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Buy Synvisc One Injection (Hylan G-F 20) from Canada Online

buy synvisc online
Synvisc from Canada Online

Hylan G-F 20


Synvisc Hylan GF20 Injection is an FDA-approved viscosupplementation treatment containing Hylan G-F 20, a natural glycosaminoglycan prescribed to alleviate knee pain associated with osteoarthritis. They are administered as a single intra-articular injection spaced one week apart, totaling three injections, each containing 2 ml (16 mg) of Hylan G-F 20. It works by supplementing the natural synovial fluid in the knee joint, enhancing joint lubrication, and reducing friction during movement. Patients with knee infections, allergies to bird feathers or egg products, or blood clotting issues should not take Synvisc. Follow your doctor’s advice for missed doses and consult for medical advice about side effects and storage.

Product Overview

Synvisc One Injection is a viscosupplementation treatment containing Hylan G-F 20, a natural glycosaminoglycan used to alleviate knee pain caused by osteoarthritis. It is administered as a single intra-articular injection spaced one week apart, totaling three injections, to provide relief for up to 6 months. Each injection contains 2 ml (16 mg) of Hylan G-F 20 and should only be injected into one knee. 

Synvisc works by supplementing the natural synovial fluid in the knee joint, enhancing joint lubrication and reducing friction during movement, thereby alleviating pain and protecting the knee’s cartilage from further deterioration. It replaces damaged synovial fluid with a substance similar to that found in healthy joints, promoting joint function restoration.

Common side effects of Synvisc One Injection include injection site reactions, muscle pain, trouble walking, fever, chills, nausea, vomiting, headache, dizziness, itching, or skin irritation around the knee. Serious side effects may include joint stiffness, arthralgia, joint swelling, joint effusion, injection site pain, joint warmth, arthropathy, arthritis, and gait disturbance.

Patients should not take Synvisc if they are allergic to bird feathers or egg products, have infections in or around the knee, or have circulation problems or blood clots in the legs. It should not be injected into a vein or artery. The Synvisc syringe is for single use only and should be used immediately after opening. Store Synvisc at room temperature, away from direct sunlight and excessive heat. Follow your doctor’s advice regarding missed doses and overdoses, and consult with your healthcare provider for medical advice about side effects and proper storage.

Uses of Synvisc-One

Synvisc is used to:

  • Treat knee pain caused by osteoarthritis.

How to Use Synvisc-One?


Synvisc is supplied in a 2.25 mL glass syringe containing:

  • 2 ml (16 mg) dose of Hylan G-F 20. 

Recommended Dosage for Synvisc-One

Usual Dosage for Osteoarthritis Knee Pain

Synvisc-One is given as a solitary injection into the joint space spaced one week apart, totaling three injections, to provide relief for up to 6 months. The total dose of 6 mL is to be injected in one knee only. 

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • Synvisc Hylan GF20 knee injection should only be done by a qualified doctor. 
  • It is administered as a single intra-articular injection spaced one week apart, totaling three injections, to provide relief for up to 6 months. 
  • Synvisc one injection is usually given using an 18- to 22-gauge needle. 
  • After properly cleaning and numbing the injection site, the medical professional will inject the Synvisc using the standard technique. 
  • It is important to note that most patients experienced pain relief starting around four weeks after receiving treatment for knee osteoarthritis with Synvisc-One or even as early as one week with Synvisc injection.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Synvisc-One Work?

Synvisc operates through a process known as viscosupplementation, acting as a supplement to the natural synovial fluid within the knee joint. This supplementation is vital in enhancing joint lubrication by increasing the viscosity of the joint fluid. By doing so, Synvisc Hylan GF 20 effectively reduces friction during movement, consequently alleviating pain associated with joint mobility. Furthermore, the gel-like consistency of Synvisc Hylan GF 20 plays a crucial role in safeguarding the knee’s cartilage from further deterioration. 

This protective cushioning effect helps prevent additional wear and tear on the cartilage. Notably, this treatment method involves replacing damaged synovial fluid with a substance found in the healthy joints of individuals aged 18 to 27. This approach addresses existing discomfort and promotes the restoration of joint function, offering patients a comprehensive solution for managing knee pain.

Important Safety Information

Side Effects

Common side effects of Synvisc include: 

  • Injection site reactions 
  • Muscle pain
  • Trouble walking
  • Fever
  • Chills
  • Nausea and vomiting
  • Headache
  • Dizziness
  • Itching or skin irritation around the knee

Serious side effects of Synvisc include: 

  • Arthralgia
  • Joint stiffness
  • Joint effusion
  • Joint swelling
  • Joint warmth
  • Injection site pain
  • Arthritis
  • Arthropathy
  • Gait disturbance

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • You should not take Synvisc if you have an infection in your knee or the area around your knees.
  • Tell your doctor if you are allergic to bird, feathers, or egg products. 
  • Let your doctor know if you have blood clots or circulation problems in your legs. 
  • You should not stand for more than 1 hour and indulge in strenuous activity, jogging, or high-impact sports for at least 48 hours after using Synvisc Hylan GF20 injection. Ask your doctor how long you should wait before resuming these activities.
  • Disinfectants that contain quaternary ammonium salts should not be used to clean the injection spot on the skin. 
  • Synvisc should not be injected into a vein or artery because it may increase the risk of unwanted side effects. 


  • The syringe containing Synvisc Hylan gf 20 is intended for single use. The medication should be used immediately after it has been opened.
  • Do not use Synvisc one injection if it has been opened or damaged. 

Other Important Precautions 

Before taking the medication, let your doctor know if:

  • You are pregnant or planning to get pregnant. 
  • You are breastfeeding a baby 
  • You are less than 21 years of age

Synvisc-One Contraindications

Synvisc one 1x6ml is contraindicated in patients with:

  • Known hypersensitivity to hyaluronan products.
  • Infections in or around the knees.

Missed Dose

  • If you have missed your appointment of Synvisc Hylan GF20 Injection, contact your healthcare provider or doctor to know what should be done next.  

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]


Since this medication is to be given by a medical professional, an overdose of the medication is unlikely to occur. But if you notice any signs of an overdose, tell your doctor immediately.

[Note: If someone you know has accidentally overdosed on the medication, get medical help immediately or call the Poison Help line at 1-800-222-1222.]


  • Store it in original packaging away from direct sunlight or excessive heat at room temperature.
  • Do not freeze the medication.
  • Keep it away from the reach of children.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Synvisc-One Interactions

Medications that interact with Synvisc-one include:

  • benzalkonium chloride topical
  • cetylpyridinium topical

[Note: This isn’t a complete list, and there could be other drugs that interact with Synvisc-one. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Synvisc-One Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Frequently Asked Questions

Who should take Synvisc?

Knee arthroscopy is recommended for individuals, both male and female, aged over 35, experiencing knee pain persisting for 1-3 months, without a history of significant knee injuries or severe arthritis. Synvisc One is an alternative treatment option for patients suffering from knee arthritis, particularly those whose symptoms have not been alleviated through dietary measures. However, it should not be prescribed to children with severe allergic reactions to hyaluronic acid, and it is contraindicated for individuals with swollen joints or cutaneous inflammatory dermatitis.

How long does Synvisc last in synovial fluid?

Synvisc is a sterile, clear, viscous solution containing Hylan G-F 20, a natural glycosaminoglycan produced by your body. Synvisc is used to reduce pain and increase mobility in osteoarthritis patients. It acts as a lubricant in the knee, preventing wear and tear from normal wear and tear. 

Hylan GF 20 is injected into the knee through the patient’s synovial fluid, replacing the damaged hyaluronic acid in the joint. This helps to reduce pain and increase mobility in the joint. Synvisc lasts in the joint for up to 6 months, after which the patient’s joint produces its hyaluronic acid.

Where can I buy Synvisc online?

Online Synvisc injection is available at a discount at our Canadian Pharmacy, where you will find the lowest prices. Online prescription medication is available based on your physician’s prescription at Polar Bear Meds. To buy Synvisc online from a trusted Canadian pharmacy at an affordable Synvisc one injection cost, contact us at 1-888-779-2193 toll-free.

What should I do after the Synvisc injection & what is the timeframe for getting relief?

Following a Synvisc injection, it is advisable to refrain from activities that place excessive strain on the knee, such as jogging, heavy lifting, or prolonged standing, within the initial 48 hours. In case of mild pain or swelling at the injection site, patients can apply an ice pack to the knee for approximately 10 minutes or as per the specific guidance provided by their healthcare professional.

Individual responses may vary regarding the timeline for pain relief after a Synvisc injection. However, according to a clinical study, many patients reported pain relief as early as one month post-injection. Synvisc One has demonstrated the ability to offer relief from knee pain for up to six months. Moreover, it is noteworthy that Synvisc one injections can be safely repeated.

Our Guarantee

At, we assure you the most affordable price to buy Synvisc-One from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently access Synvisc-One at a substantial cost, call us at 1-888-779-2193 toll-free.

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Shipping prices:
Refrigerated items $29.99
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