Note: Discuss the proper storage and disposal of Toujeo Solostar with your healthcare professional.]

Toujeo Solostar Interactions

  • Amlodipine
  • Aspirin
  • Atorvastatin
  • Carvedilol
  • Fenofibrate
  • Furosemide
  • Gabapentin
  • Glimepiride
  • Humalog (insulin lispro)
  • Humalog KwikPen (insulin lispro)
  • Hydrochlorothiazide
  • Januvia (sitagliptin)
  • Jardiance (empagliflozin)
  • Levothyroxine
  • Lisinopril
  • Losartan
  • Metformin
  • Metoprolol
  • Novolog (insulin aspart)
  • NovoLog FlexPen (insulin aspart)
  • Omeprazole
  • Ozempic (semaglutide)
  • Pantoprazole
  • Rosuvastatin
  • Simvastatin
  • Tramadol
  • Trulicity (dulaglutide)
  • Victoza (liraglutide)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)

[Note: This is not a complete list; there could be other drugs that interact with Toujeo Solostar. Tell your doctor about prescription, over-the-counter medicines, and herbal products.]

Toujeo Solostar Alternatives

[Note: Your doctor will choose the best Toujeo Solostar alternative. Only use these alternative medications after consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

How much time does Toujeo Solostar take to work?

Toujeo SoloStar is a long-acting insulin that works several hours after injection and works evenly for 24 hours. It typically takes about 6 hours to begin its effects after injection, and its impact may last more than 36 hours. Remember to consult your healthcare provider for personalized guidance on using Toujeo. 

How long does an opened Toujeo Solostar pen last?

An opened Toujeo SoloStar pen can be stored at room temperature below 86°F (30°C) and should be used within 56 days. Remember not to store the pen with the needle attached, and always dispose of needles properly in a puncture-proof container.

Can I use an expired Toujeo SoloStar pen?

Do not use your pen after the expiration date. If your Toujeo SoloStar has expired, it’s essential to dispose of it properly and obtain a new one. Using expired insulin can affect its effectiveness and may not provide the desired blood sugar control. Always follow your healthcare provider’s instructions regarding insulin usage and storage.

Can I use the Toujeo SoloStar pen twice a day?

Even though Toujeo SoloStar is usually given once a day, some people may experience better blood sugar control if the dose is split and given twice daily (every 12 hours). Toujeo is particularly beneficial for those who suffer from hypoglycemia in the morning or persistent hyperglycemia at dinner. However, following your healthcare provider’s guidance regarding insulin usage and dosing is essential.

Our Guarantee

At, we assure you the most affordable price when you buy Toujeo Solostar from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently access Toujeo Solostar at a substantial cost, call us at 1-888-779-2193 toll-free.


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