Elagolix

Buy Orilissa Online

Orilissa offers relief from moderate to severe endometriosis pain by reducing estrogen levels and starting pain reduction within days. It’s a non-invasive option that can lessen or eliminate menstrual bleeding and has minimal impact on bone density compared to other treatments. Available in 150 mg & 200 mg tablets, it requires careful dosage adherence and includes potential side effects like hot flashes and nausea. Effective contraception is essential during and after treatment to avoid pregnancy risks. Consult your healthcare professional for tailored guidance on managing endometriosis with Orilissa.

Product Overview

Orilissa (elagolix) is a breakthrough medication designed to alleviate the debilitating pain associated with moderate to severe endometriosis. It works by reducing the production of estrogen, a hormone that exacerbates endometriosis symptoms. By acting as a GnRH antagonist, Orilissa effectively suppresses estrogen levels from the ovaries, thereby alleviating pelvic pain, menstrual cramps, and other associated discomforts. This medication offers relief that can begin within days of starting treatment, providing a non-invasive alternative to surgical procedures commonly used to manage endometriosis.

Orilissa not only reduces pain but also has the potential to diminish or eliminate menstrual bleeding in some patients. Unlike some treatments, it minimizes impact on bone density when used as recommended. Importantly, the hormonal effects of Orilissa are reversible upon discontinuation, allowing flexibility in managing symptoms over time.

However, like all medications, Orilissa may cause side effects, including hot flashes, headache, nausea, insomnia, mood changes, joint pain, and decreased bone mineral density. It interacts with certain medications and requires careful adherence to dosage and timing instructions provided by healthcare providers. Orilissa is available in tablet form with strengths tailored to the severity of symptoms, ensuring personalized treatment plans for each patient’s needs.

Uses of Orilissa 

• Pain from endometriosis that ranges from moderate to severe

Benefits of Orilissa 

• Reduces endometriosis-associated pain
• Pain reduction can begin within days of starting treatment
• Provides an alternative to invasive procedures
• Suppresses estrogen production, helping to manage endometriosis
• Can reduce or eliminate menstrual bleeding in some women
• Less impact on bone density compared to some other treatments (at recommended durations)
• Hormonal effects are generally reversible upon discontinuation

Side Effects of Orilissa 

Common Orilissa side effects may include:

• Hot flashes or night sweats
• Headache
• Nausea
• Difficulty sleeping (insomnia)
• Mood changes like anxiety, depression
• Joint pain
• Decreased bone mineral density
• Menstrual changes:
• Increased liver enzymes
• Fatigue
• Dizziness
• Constipation or diarrhea
• Weight gain
• Decreased libido (sex drive)
• Skin reactions

[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]

Orilissa Dosage

Forms & Strengths

Orilissa is available in tablet form and has the following strengths:

• 150 mg tablets
• 200 mg tablets

Recommended Dosages

For management of moderate endometriosis pain:

• 150 mg once daily for up to 24 months

For management of severe endometriosis pain:

• 200 mg twice a day for up to 6 months.

Patients with moderate hepatic impairment:

• 150 mg once a day for up to 6 months.

Patients with mild hepatic impairment:

• No dosage adjustment is required.

Patients with renal impairment:

• No dosage adjustment is required.

Patients taking potent OATP1B1 inhibitors:

• 150 mg once daily for atleast 6 months.

Adolescents (post-menarchal):

• Safety and efficacy were not established and were not recommended.

Elderly patients (65 years and older):

• Limited data are available. Use with caution

How to Take Orilissa?  

• Orilissa is typically taken by mouth once daily, with or without food.
• Swallow the Orilissa tablet whole with a glass of water.
• Take Orilissa at the same time each day to maintain consistent levels in your body.
• If you miss a dose, take it as soon as you remember unless it’s close to your next dose. Do not double up on doses.
• Follow your healthcare provider’s instructions carefully to manage your condition best.

Missed Dose 

If you miss a dose of Orilissa (elagolix), take it as soon as you remember unless it’s close to your next scheduled dose. If this happens, skip the missed dose of Orilissa and continue your regular dosing schedule. Do not take a double dose to make up for the missed one. Maintaining consistent dosing is essential to ensure the medication’s effectiveness in managing your condition. 

[Note: Do not simultaneously take two doses of Orilissa to compensate for a missed dose. This can increase your chances of experiencing side effects.]

Overdose

In case of an overdose of Orilissa (elagolix), it’s essential to seek immediate medical assistance or contact a poison control center right away. Overdose symptoms may include nausea, vomiting, and abdominal pain. It’s crucial to follow the prescribed dosage strictly and not exceed the prescribed amount of this medication to avoid potential complications.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Orilissa Work?

Orilissa functions by inhibiting the production of estrogen, a hormone that can exacerbate conditions like endometriosis. As a GnRH antagonist, it reduces the amount of estrogen released by the ovaries, thereby alleviating symptoms such as pelvic pain and menstrual cramps associated with endometriosis. This targeted hormone reduction helps manage the pain and other symptoms without completely shutting down estrogen production, allowing for a balance in hormone levels that can mitigate side effects.

Important Safety Precautions

• Take Orilissa precisely as prescribed by your healthcare provider.
• Inform your medical expert about all medications and supplements you are currently taking.
• Follow instructions carefully regarding the timing and administration of meals and other medications.
• Use effective non-hormonal contraception while taking Orilissa and for at least 28 days after stopping treatment.
• Attend all scheduled medical appointments & laboratory tests as your healthcare provider recommends.
• Report any new or unusual symptoms to your doctor promptly.
• Store Orilissa at room temperature and away from moisture and sunlight.
• Keep Orilissa out of reach of children and pets.

Storage 

• Store Orilissa at room temperature between 68°F to 77°F.
• Keep the medication in its original blister package until ready to use.
• Store away from moisture and direct sunlight.
• Keep Orilissa out of reach of children and pets.
• Do not use Orilissa after the expiration date printed on the package.
• Dispose of any unused or expired tablet according to local regulations.

Orilissa Interactions 

• Estrogen-Containing Products: Combined use with estrogen-containing products may reduce the effectiveness of Orilissa.
• CYP3A4 Inducers: Drugs that induce CYP3A4 enzymes (e.g., rifampin, carbamazepine) may decrease Orilissa levels.
• CYP3A4 Inhibitors: CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase Orilissa levels.
• Proton Pump Inhibitors (PPIs): PPIs may decrease Orilissa absorption.
• Opioids: Orilissa may increase the levels of opioids, requiring dose adjustments.

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Orilissa Alternatives 

• Lupron Depot (leuprolide acetate)
• Zoladex (goserelin)
• Synarel (nafarelin)
• Depo-Provera (medroxyprogesterone acetate)
• Ibuprofen (ibuprofen)
• Naproxen (naproxen)
• Femara (letrozole)
• Arimidex (anastrozole)
• Myfembree (relugolix, estradiol, and norethindrone acetate)
• Cymbalta (duloxetine)
• Effexor (venlafaxine)
• Neurontin (gabapentin)
• Lyrica (pregabalin)

[Note: Your healthcare provider will choose which Orilissa alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

How quickly does Orilissa begin to take effect?

Orilissa typically lowers hormone levels within 6 hours of ingestion, but relief from endometriosis symptoms may take several months. Consistent adherence to prescribed dosages is crucial for optimal results. Consult your healthcare specialist if you have any concerns about your treatment progress.

Can I still have children if I decide to stop taking Orilissa?

Orilissa does not permanently affect your fertility, but it poses risks during pregnancy that can harm an unborn baby. Before starting this medication, your healthcare provider ensures you are not pregnant. After stopping Orilissa, estrogen levels typically return to normal within one to two days. However, you should use non-hormonal birth control for 28 days post-treatment cessation to prevent pregnancy until your menstrual cycle resumes its regular pattern.

When should I start taking Orilissa?

Your healthcare provider will instruct you to begin Orilissa within 7 days after the onset of your menstrual period. Starting outside of this timeframe requires a pregnancy test to ensure you are not pregnant before initiating treatment with this medication.

Is Orilissa safe to use during pregnancy?

No, Orilissa is not safe to use during pregnancy due to potential risks of harm to the unborn baby, as observed in animal studies. It increases the risk of miscarriage or other complications. There is a pregnancy registry to monitor the safety of Orilissa for pregnant women. If you are pregnant or planning to become pregnant, consult your healthcare provider for alternative treatment options.

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