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Serevent Diskus 

Serevent Diskus is a prescription inhaler containing salmeterol, used for asthma and COPD maintenance, and to prevent exercise-induced asthma. It is a long-acting beta2-adrenergic agonist (LABA) that relaxes airway muscles to improve breathing. The recommended dosage is one inhalation (50 mcg) twice daily for adults and children over 4 years. For exercise-induced asthma, one inhalation is taken 30 minutes before exercise. Safety guidelines include using it alongside an inhaled corticosteroid for asthma control and not using it to treat acute asthma attacks. Patients should consult their healthcare provider for proper usage.

Product Overview

Serevent Diskus is a long-acting beta2-adrenergic agonist (LABA) inhaler containing salmeterol as its active ingredient. It is primarily used for the prevention and maintenance of asthma and chronic obstructive pulmonary disease (COPD), and for the prevention of exercise-induced asthma. This FDA-approved medication works by relaxing the muscles in the airways, improving airflow, and making breathing easier.

The medication is available in a powder inhaler form with a strength of 50 mcg per inhalation. Adults and children over 4 years old typically use one inhalation twice daily for asthma and COPD maintenance. For preventing exercise-induced asthma, one inhalation is taken 30 minutes before exercise. Common side effects include headache, flu symptoms, and throat irritation. More severe side effects may include chest pain, fast or irregular heartbeats, and worsening asthma symptoms. 

Patients should follow safety guidelines, such as not using Serevent Diskus to treat an acute asthma attack and consulting a doctor if symptoms worsen. Serevent Diskus should be stored at room temperature, away from moisture and heat. It is important to keep track of the medication’s expiration date and the number of doses remaining. Patients should use it as directed by their healthcare provider and be aware of its contraindications and potential interactions with other medications.

Uses of Serevent Diskus

  • Asthma
  • Chronic obstructive pulmonary disease (COPD)
  • Prevention of exercise-induced asthma

How to Use Serevent Diskus?


Strengths and Forms

Formulation: Powder Inhaler (50 mcg per inhalation)

Recommended Dosage for Different Patients

For Asthma Prevention and Maintenance:

  • Adults: 1 inhalation (50 mcg) two times daily, maximum of twice regular administration.
  • For children under 4 years, safety and effectiveness were not established.
  • Children 4 years and older: 1 inhalation (50 mcg) two times daily, maximum of twice-daily administration.

For COPD Maintenance:

  • Adults: 1 inhalation (50 mcg) twice daily, maximum of twice-daily administration.

For Prevention of Exercise-Induced Asthma:

  • Adults: 1 inhalation (50 mcg) 30 minutes before exercise; do not administer a second dose within 12 hours; not recommended for individuals on twice-daily salmeterol therapy.
  • For children under 4 years, safety and effectiveness were not established.
  • Children 4 years and older: 1 inhalation (50 mcg) twice daily, maximum of twice-daily administration.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

To take Serevent Diskus correctly, follow these steps:

  1. Open the Device: Hold the Serevent Diskus in one hand and place the other hand thumb on the thumb grip. Slide the thumb grip away from you as far as it can go until the mouthpiece emerges and locks into place.
  2. Load the Dose: Keep the device horizontal with the mouthpiece facing you. Move the lever away from you until you hear a click. The device is now prepared for use, and a dose has been loaded.
  3. Exhale: Before putting the mouthpiece in your mouth, exhale fully. Do not exhale into the device.
  4. Inhale the Medication: Place the mouthpiece between your lips and close them around it. Inhale the medicine quickly through your mouth. Remove the device from your mouth and hold your breath for about 10 seconds, or as long as is comfortable, then exhale slowly.
  5. Close the Device: After use, slide the thumb grip back towards you as far as it will go to cover the mouthpiece.
  6. Rinse Your Mouth: After inhaling your dose, rinse your mouth with water and spit it out. This helps reduce the risk of developing oral thrush, a possible side effect of inhaled medications.
  7. Check Dose Counter: Keep track of the number of doses left in the device. The dose counter will indicate when it’s time to replace your Serevent Diskus.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Serevent Diskus Work?

Serevent Diskus (salmeterol) works as a long-acting beta2-adrenergic agonist (LABA). It helps relax and open the airways in the lungs, making breathing easier. Salmeterol does this by stimulating certain receptors in the airways called beta2-adrenergic receptors. When these receptors are activated, they cause the muscles around the airways to relax, which helps to widen the airways and improve airflow. This action helps to prevent asthma attacks and improve breathing in people with chronic obstructive pulmonary disease (COPD). It’s important to note that Serevent Diskus is not a rescue inhaler and should not be used for suddenly occurring breathing issues.

Important Safety Information

Side Effects

Common Side Effects

  • Cough
  • Headache
  • Flu symptoms
  • Throat irritation
  • Joint or muscle pain
  • Stuffy or runny nose

Adverse/Serious Side Effects

  • Hives
  • Dry mouth
  • Chest pain
  • Difficulty breathing
  • Blurred vision
  • Limp feeling
  • Constipation
  • Severe headache
  • Nervousness
  • Increased thirst
  • Leg cramps
  • Increased urination
  • Fruity breath odor
  • Fluttering in the chest
  • Numbness or tingling
  • Muscle weakness
  • Fast or irregular heartbeats
  • Worsening asthma symptoms
  • Swelling of the face, lips, tongue, or throat

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • Do not use Serevent Diskus to treat an ongoing asthma attack.
  • Serevent Diskus may increase the risk of asthma-related death. Use as prescribed and for the duration recommended by your doctor.
  • Follow all instructions for safe use and discuss your risks and benefits with your doctor.
  • When using Serevent Diskus for asthma, it must be combined with an inhaled steroid for long-term control.
  • Seek medical attention if your asthma medications seem less effective.
  • Avoid using a second form of salmeterol or similar inhaled bronchodilators unless advised by your doctor.
  • If your asthma medications are less effective or if your peak flow meter readings are lower than normal, seek medical attention immediately. This could be a sign of a serious asthma attack.


  • Do not use Serevent Diskus if you are allergic to salmeterol or milk proteins.
  • Before using Serevent Diskus, inform your doctor if you have had:
    • Food or drug allergies
    • Heart disease or high blood pressure
    • Epilepsy or other seizure disorders
    • Diabetes
    • Thyroid disorders
    • Liver disease
  • Inform your doctor if you are pregnant or planning to become pregnant, as it is unknown if salmeterol can harm an unborn baby.
  • Consult your doctor about the safety of breastfeeding while using this medication.
  • Serevent Diskus may increase the risk of asthma-related hospitalization in children and teenagers. It should be used with another long-term asthma control medication in these age groups.
  • Do not administer Serevent Diskus to children under 4 years old.

Serevent Diskus Contraindications 

  • Severe allergic reactions to milk proteins or known allergies to the medication or its ingredients.
  • Not to be used as the primary treatment for severe asthma attacks (status asthmaticus) or other acute asthma or COPD episodes that require intensive care.
  • It is not suitable for treating asthma without using a long-term asthma control medication like an inhaled corticosteroid.

Missed Dose

If you miss a dose, skip it and take your next dose at the usual time. Do not take two doses simultaneously. Ensure you refill your prescription before your medication runs out completely.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]


In the event of an overdose, if the individual exhibits severe symptoms such as loss of consciousness or difficulty breathing, dial 911 immediately. Overdose symptoms may include chest pain, rapid or irregular heartbeat, headache, and fainting.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]


  • Keep it at room temperature, away from direct heat and light.
  • Do not store it in the bathroom or areas with high humidity.
  • Keep the inhaler in its original packaging until ready to use.
  • Once opened, follow the instructions for discarding the inhaler after a specified number of doses or after the expiration date, whichever comes first.
  • Keep the inhaler dry and clean at all times.
  • Keep it out of reach of children and pets.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Serevent Diskus Interactions

Beta-Blockers: Medications like propranolol or atenolol can reduce the effectiveness of Serevent Diskus and may worsen breathing problems.

Diuretics: Certain diuretics, especially non-potassium-sparing ones, can increase the risk of low potassium levels when used with Serevent Diskus.

MAO Inhibitors and Tricyclic Antidepressants: These can increase the risk of adverse cardiovascular effects when used with Serevent Diskus.

Other Bronchodilators: Using Serevent Diskus with other long-acting beta2-agonists or short-acting bronchodilators can increase the risk of side effects.

CYP3A4 Inhibitors: Medications that inhibit CYP3A4 enzymes, such as ketoconazole, itraconazole, and ritonavir, can increase the levels of salmeterol in the body and lead to increased side effects.

[Note: This isn’t a complete list, and there could be other drugs that interact with Serevent Diskus. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Serevent Diskus Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Does Serevent Diskus contain steroids?

No, Serevent Diskus does not contain steroids. It’s a different type of medication called salmeterol, which is in a group of drugs known as long-acting beta-agonists (LABAs). LABAs work by relaxing the muscles in your airways, making it easier for air to get into your lungs. Unlike some other asthma medications that contain steroids, you don’t need to rinse your mouth after using Serevent Diskus. This is because it works directly on your airways to help you breathe easier without the steroid-related side effects that require mouth rinsing. Remember, it’s important to use it exactly as prescribed by your doctor for the best results.

When is the best time to take salmeterol?

Salmeterol is inhaled as a dry powder using a special inhaler. It’s commonly used to manage asthma or COPD. The best time to take it is twice daily, once in the morning and once in the evening, ideally about 12 hours apart. It’s important to use salmeterol simultaneously each day to maintain its effectiveness. Timing consistency helps control your symptoms and ensures the medication works properly. Remember, regular use as your doctor prescribes is key to managing your condition effectively.

Can I use Serevent Diskus (salmeterol) as my sole inhaler?

If you are taking Serevent Diskus (salmeterol) for asthma, it should not be your only inhaler. Your healthcare provider will also prescribe a steroid inhaler for use alongside Serevent Diskus (salmeterol). However, if you are using this medication to prevent asthma before exercise or for treating COPD, it may be your only inhaler.

How should I store and maintain my Serevent Diskus (salmeterol) inhaler?

Store the Serevent Diskus inhaler at room temperature in a dry place, away from direct sunlight. It does not require refrigeration. The inhaler does not need cleaning. Once opened, the inhaler has an expiration date of 6 weeks and contains enough doses for 30 days. Dispose of the inhaler when the dose counter reads “0” or 6 weeks have elapsed since opening, whichever comes first.

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