Pirfenidone
What is Pirfenidone?
Pirfenidone is an FDA-approved prescription medication used to treat idiopathic pulmonary fibrosis (IPF), a lung disease that leads to scarring and stiffening of the lungs, making it difficult to breathe. To help manage this condition, doctors prescribe Pirfenidone to slow the progression of IPF. This medication comes in both tablet and capsule forms and is intended for adult use only. As with any medication, Pirfenidone may cause side effects if not taken as directed by a healthcare provider. So, if you want to buy Pirfenidone online, you need to get a valid prescription from your doctor.
Product Overview
Pirfenidone is an FDA-approved medication used to treat IPF (idiopathic pulmonary fibrosis). The active ingredient, Pirfenidone, reduces lung fibrosis and inflammation and slows the disease’s progression. Available in tablet and capsule forms, typically in 267 mg and 801 mg strengths, it should be taken with food to reduce gastrointestinal side effects.
The drug inhibits the production of transforming growth factor-beta and tumor necrosis factor-alpha, which are involved in lung fibrosis. Common side effects include nausea, rash, fatigue, diarrhea, and loss of appetite. Patients should avoid direct sunlight and wear protective clothing due to the risk of photosensitivity.
Additionally, you can store Pirfenidone at room temperature, which is out of children’s reach. With proper medical supervision and adherence, Pirfenidone helps manage IPF, offering patients a way to slow the disease’s progression. When you buy Pirfenidone online to treat idiopathic pulmonary fibrosis, you will require a prescription from your doctor.
Uses of Pirfenidone
- This medication is used to treat idiopathic pulmonary fibrosis, a lung disease characterized by progressive scarring.
Benefits of Pirfenidone
- Slows Disease Progression
- Improves Survival Rates
- Reduces Exacerbations
- Anti-Inflammatory Effects
- Antifibrotic Activity
- Improves Quality of Life
- Easy Oral Administration
Side Effects of Pirfenidone
Common Pirfenidone side effects may include:
- Sore throat
- Weight loss
- Nausea
- Headache
- Joint pain
- Dizziness
- Upper respiratory tract infection
- Mild allergic reaction
- Insomnia
- Sneezing
- Abdominal pain
- Fatigue
- Skin rash
- Stuffy nose
- Diarrhea
- Gastroesophageal reflux disease
- Upset stomach
- Not feeling hungry
[Note: This list is not exhaustive, if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]
Pirfenidone Dosage
Forms & Strengths
It is available in the following forms and strengths:
- Capsule: 267 mg
- Tablet: 267 mg and 801 mg
Recommended Dosages
Dosage for Idiopathic Pulmonary Fibrosis
Generally, healthcare providers start with a low dose and gradually increase it as needed. It’s important to remember that the following dosage guidelines are general recommendations. So, if you want to buy Pirfenidone online from Canada, consider the following dosage recommendations:
For Adults:
- Days 1 to 7: 267 mg three times daily
- Days 8 to 14: 534 mg three times daily
- Day 15 and onward: 801 mg three times daily
For Children: Consult a healthcare provider before beginning treatment, as the safety and effectiveness of Pirfenidone in children have not yet been established.
How to Take Pirfenidone?
- Follow the dosage instructions for Pirfenidone exactly as prescribed by your doctor.
- Take Pirfenidone by mouth with food three times daily, as directed by your practitioner. Food helps reduce dizziness and nausea.
- Swallow the medication whole with a glass of water.
- Do not break, split, chew, or crush the tablets or capsules, as this can cause the drug to release too quickly.
- Regular blood tests are needed to monitor your liver function during treatment, as your dosage may depend on these results.
- Do not take more than three doses of Pirfenidone per day to avoid side effects.
- Do not abruptly stop taking Pirfenidone without consulting your doctor, as this may cause adverse reactions.
Missed Dose
Doctors generally advise not missing a dose of Pirfenidone, but if you do, take it as soon as you remember. If your next dose is soon, skip the missed dose and resume your regular schedule without doubling up, as this may increase side effects. Consider using medication apps or a pill box to help avoid missed doses. If you’ve missed doses for 14 consecutive days, restart the treatment. Consult a healthcare professional if you’re unsure about what to do.
[Note: Do not take two doses of Pirfenidone at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]
Overdose
It’s essential to follow your doctor’s guidance and avoid taking extra doses of Pirfenidone, as overdosing can lead to serious adverse reactions. If you’ve accidentally taken too much and are experiencing unusual symptoms like fainting or difficulty breathing, immediate action is crucial. Visit the nearest clinic or call 911 for urgent medical assistance to ensure your safety and well-being. Remember, timely intervention can make a significant difference in such situations.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Pirfenidone Work?
This medication helps reduce inflammation and slow the progression of lung fibrosis by inhibiting the production of fibroblast growth factors and transforming growth factor-beta (TGF-β), key contributors to scarring. By targeting these pathways, Pirfenidone helps maintain lung function and enhances the quality of life for IPF patients.
Important Safety Precautions
- Before starting this medication, inform your doctor about any allergies, especially to Pirfenidone or its ingredients.
- This medication may contain inactive ingredients that could cause allergic reactions.
- If you’re having surgery or a medical procedure, let your healthcare provider know about all the products you use, including prescription drugs, over-the-counter medicines, and herbal supplements.
- Share your medical history with your doctor, especially if you have kidney or liver problems.
- Pirfenidone can make your skin more sensitive to the sun.
- If you get sunburned or develop redness or blisters, contact your doctor right away.
- Avoid driving or operating heavy machinery right after taking the medication.
- Alcohol can increase the side effects of this medication, like dizziness. Limit alcohol and marijuana use during treatment.
- If you’re pregnant or planning to become pregnant, consult your doctor before using Pirfenidone, as it may harm the baby.
- If you’re breastfeeding, talk to your doctor to find out if it’s safe to continue while on this medication.
- Avoid smoking while taking this medication, as it may cause adverse reactions.
Storage
- Store Pirfenidone tablets and capsules at room temperature, ideally at 25°C (77°F).
- Keep the medication in its original, tightly closed container.
- Use safety locks on the container to prevent accidental poisoning of children or pets.
- Avoid storing the tablets in damp or moist areas, such as bathrooms or near sinks.
- Keep the medication out of direct sunlight and away from heat sources.
- Store your medication in a safe location that is out of the reach and sight of children and pets.
- Do not use Pirfenidone if the expiration date has passed. The expiration date is the last day of the month shown on the prescription label or carton.
- The best method for disposing of unwanted medication is through a medicine take-back program.
Pirfenidone Interactions
- Levoketoconazole
- Viloxazine
- Amiodarone
- Lomitapide
- Pexidartinib
- Enoxacin
- Mipomersen
- Ciprofloxacin
- Fluvoxamine
- Givosiran
- Ritlecitinib
- Osilodrostat
- Teriflunomide
- Vemurafenib
- Leflunomide
- Ketoconazole
- Mibefradil
- Aminolevulinic acid
- Capmatinib
- Rucaparib
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
Pirfenidone Alternatives
- Actimmune
- Ofev (nintedanib)
- Interferon gamma-1b
- Nintedanib
[Note: Your healthcare provider will choose which Pirfenidone alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
Can Pirfenidone Cure Fibrosis?
Well, it has been proven effective in slowing the progression of scarring in the lungs, a condition known as pulmonary fibrosis. The medication works by reducing the activity of the immune system, thereby decreasing the inflammatory response that contributes to the formation of scar tissue. Pirfenidone is typically prescribed to be taken in capsule form three times a day as part of a long-term treatment plan aimed at managing the symptoms and progression of the disease.
Is Pirfenidone Safe?
Pirfenidone, a medication prescribed for the treatment of idiopathic pulmonary fibrosis, is generally considered safe when used under the guidance of a healthcare provider. However, it is important to be aware that it may cause a range of side effects. The most commonly reported side effects associated with pirfenidone include nausea and vomiting. So, when you buy Pirfenidone online to treat idiopathic pulmonary fibrosis, consider this medication safe to use.
Is Pulmonary Fibrosis an Immune Disease?
Yes. Pulmonary fibrosis can be caused by autoimmune conditions, which are diseases where the immune system attacks the body. It can also result from chronic hypersensitivity pneumonitis due to exposure to environmental factors like molds in the home or workplace. Buy Pirfenidone online for effective treatment.
What Are the Warnings for Pirfenidone?
Pirfenidone may rarely cause serious liver damage. It is important to seek immediate medical attention if you experience any symptoms indicative of liver issues, such as persistent nausea or vomiting, loss of appetite, yellowing of the eyes or skin, stomach or abdominal pain, or dark-colored urine. Additionally, while a severe allergic reaction to pirfenidone is uncommon, it can occur and requires urgent medical care if it does.
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