Edoxaban

Buy Lixiana Online

Lixiana, also known as edoxaban, is an anticoagulant used in adults to prevent stroke and systemic embolism in non-valvular atrial fibrillation and to treat or prevent deep vein thrombosis (DVT) and pulmonary embolism (PE). It offers the convenience of once-daily dosing without the need for routine blood monitoring. Lixiana works by inhibiting factor Xa, reducing the body’s ability to form clots. Common side effects include bleeding, anemia, and nausea. It’s important to follow your healthcare provider’s instructions and discuss any potential interactions or precautions, especially if you have pre-existing conditions or are taking other medications.

Product Overview

Lixiana (edoxaban) is an anticoagulant medication used to prevent stroke and systemic embolism in adults with non-valvular atrial fibrillation and to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE). As a direct factor Xa inhibitor, Lixiana works by blocking a critical enzyme in the blood clotting process, thereby reducing the body’s ability to form dangerous clots. This makes it an effective treatment for patients at risk of blood clot-related conditions.

One of Lixiana’s key advantages is its once-daily dosing, which enhances convenience and adherence compared to other anticoagulants like warfarin, which require routine blood monitoring. Additionally, Lixiana has a rapid onset of action, reaching peak effect within 1-2 hours, and does not have significant food interactions, allowing flexibility in dosing around meals. Studies have also shown that Lixiana has a lower risk of major bleeding, including intracranial hemorrhage, compared to well-managed warfarin.

Common side effects of Lixiana include bleeding, anemia, nausea, and rash. It is important to discuss your complete medical history with your healthcare provider before starting Lixiana, especially if you have conditions such as liver disease, a recent stroke, or a tendency to bleed easily. Lixiana may interact with other medications, including blood thinners, certain antibiotics, and herbal supplements. Proper storage and disposal of Lixiana are crucial to ensure safety, especially in households with children or pets. Always follow your healthcare provider’s guidance on dosage and precautions.

Uses of Lixiana

Lixiana is used in adults to:

• Pulmonary embolism & deep vein thrombosis
• Prevent stroke & systemic embolism

Benefits of Lixiana

• Effectively prevents stroke and systemic embolism in patients with non-valvular atrial fibrillation.
• Treats and prevents deep vein thrombosis (DVT) and pulmonary embolism (PE).
• Reduces the risk of recurrent venous thromboembolism (VTE).
• Requires no routine blood monitoring, unlike warfarin.
• Once-daily dosing improves convenience and potentially enhances medication adherence.
• Demonstrates a lower risk of major bleeding compared to well-managed warfarin in some studies.
• Rapid onset of action, typically reaching peak effect within 1-2 hours.
• No significant food interactions, allowing flexibility in dosing around meals.
• Fixed dosing for most patients, simplifying treatment regimens.
• May be associated with reduced risk of intracranial hemorrhage compared to warfarin.
• Can be used in a wide range of patient populations, including the elderly.
• Offers an alternative for patients who cannot tolerate or have difficulty managing warfarin therapy.

Side Effects of Lixiana

Common Lixiana side effects may include:

• Anemia
• Bleeding (various types)
• Rash
• Nausea

[Note: This list is not exhaustive, if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]

Lixiana Dosage

Forms & Strengths

It comes in tablets form and has these following strengths:

• Lixiana 15 mg tablet
• Lixiana 30 mg tablet
• Lixiana 60 mg tablet

Recommended Dosages

For Atrial Fibrillation

• Take 60 mg by mouth once daily.

For Deep Vein Thrombosis

• Take 60 mg by mouth once daily after completing 5 to 10 days of initial treatment with an injectable anticoagulant.

For Pulmonary Embolism

• Take 60 mg by mouth once daily after completing 5 to 10 days of initial treatment with an injectable anticoagulant.

How to Take Lixiana?

• Before taking Lixiana, read the directions for your prescription carefully. If you have any questions or if anything is unclear, consult your doctor or pharmacist.
• Follow your doctor’s instructions precisely when taking Lixiana. Do not alter the amount or duration of your dosage without guidance.
• Lixiana is available in tablet form and requires a prescription.
• The typical dose for preventing stroke in patients with atrial fibrillation is 60 mg, taken orally once a day.
• Swallow the tablet whole with a full glass of water. Do not break, crush, or chew it.
• If you find it hard to swallow the tablet whole, talk to your doctor about alternative methods. You might be able to crush the tablet and mix it with water or apple juice just before taking it, or your doctor might administer it through a nasal or stomach tube.
• Lixiana can be taken with or without food. Try to take it at the same time each day for consistency.
• Do not stop taking Lixiana suddenly without medical advice, as abruptly stopping can increase the risk of blood clots.

Missed Dose 

• If you miss a dose of Lixiana, take it as soon as you remember, then continue with your regular schedule.
• If it’s nearly time for your next dose, skip the missed dose and proceed with your usual dosing routine.
• Do not take a double dose to make up for the one you missed, as this could lead to adverse effects.
• Consider setting a reminder on your phone to help prevent future missed doses.

[Note: Do not take two doses of Lixiana simultaneously to compensate for a missed dose. This can increase your risk of experiencing side effects.]

Overdose

An overdose of Lixiana can cause severe bleeding. If you think you’ve taken too much, contact your doctor, call 911, or reach out to the poison control center immediately. You may also go to the nearest emergency room for prompt treatment.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Lixiana Work?

Lixiana, also known as edoxaban, is an anticoagulant medication that falls under the category of direct factor Xa inhibitors. It explicitly targets and blocks factor Xa, an essential enzyme in the blood clotting process. Lixiana effectively reduces the body’s ability to form blood clots by inhibiting this enzyme. This action disrupts both the intrinsic and extrinsic pathways of blood coagulation, leading to decreased production of thrombin and, ultimately, less fibrin, which is the protein that forms the structure of blood clots. 

Important Safety Precautions

• Lixiana may be less effective in preventing strokes for atrial fibrillation patients with excellent kidney function (CrCl > 95 mL/min).
• Do not stop Lixiana without consulting your doctor, as it increases the risk of blood clots and strokes. Your doctor will guide you on stopping before surgery and when to restart.
• Lixiana can cause severe spinal blood clots, especially if you have an epidural, have spine issues, or take NSAIDs/blood thinners. Monitor for symptoms like leg tingling or weakness.
• Inform your doctor of any medical history, especially stomach ulcers, liver disease, pregnancy, or severe bleeding. Avoid other medications without doctor approval.
• Do not use it if you have hypersensitivity, severe bleeding, or liver disease affecting clotting or if you are pregnant or breastfeeding.

Storage 

• Keep Lixiana tablets in their original packaging, securely closed to protect them from excess heat, sunlight, and moisture.
• Store all medications, including Lixiana, out of sight and within the reach of children and pets to ensure safety.

Lixiana Interactions

Some drugs can interact with Lixiana & interfere with how it may work.

• Warfarin
• Ibuprofen
• Dronedarone
• Phenobarbital
• Clarithromycin
• Erythromycin
• Ciclosporin
• Quinidine
• Aspirin
• Phenytoin
• Verapamil
• Fluconazole
• Rifampicin
• Carbamazepine
• Enoxaparin

Here are other interactions of Lixiana that may include:

• Coenzyme Q10
• St John’s wort
• Alcohol
• Grapefruit 

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Lixiana Alternatives

• Pradaxa (dabigatran)
• Xarelto (rivaroxaban)
• Eliquis (apixaban)
• Carvedilol (carvedilol)
• Digoxin (digoxin)

[Note: Your healthcare provider will choose which Lixiana alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

How should Lixiana be discontinued?

Do not stop taking Lixiana suddenly. Your doctor will advise you on how to reduce the dose gradually or provide an alternative to prevent the risk of blood clots. Always follow your doctor’s instructions.

Can Lixiana be used in patients with renal impairment?

If you have kidney problems, your doctor may need to adjust your Lixiana dosage since the drug is mainly removed from your body by the kidneys. Discuss your kidney condition with your healthcare provider to ensure proper dosing and monitoring.

What is the impact of liver disease on Lixiana use?

Avoid using Lixiana if you have severe liver disease, as it can increase your risk of bleeding and affect how the drug is processed in your body. Those with moderate liver issues should be closely monitored, and dosage adjustments may be needed. Consult with your healthcare provider for tailored advice.

How does Lixiana interact with other medications?

Lixiana can interact with other blood thinners, some heart medications, and specific antifungal treatments, possibly changing its effectiveness and increasing bleeding risks. Ensure you inform your healthcare provider about all the medicines you take to manage these interactions safely.

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