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Prucalopride

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Prucalopride is an FDA-approved medication used to manage constipation symptoms like bloating and discomfort. This prescription drug helps relieve constipation, including chronic idiopathic constipation that lasts for three months and has no known cause. This medication can be used in adults, including senior patients, but the dosage can differ depending on the patient’s body requirements and the severity of their medical condition. Therefore, patients should be mindful of the doses they are taking.

Product Overview

Prucalopride is a highly effective medication used to treat chronic idiopathic constipation. It contains the active ingredient prucalopride, a selective serotonin (5-HT4) receptor agonist that enhances bowel movement. FDA-approved and available only by prescription, Prucalopride stands out for its efficacy and safety, providing relief for those struggling with persistent constipation.

Available in tablet form, Prucalopride is typically offered in strengths of 1 and 2 mg. It is taken once daily, with or without food. Suitable for adults, including the elderly, it stimulates the colon’s muscles, promoting more frequent and complete bowel movements. This mechanism helps alleviate symptoms such as bloating, straining, and discomfort, improving patients’ overall quality of life.

While Prucalopride is generally well-tolerated, some individuals may experience side effects, which may include headache, nausea, abdominal pain, or diarrhea. It is important to consult with a healthcare provider before starting Prucalopride, especially for those with a history of severe gastrointestinal disorders. This medication should be stored at room temperature, away from moisture and heat, and kept out of reach of children.

Uses of Prucalopride

This drug is indicated for treating chronic constipation in adults.

Benefits of Prucalopride

Here are some of the benefits of Prucalopride:

  • Improves Bowel Movements: Prucalopride effectively treats chronic idiopathic constipation by enhancing bowel movements.
  • Increases Colonic Motility: It stimulates colonic motility by acting on serotonin (5-HT4) receptors, promoting frequent and complete bowel movements.
  • Reduces Symptoms of Constipation: It helps reduce common symptoms of constipation, such as bloating, straining, and discomfort.
  • Safe for Long-term Use: It is generally well-tolerated and safe to manage chronic constipation.
  • Once-Daily Dosing: Prucalopride is taken once daily, making it convenient and easy to adhere to.
  • Suitable for Various Age Groups: It is effective in adults, including the elderly, and can be used by both men and women with chronic constipation.

Side Effects of Prucalopride

Common side effects of Prucalopride may include:

  • Stomach pain
  • Gas 
  • Bloating
  • Nausea
  • Diarrhea
  • Dizziness
  • Headache
  • Low energy
  • Vomiting
  • Allergic reactions

[Note: This list is not exhaustive; if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]

Prucalopride Dosage

Forms & Strengths

It comes in the following forms and strengths:

  • Tablet: 1 and 2 mg

Recommended Dosages

The usual starting dose of Prucalopride for managing chronic idiopathic constipation is 2 mg, taken once a day. This dose is also considered the maximum dose of the drug. However, if a patient has severe kidney disease, doctors may prescribe a lower dosage of Prucalopride to avoid any complications.

How to Take Prucalopride? 

  • Ensure you read the patient information leaflet properly before taking the medication. 
  • Follow the dosing schedule exactly as your doctor prescribes.
  • Take the medication by mouth once daily, usually with or without a meal, as instructed by your medical provider.
  • Swallow the tablets with a glass of water unless directed otherwise.
  • Do not chew, crush, break, or split the medication unless your doctor advises otherwise. Doing so can release all the drugs at once.
  • You can talk to your physician if you cannot swallow your tablets. They will suggest some alternate options or changes to your treatment.  
  • Take each medication at the same time regularly for effective results.
  • Do not exceed or subceed the recommended doses without consulting a medical professional.
  • Talk to an expert if your condition does not improve in 3 or 4 days. They may recommend additional medication for quick results.

Missed Dose 

  • Take the missed dose as soon as possible or whenever you remember.
  • If it is almost time for the next you, omit the skipped dose and continue following your regular dosing schedule.
  • Avoid taking extra doses to catch up for the missed dose.
  • Use medication apps or phone reminders to avoid skipping any doses.

[Note: Do not take two doses of Prucalopride at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]

Overdose

If someone has mistakenly overdosed on Prucalopride, they may notice a few unusual symptoms. If such signs are visible, patients should immediately seek medical assistance. Following are some of the overdose symptoms that patients need to be mindful of:

  • Vomiting
  • Diarrhea
  • Headache
  • Nausea

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Prucalopride Work?

Muscles in your intestines contract and relax, which helps move food through the digestive system. This process of contraction and relaxation is called peristalsis, and when these movements work efficiently, peristalsis helps in bowel movements. However, if the movements are too slow or are not contracted enough, you may experience constipation. So, when you take Prucalopride, it relieves constipation by increasing muscle contractions and relaxations. The drug gets attached to specific receptors of the intestine’s lining, making the nerve cells release chemicals. This whole process helps the digestive muscles to tighten, thus increasing the movement and helping the food move through the system.  

Important Safety Precautions 

  • Patients have reported suicidal thoughts while using this medication. So, if you have any personal or family history of severe suicidal thoughts, behavior, and depression, consult with a medical professional before using Prucalporide.
  • Avoid using this medication if you have a bowel blockage or a stomach/intestinal tear.
  • If you have swelling or inflammation in your bowels, you should not take Prucalopride as such condition can result in Crohn’s disease, ulcerative colitis, and toxic megacolon or megarectum.
  • If you have severe kidney problems, your body may not be able to clear the drug effectively, thus leading to an increased risk of side effects. Talk to a medical professional before starting your treatment with Prucalopride. The expert may adjust your dosage accordingly.
  • Before using this drug, let your physician know about your allergies or if you are allergic to any of the product’s components. The medication may contain certain inactive ingredients that can cause severe allergic reactions. 
  • If you are undergoing surgery or any medical procedure, tell your healthcare provider about the products you use. This includes all prescription drugs, over-the-counter drugs, or any herbal product.
  • Prucalopride may make you dizzy. So, do not drive or operate heavy machines that demand complete attention. Also, avoid consuming any substance, including alcohol, that can make you dizzy.
  • Before starting the treatment with this medication, tell your medical provider about your medical history, especially of:
    • Kidney problems
    • Liver problems
    • Diabetes
    • Heart problems
    • Mental or mood changes and 
    • Stomach disorders

Storage 

  • Keep your medicines at room temperature in their original container.
  • Avoid exposure to light and moisture.
  • Do not flush the medication down the toilet.
  • Keep the medicines out of reach and sight of your children and pets.
  • Throw the product away once it reaches its expiration date or when not in use.
  • Do not keep your medication in damp areas like the bathroom or near the sink.
  • Ask your medical practitioner or pharmacist how to dispose of the medication appropriately without harming the environment.
  • Read the product’s label for detailed storage instructions.

Prucalopride Interactions

Drug interactions happen when two or more medications interact with each other. This interaction may occur in two ways. It either affects Prucalopride’s functioning or may increase its risk of side effects. Here are some of the drugs that may interact with Prucalopride:

  • Aclidinium
  • Atropine
  • Belladonna
  • Benztropine
  • Biperiden
  • Clidinium
  • Cyclizine
  • Darifenacin
  • Ethinyl estradiol
  • Flavoxate
  • Gilteritinib
  • Ipratropium
  • Meclizine
  • Procyclidine
  • Propantheline
  • Revefenacin
  • Solifenacin
  • Umeclidinium

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Prucalopride Alternatives

  • MiraLAX 
  • Lactulose (Generlac)
  • Lubiprostone (Amitiza)
  • Linaclotide (Linzess)
  • Plecanatide (Trulance)
  • Tegaserod (Zelnorm)
  • Lactitol

[Note: Your healthcare provider will choose which Prucalopride alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

Can women take Prucalopride (Motegrity)?

Yes, women can take Prucalopride. It can be used in adults, including men, women, and senior patients. However, it is important to always consult with a professional practitioner to ensure it is appropriate for individual health conditions and needs.

What are the serious side effects of Prucalopride?

Serious side effects of Prucalopride include severe abdominal pain, persistent diarrhea, allergic reactions (rash, itching, swelling), and suicidal thoughts and behavior. If any of these occur, seek medical attention promptly.

Can I use Prucalopride if I am pregnant?

Prucalopride should be used during pregnancy only if clearly needed and prescribed by a healthcare provider. Discuss the potential risks and benefits with your doctor to determine if it is safe for your specific situation.

Can I take Prucalopride with other constipation medications?

It is important to consult a medical provider before combining Prucalopride with other constipation medications. They can provide information on potential interactions and the most effective treatment plan based on your health needs.

Our Guarantee

At Arctic Meds, we guarantee that you will find the most competitive prices for purchasing Prucalopride through our platform. As the best Canadian online pharmacy, we are committed to delivering only the highest quality products. Each order is fulfilled through a reputable and licensed Canada pharmacy online, ensuring that every product we ship meets stringent standards of quality and authenticity. Our reliable service ships your medications directly from Canada right to your doorstep. For seamless access to buy Prucalopride online from Canada at a low price contact us.

SHIPPING

All orders are shipped via XPRESS POST arriving between 3-5 business days.
(Shipping times may vary based on time of year)

Shipping prices:
Refrigerated items $29.99
Non-refrigerated items $19.99

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