Tranylcypromine
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Parnate (tranylcypromine) is a prescription medication that is approved by the FDA to treat major depressive disorder, especially in patients who haven’t responded to other antidepressants. It works by inhibiting the enzyme monoamine oxidase (MAO), which helps increase neurotransmitters like serotonin, norepinephrine, and dopamine in the brain. This improvement in neurotransmitter balance can relieve depressive symptoms and improve mood. Parnate is typically prescribed when other treatments have failed and is known for its faster-acting effects. However, it requires careful monitoring due to dietary restrictions and potential side effects.
Product Overview
Parnate is an MAOI (monoamine oxidase inhibitor) that contains the active ingredient tranylcypromine. It is prescribed to treat major depressive disorder, especially when other treatments have not been effective. It works by inhibiting the enzyme monoamine oxidase (MAO), which breaks down key neurotransmitters such as serotonin, dopamine, and norepinephrine. By increasing the levels of these neurotransmitters, Parnate helps regulate mood and alleviate depressive symptoms, particularly in cases of treatment-resistant depression.
Parnate is known for its relatively fast action compared to other antidepressants, offering relief to individuals struggling with both typical and atypical depression. While it can be highly effective, Parnate requires careful monitoring due to its potential interactions with certain foods and other medications.
Patients must avoid tyramine-rich foods like aged cheeses and cured meats to prevent dangerous increases in blood pressure. Regular follow-ups with healthcare providers are essential to manage dosage adjustments and monitor for side effects. Parnate may also help with conditions like social anxiety, panic disorder, and even Parkinson’s disease-related depression.
What Are the Uses of Parnate?
Parnate is used for the treatment of:
- Depressive psychosis
- Depression
- Arteriosclerotic dementia with depressive features
- Dementia with depressive features
What Are the Benefits of Parnate?
- It effectively treats major depressive disorder, especially in cases resistant to other antidepressants.
- It is particularly useful for atypical depression and treatment-resistant depression.
- It can provide relief for patients with social anxiety disorder or panic disorder.
- It may help improve energy levels and reduce feelings of fatigue in depressed patients.
- It can be effective in treating Parkinson’s disease-related depression.
- It often works more quickly than some other types of antidepressants.
- It may help improve sleep patterns in some patients with depression.
- It can be beneficial for patients with anergic bipolar depression.
- It is potentially helpful in treating attention deficit hyperactivity disorder (ADHD) in adults.
- It may help reduce cravings and withdrawal symptoms in substance abuse disorders.
- It can be effective in treating bulimia nervosa and binge eating disorders.
- It offers an alternative treatment option for patients who haven’t responded to other antidepressants.
What Are the Side Effects of Parnate?
Common Parnate side effects may include:
- Chills
- Numbness or tingly feeling
- Frequent headaches
- Weakness
- Dry mouth
- Constipation
- Blurred vision
- Vision changes
- Stomach pain
- Impotence
- Not feeling hungry
- Difficulty while sleeping
- Less urination
- Drowsiness
- Restlessness
- Difficulty having an orgasm
- Ringing in your ears
- Diarrhea
- Nausea
[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]
Parnate Dosage
What Are the Forms & Strengths of Parnate?
It comes in the form of an oral tablet and has a strength of:
- Parnate 10 mg tablet
What Are the Recommended Dosages of Parnate?
General Dosage Recommendations
- Initial Dose: Typically, doctors start with a daily dose of 30 mg of Parnate, divided throughout the day.
- Adjustments: If the initial dose isn’t practical, your doctor may increase the dose by 10 mg at intervals of 1 to 3 weeks.
- Maximum Dose: 60 mg. divided into two doses of 30 mg each.
How to Take Parnate?
- Take Parnate by mouth with or without food, as directed by your doctor.
- Swallow the tablets whole with a glass of water. Do not break, chew, or crush them, as this can release the drug too quickly.
- If you cannot swallow the tablets, consult your healthcare provider for alternative options.
- Do not change your dose without your doctor’s advice, as this can cause serious side effects.
- Stop using Parnate if you are scheduled for surgery or a medical procedure, but consult your doctor first.
- Finish your entire course of treatment, even if you feel better.
- Do not stop taking Parnate suddenly, as this can cause withdrawal symptoms like confusion, restlessness, headache, hallucinations, diarrhea, and weakness.
- Take Parnate at the same time each day for the best results.
What To Do When You Miss A Dose?
If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one and continue your regular schedule.
[Note: Do not take two doses of Parnate simultaneously to compensate for a missed dose. This can increase your risk of experiencing side effects.]
What Happened When You Overdose on Parnate?
Avoid taking extra doses of Parnate. If you overdose and experience unusual symptoms, stop using Parnate and seek medical assistance or call 911.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Parnate Work?
Parnate contains tranylcypromine, which works by blocking the enzyme monoamine oxidase (MAO). MAO breaks down neurotransmitters like serotonin, norepinephrine, and dopamine, which are chemicals in the brain that affect mood. By inhibiting this enzyme, Parnate increases the levels of these neurotransmitters, improving mood and relieving depressive symptoms.
Important Safety Precautions
- Inform your doctor about any allergies to Parnate or its ingredients, as inactive components can cause adverse reactions.
- Discuss your medical and family history, particularly mental disorders, thyroid issues, seizures, heart conditions, frequent headaches, pheochromocytoma, glaucoma, high blood pressure, kidney, liver, or cerebrovascular diseases.
- Avoid Parnate if you have heart issues, and refrain from intense exercise.
- Alcohol and marijuana may worsen these effects; avoid driving or operating heavy machinery.
- Parnate is not recommended for older adults due to a heightened risk of side effects, especially blood pressure issues.
- Use only if necessary, as Parnate can harm a fetus and pass into breast milk. Discuss risks and benefits with your doctor.
- Do not stop Parnate abruptly; taper off under medical supervision to avoid withdrawal symptoms.
- MAO inhibition effects can persist for up to 10 days. Be cautious with foods high in tyramine and interactions with certain drugs.
- Watch for increased anxiety and agitation in patients and adjust treatment as necessary.
How to Store Parnate?
- Store Parnate at room temperature between 15°C to 30°C (59°F to 86°F).
- Always store Parnate in a safe place out of sight and within reach of children and pets.
- Do not flush Parnate down the toilet.
What May Interact with Parnate?
- Seizures
- Angina
- Bipolar disorder screening
- Pheochromocytoma
- Liver disease
- Hypoglycemia
- Diabetes
- Schizophrenia/Bipolar
- Hyperthyroidism
- Alcohol
- Hypotension
- Renal disease
- Tyramine-rich food
- Hypertension/CVD
- Parkinsonism
[Note: This list of interactions is not complete. Talk to your doctor if you experience any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
What Are the Parnate Alternatives?
- Lexapro
- Citalopram
- Cymbalta
- Wellbutrin XL
- Fluoxetine
- Zoloft
- Bupropion
- Sertraline
[Note: Your healthcare provider will choose which Parnate alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Parnate Cost & Coupons
The cost of Parnate can vary significantly depending on health insurance coverage. Many Americans find their insurance does not cover Parnate. To help manage these costs, you can choose to buy Parnate online from Canada, where it may be available at a more affordable price. Additionally, using a Parnate coupon code can reduce costs. Arctic Meds offer the opportunity to buy Parnate from Canada in the USA, providing a cost-effective solution for those needing this medication.
Frequently Asked Questions
Will I gain weight during my treatment with Parnate?
Weight gain is not typically associated with Parnate, but individual responses to medication can vary. If you notice significant weight changes, discuss this with your healthcare provider. They will evaluate the cause and suggest ways to address any weight-related issues, possibly adjusting your treatment plan as needed.
Does Parnate come under the controlled substance?
No, Parnate is not classified as a controlled substance. However, it is a prescription medication and should be used only under the supervision of a healthcare provider. Always follow your physician’s instructions and use Parnate strictly as directed to ensure its safety and effectiveness in treating major depressive disorder.
What happens if I stop taking Parnate?
Abruptly stopping Parnate can lead to withdrawal symptoms and a resurgence of depressive symptoms. It’s crucial to follow your healthcare provider’s recommendations when discontinuing the medication. They will likely advise a gradual reduction in dosage to minimize withdrawal effects and ensure a safe cessation process, thus reducing the risk of adverse effects.
Does Parnate affect my sleep?
Yes, Parnate may affect your sleep cycle, potentially causing insomnia or difficulty sleeping. If you experience significant changes in your sleep patterns or have trouble sleeping, it’s essential to notify your doctor. They may adjust your dosage or offer strategies to manage this side effect, ensuring your treatment continues to be effective.
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