Sildenafil
What is Sildenafil?
Sildenafil, a prescription medicine approved by the FDA, helps men with erectile dysfunction (difficulty getting or keeping an erection) and pulmonary arterial hypertension (high blood pressure in the lungs). It slows down an enzyme called phosphodiesterase type-5. It comes in tablet and liquid suspension forms for oral consumption, while an intravenous (IV) variant is exclusively administered under medical supervision. So, if you want to buy Sildenafil to treat ED and PAH, you need a prescription from your doctor.
Product Overview
Sildenafil is a versatile medication primarily used for treating erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It belongs to a class of drugs called PDE5 (phosphodiesterase type 5) inhibitors, which function by increasing the flow of blood to different body parts. For ED, sildenafil improves the ability to achieve & keep an erection sufficient for sexual activity by enhancing the blood flow to the penis. PAH reduces blood pressure in the lungs by relaxing blood vessels, improving exercise capacity, and possibly slowing disease progression.
The medication is generally well-tolerated and starts working within 30 minutes to 1 hour. Its effects last up to 4 hours. It is available in multiple strengths, ranging from 20 to 100 mg, allowing for flexible dosing. Patients are advised to follow their primary healthcare giver’s instructions closely, particularly regarding dosages and potential interactions with other medications such as nitrates and alpha-blockers.
Common side effects of sildenafil include flushing, headaches, muscle pain, and gastrointestinal issues, with more severe reactions like vision changes and cardiovascular events in at-risk populations. Users need to be aware of these risks and consult healthcare providers for safe usage. Sildenafil requires careful consideration of medical history, especially for those with cardiovascular conditions, liver issues, or those who use other medications that might interact. It offers a viable solution for managing ED and PAH but must be used under medical guidance to minimize risks and maximize benefits.
Uses of Sildenafil
- Enhances sexual function
- Treat pulmonary arterial hypertension (PAH) & erectile dysfunction
Benefits of Sildenafil
- Effective treatment for erectile dysfunction (ED) & pulmonary arterial hypertension (PAH)
- Helps men achieve and maintain erections
- Improves ability to have successful sexual intercourse
- Increases sexual satisfaction and confidence
- Improves exercise ability in PAH patients
- May slow the progression of PAH
- Generally well-tolerated medication
- Relatively quick onset of action (30-60 minutes)
- Available in multiple dosage strengths
- Lower-cost generic versions are available
Side Effects of Sildenafil
Common side effects of Sildenafil may include:
- Flushing (feeling of warmth)
- Nosebleeds
- Muscle pain, back pain, or pain in arms or legs
- Diarrhea
- Headache
- Nasal congestion
- Changes in color vision
- Sensitivity to light
- Numbness, burning, or tingling in arms, hands, feet, or legs
- Nausea
- Heartburn
[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]
Sildenafil Dosage
Forms & Strengths
It comes in the form of oral tablets and has the following strengths:
- 20 mg
- 25 mg
- 50 mg
- 100 mg
Recommended Dosages
Dosage for Erectile Dysfunction
- Adults (up to 65 years): Take 50 mg once daily, about 1 hour before sexual activity.
- Adults (65 years and older): Take 25 mg once daily, 1 hour before sexual activity.
In both age groups, it can also be taken anywhere from 30 minutes to 4 hours before intercourse.
Dosage for Pulmonary Arterial Hypertension
- Adults: Start with 20 mg taken three times a day. Your doctor might increase the dose up to 80 mg three times daily.
- Children (1 year or older, based on weight): Dosages range from 10 to 20 mg, taken thrice daily.
How to Take Sildenafil?
- Follow your doctor’s instructions closely. To avoid additional side effects, do not take more than the recommended dose.
- Read the medicine’s instructions carefully. If there’s something you don’t understand, ask your doctor to clarify.
- Sildenafil can be taken with or without food.
- For erectile dysfunction: It typically starts working about 30 minutes after taking it and can be effective for up to 4 hours. However, its effectiveness might decrease after the first 2 hours.
- Stick to the prescribed brand. Different brands of the same medication may have varying effects.
Missed Dose
If you have pulmonary hypertension & miss a dose, take it as soon as you remember unless it’s nearly time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Don’t take 2 doses at once to compensate for the missed one. If you often forget doses, consider setting an alarm or consulting your pharmacist for tips on remembering your medication.
[Note: Do not take two doses of Sildenafil simultaneously to compensate for a missed dose. This may increase your risk of experiencing side effects.]
Overdose
Taking an excessive amount of Sildenafil can cause visual disturbances, including difficulty distinguishing between blue and green colors and blurry vision. If you experience or notice any of these symptoms, seek immediate medical attention or contact your doctor for guidance.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Sildenafil Work?
- For erectile dysfunction: Sildenafil enhances blood flow to the penis when you are sexually excited, aiding in achieving and maintaining an erection.
- For pulmonary arterial hypertension: It relaxes the blood vessels in your lungs, which helps decrease blood pressure in these vessels and improves your condition.
Important Safety Precautions
- Do not use Sildenafil if you are allergic to it or taking Riociguat (Adempas) for pulmonary arterial hypertension.
- Avoid using Sildenafil if you take nitrate drugs for heart problems or chest pain, such as isosorbide dinitrate, mononitrate, nitroglycerin, and recreational drugs known as “poppers.”
- If you have had a heart attack, stroke, or significant heart rhythm problems in the past 6 months, consult your doctor to ensure Sildenafil is safe for you.
- Avoid Sildenafil if you have Pulmonary Veno-Occlusive Disease (PVOD), as it can exacerbate heart problems.
- If you have a condition like Peyronie’s disease, Sildenafil could increase the risk of a prolonged erection, which may last more than 4 hours and may require medical intervention.
- Sildenafil may increase the risk of ulcers, stomach bleeding, or small holes in the lining of your digestive system, which can be life-threatening. These complications can occur suddenly, with or without warning signs.
- Consult your doctor to determine if Sildenafil suits you if you have sickle cell anemia.
- Sildenafil could cause sudden vision loss, especially in those with pre-existing heart disease, diabetes, high blood pressure, high cholesterol, or certain eye conditions.
- Smokers and individuals over 50 are at a higher risk and should not use it.
- Consult with your primary healthcare giver before using Sildenafil if you are pregnant or breastfeeding.
Storage
- Store Sildenafil tablets in a closed container at room temperature, away from moisture, excess heat, & direct sunlight.
- Do not freeze the tablets.
- Ensure the medication is kept out of reach of children.
- Follow your healthcare provider’s instructions on how to dispose of expired Sildenafil tablets.
- If you use mixed oral liquid Sildenafil, store it in the refrigerator & discard any unused mixture after 60 days.
Sildenafil Interactions
Below are mentioned some interactions of Sildenafil:
- Nitrates
- Alpha Blockers
- Blood Pressure Medications
- Alcohol
- Medications Affecting Liver Proteins
- Grapefruit Juice
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
Sildenafil Alternatives
- Alprostadil
- Vardenafil
- Avanafil
- Tadalafil
[Note: Your healthcare provider will choose which Sildenafil alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
Is Sildenafil as good as Viagra?
Sildenafil & Viagra are exactly the same medication, with only minor differences in packaging and pill appearance. Both are used to treat erectile dysfunction and should provide noticeable improvements in erections and sexual performance when used correctly.
How long will Sildenafil last?
Sildenafil typically remains effective for about four hours, offering a substantial window during which you can achieve optimal erectile function. It is a phosphodiesterase type 5 inhibitor, which blocks an enzyme in your blood vessels, allowing them to relax & widen, thereby improving blood flow.
Can I take Sildenafil daily?
Yes, it is possible to take Sildenafil daily. However, whether you need or should take it daily depends on individual circumstances. Consult your primary caregiver to determine the most appropriate and tailored regimen for your condition.
Does Sildenafil increase size?
Sildenafil can make your erect penis appear larger than usual during sexual stimulation by increasing blood flow to the penis. This effect temporarily enhances size. However, be aware of a rare side effect involving swelling of the genitals, including the penis.
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