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Plendil is an FDA-approved medication used to treat hypertension and certain types of angina. As a calcium channel blocker, it relaxes blood vessels, reducing blood pressure and workload on the heart. Available in 2.5 mg, 5 mg, and 10 mg strengths, it’s typically taken once daily, with dosage adjustments as needed. Caution is advised for patients with hepatic impairment, and regular monitoring is essential for optimal management and safety.

Product Overview 

Plendil is an FDA-approved medication used primarily for the management of hypertension (high blood pressure) and certain types of angina (chest pain). It falls under the category of medicines called calcium channel blockers. These drugs impede the entry of calcium ions into heart and blood vessel muscle cells. This action leads to relaxation and dilation of blood vessels, reducing peripheral vascular resistance and blood pressure.

For oral administration, Plendil is available in 2.5 mg, 5 mg, and 10 mg strengths. The recommended initial dose for adults with hypertension is typically 5 mg once daily, with adjustments made based on individual response. Plendil is contraindicated in patients with hypersensitivity to felodipine or other dihydropyridines. Exercise caution when administering to patients with liver impairment and avoid those with severe liver impairment. Regular blood pressure monitoring and periodic medical reviews are essential to ensure optimal management and monitor for potential side effects. 

Plendil can potentially interact with various medications, underscoring the importance of patients disclosing all drugs, supplements, and herbal products to their healthcare providers. Proper storage of Plendil tablets is crucial to maintaining their efficacy, and any unused or expired medicines should be disposed of properly according to local regulations.

Uses of Plendil 

• High blood pressure 

Benefits of Plendil 

• Controls high blood pressure
• Improves blood flow to the heart
• Reduces the workload on the heart
• Helps prevent chest pain (angina)
• May prevent heart attacks

Side Effects of Plendil 

Common side effects of Plendil may include:

• Headache
• Dizziness
• Flushing
• Palpitations
• Fatigue
• Nausea
• Swelling of the ankles or feet (edema)
• Rash
• Abdominal pain
• Increased heart rate (tachycardia)
• Gingival hyperplasia (gum swelling)
• Frequent urination

[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]

Plendil Dosage

Forms & Strengths

Plendil tablet comes in the following strengths:

• 2.5 mg
• 5 mg
• 10 mg

Recommended Dosages

For Adults with Hypertension

• The starting dose is 5 mg once regularly.
• The dosage might be adjusted to 10 mg once daily, depending on how the patient reacts, after a period of 1-2 weeks.
• Depending on tolerability and effect, the dose may gradually increase for patients experiencing insufficient response with 5 mg.

For Elderly Patients

• Start with a lower initial dose, such as 2.5 mg once daily, particularly for those who may be more sensitive to the effects of felodipine.

For Patients with Hepatic Impairment

• Patients with liver impairment should start with a lower dose of 2.5 mg once daily because the liver metabolizes felodipine, and these patients may have a slower drug clearance.

How to Take Plendil? 

• Take the medication once daily, at the same time each day.
• Consume the extended-release tablet whole; avoid crushing, chewing, or splitting it.
• It can be taken with or without food, but avoid taking it with grapefruit or grapefruit juice.
• Maintain a consistent routine for taking the medication to ensure stable blood levels.
• Your blood pressure is checked regularly to monitor the effectiveness of the medication.

Missed Dose 

If you miss a dose of Plendil, take it as soon as you remember. However, if it’s close to your next scheduled dose, leave the missed dose of this medication and continue with your routine dosing schedule. Avoid taking double doses to compensate for a missed one.

[Note: Do not simultaneously take two doses of Plendil to compensate for a missed dose. This can elevate your risk of experiencing side effects.]

Overdose

An overdose of Plendil can lead to serious complications. If you suspect an overdose, seek immediate medical attention or contact a poison control center right away. Signs of an Plendil overdose may include severe dizziness, fainting, rapid or pounding heartbeat, shortness of breath, and confusion. 

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Plendil Work?

Plendil, a calcium channel blocker, hinders calcium ion movement into heart and blood vessel muscle cells. This prompts vessel relaxation, reducing vascular resistance and blood pressure. It reduces the heart’s workload, making it a useful option for managing hypertension and certain angina types.

Important Safety Precautions 

• Ensure regular monitoring to avoid shallow blood pressure.
• It can increase blood levels of felodipine, potentially leading to severe side effects.
• It might intensify the effects on lowering blood pressure and raise the possibility of side effects.
• To prevent dizziness and lightheadedness from sitting or lying, get up slowly.
• Felodipine can cause dizziness; hence, be cautious when driving or operating machinery.
• Inform your doctor about all medications you are taking, as felodipine can interact with other drugs.
• Notify your healthcare professional if you experience swelling of the hands, ankles, or feet.
• Consult with your doctor if you are pregnant or breastfeeding, as felodipine may not be safe during these periods.
• Get immediate medical help if you note signs of an allergic reaction, like rashes, swelling, itching, or trouble breathing.
• Regular check-ups are essential to adjust the dose and assess for any potential side effects.

Storage 

• Store Plendil tablets at room temperature between 20°C to 25°C.
• Keep the tablets away from moisture and light.
• Do not store Plendil in the bathroom or near a sink, as moisture can damage the tablets.
• Keep the container away from excessive heat and direct sunlight.
• Do not remove the desiccant (moisture-absorbing packet) from the bottle.
• Keep Plendil out of the reach of children and pets.
• Do not use Plendil tablets after the expiration date printed on the bottle.
• Discard any unused or expired Plendil tablets properly, according to local regulations.

Plendil Interactions 

• Cimetidine: Can increase the levels of felodipine in the body, potentially increasing side effects.
• Antifungal medications (e.g., ketoconazole, itraconazole): Can raise felodipine levels and risk of toxicity.
• Antiretroviral medications (e.g., ritonavir, saquinavir): Can significantly increase felodipine exposure.
• Clarithromycin: Can increase felodipine levels and its effects.
• Cyclosporine: Felodipine can increase cyclosporine levels, potentially causing toxicity.
• Carbamazepine, phenobarbital, phenytoin: These anti-seizure medications can decrease felodipine levels, reducing effectiveness.
• Rifampin: This can significantly decrease felodipine levels in the body.
• Beta-blockers: Felodipine can potentially increase the risk of bradycardia (slow heart rate) when combined with beta-blockers.
• Alpha-blockers: May increase the risk of hypotension (low blood pressure) when used with felodipine.
• Grapefruit juice: Can increase felodipine levels, potentially leading to adverse effects.

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Plendil Alternatives 

• Norvasc (amlodipine)
• Cardizem (diltiazem)
• Calan (verapamil)
• Sular (nisoldipine)
• Procardia (nifedipine)
• Covera-HS (verapamil)
• Isoptin SR (verapamil)

[Note: Your healthcare provider will choose which Plendil alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is it safe to cut Plendil tablets in half?

Cutting, splitting, chewing, or crushing Plendil tablets is not recommended. These tablets are designed as extended-release medications with a special coating that facilitates gradual release in the body. Altering the tablet may disrupt the coating and interfere with proper medication release. If swallowing difficulties arise, consult your provider for alternative options.

Is Plendil taken twice daily?

Plendil is usually taken once daily, with its effects lasting around 24 hours. Your healthcare provider could adjust your dosage depending on your reaction to the medication. Never alter your medication regimen without consulting your provider first.

Is it safe to consume alcohol while taking Plendil?

It’s advisable to refrain from drinking alcohol when on blood pressure medications like Plendil. Regular alcohol consumption can elevate blood pressure and potentially diminish the effectiveness of the medication. Additionally, it may exacerbate medication side effects such as dizziness. If eliminating alcohol poses challenges, consult your healthcare provider for guidance.

Can Plendil lead to dry mouth?

While uncommon, dry mouth has been reported as a potential side effect of Plendil. If you experience dry mouth while taking this medication, inform your healthcare provider. They may suggest strategies to alleviate symptoms, such as using saliva substitutes, chewing sugar-free gum, or staying hydrated with frequent small sips of water.

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