Inclisiran

Leqvio

Leqvio is an innovative biannual injection that lowers LDL cholesterol and reduces cardiovascular risks. By inhibiting PCSK9, it complements statin therapy for long-term cholesterol management. Common side effects include injection site reactions and fatigue. For affordable options, buy Leqvio online from Canada and consult your healthcare provider to ensure safe and effective use.

Product Overview 

Leqvio (inclisiran) is a groundbreaking medication designed to lower LDL cholesterol (bad cholesterol) and reduce cardiovascular risk in adults. It works by inhibiting PCSK9, enhancing the liver’s ability to clear LDL cholesterol effectively. Administered as a convenient biannual subcutaneous injection, Leqvio complements statin therapy to achieve long-term cholesterol management, making it a valuable option for individuals with hyperlipidemia or atherosclerotic cardiovascular disease (ASCVD).

Leqvio offers significant benefits, including over 50% reduction in LDL cholesterol levels, reduced risk of heart attack and stroke, and improved cardiovascular health in high-risk patients. Common side effects include injection site reactions, fatigue, muscle pain, and upper respiratory tract infections.

For those seeking cost-effective options, you can buy Leqvio online from Canada through trusted sources to manage expenses while accessing high-quality medication. Ensure proper storage, follow your provider’s dosage instructions, and consult your healthcare professional for personalized guidance on integrating Leqvio into your treatment plan.

What Are the Uses of Leqvio?

• Lowering LDL cholesterol (bad cholesterol)
• Reducing cardiovascular risk
• Managing hyperlipidemia
• Treating atherosclerotic cardiovascular disease (ASCVD)
• Supporting long-term cholesterol control

What Are the Benefits of Leqvio?

• Significantly lowers LDL (bad) cholesterol levels
• Helps reduce the risk of heart attack and stroke
• Provides long-lasting cholesterol management with biannual dosing
• Complements existing statin therapy for better heart health
• Improves cardiovascular health in high-risk patients
• Supports treatment for individuals with genetic cholesterol disorders

What Are the Side Effects of Leqvio?

Common Leqvio side effects may include:

• Injection site reactions (pain, redness, or swelling)
• Fatigue or tiredness
• Muscle pain or discomfort
• Joint pain (arthralgia)
• Headache
• Diarrhea
• Nausea
• Upper respiratory tract infections
• Back pain
• Dizziness
• Fever
• Swelling in the arms or legs (edema)
• Cough
• Sore throat
• Runny or stuffy nose (nasopharyngitis)
• Increased liver enzymes (detected in blood tests)
• Flu-like symptoms
• Rash or itching (pruritus)
• Allergic reactions (hives or swelling)

[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]

What Are the Forms & Strengths of Leqvio?

• Form: Solution for subcutaneous injection
• Strength: 284 mg/1.5 mL pre-filled syringe

What is the Typical Dosage of Leqvio?

Adults (18 Years and Older)

• Initial Dose: 284 mg administered as a single subcutaneous injection.
• Follow-Up Dose: A second injection of 284 mg is given 3 months after the initial dose.
• Maintenance Dose: Subsequent doses of 284 mg are administered every 6 months thereafter.

Pediatric Patients

• Usage Not Established: Leqvio is not currently approved for use in patients under 18.

Patients with Renal or Hepatic Impairment

• Standard Adult Dosage: No specific adjustments are recommended, but caution is advised, especially for patients with severe impairment. Consult your healthcare provider for individualized recommendations.

Elderly Patients

• Standard Adult Dosage: Generally well-tolerated in older adults, but close monitoring is recommended to assess response and potential side effects.

How to Take Leqvio?

• Administered as a subcutaneous injection by a healthcare professional.
• One injection of 284 mg.
• Administered 3 months after the initial dose.
• Subsequent injections every 6 months.
• Injection sites include the abdomen, upper arm, or thigh.
• Follow your healthcare provider’s schedule for all doses.
• Ensure missed doses are rescheduled promptly, as your doctor has advised.

What to Do When You Miss a Dose of Leqvio? 

If you miss a dose of Leqvio, contact your healthcare provider as soon as possible to reschedule. Do not double up on doses to compensate. Your provider will adjust your schedule to ensure optimal treatment effectiveness.

[Note: Do not simultaneously take two doses of Leqvio to compensate for a missed dose. This can increase your risk of experiencing side effects.]

What Happens When You Overdose on Leqvio?

An overdose of Leqvio is unlikely due to its administration by healthcare professionals. However, excessive dosing could theoretically increase the risk of side effects like liver enzyme elevation or injection site reactions. Seek immediate medical attention if an overdose is suspected.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Leqvio Work?

Leqvio works by targeting PCSK9, a protein that hinders the liver’s ability to remove LDL cholesterol (“bad” cholesterol) from the blood. It uses RNA interference technology to suppress PCSK9 production, allowing the liver to increase LDL receptor activity. This enhances cholesterol clearance, significantly reducing LDL levels. Administered biannually, Leqvio offers long-term cholesterol management, especially when combined with statins and lifestyle modifications for improved cardiovascular health.

What Are the Important Safety Precautions of Leqvio?

• Watch for symptoms like swelling, rash, or difficulty breathing. Seek immediate medical attention if they occur.
• Report any severe pain, redness, or swelling to your healthcare provider.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Leqvio’s safety in these conditions is not well-established.
• Regular liver function tests may be required, especially if combined with other cholesterol-lowering medications.
• Use with caution if you have severe kidney issues; consult your healthcare provider.
• Discuss all medications, supplements, and over-the-counter drugs you are taking to avoid interactions.
• Continue following a heart-healthy diet and exercise plan alongside treatment for optimal results.

How Do You Store Leqvio? 

• Store in the refrigerator at 36°F to 46°F (2°C to 8°C).
• Keep the injection in its original packaging to protect it from light.
• Do not freeze.
• If necessary, Leqvio can be stored at room temperature (up to 77°F or 25°C) for a maximum of 30 days.
• Keep out of reach of children and pets.
• Dispose of unused or expired medication as instructed by your healthcare provider.

What Drugs Interact with Leqvio? 

• Atorvastatin
• Rosuvastatin
• Simvastatin
• Pravastatin
• Lovastatin
• Warfarin
• Clopidogrel
• Digoxin
• Cyclosporine
• Tacrolimus
• Rifampin
• Ketoconazole
• Erythromycin
• Clarithromycin
• Diltiazem
• Verapamil
• Amiodarone
• Fluconazole
• Itraconazole
• Phenytoin
• Carbamazepine
• Phenobarbital
• St. John’s Wort
• Antiretroviral drugs (e.g., ritonavir, lopinavir)
• Fibrates (e.g., fenofibrate, gemfibrozil)

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

What Are the Leqvio Alternatives? 

• Statins:

• • • Lipitor (atorvastatin)
    • Crestor (rosuvastatin)
    • Zocor (simvastatin)
    • Pravachol (pravastatin)
    • Mevacor (lovastatin)

• PCSK9 Inhibitors:

• • • Praluent (alirocumab)
    • Repatha (evolocumab)

• Cholesterol Absorption Inhibitors:

• • • Zetia (ezetimibe)

• Bile Acid Sequestrants:

• • • Prevalite, Questran (cholestyramine)
    • Welchol (colesevelam)
    • Colestid (colestipol)

• Fibrates:

• • • Tricor, Lipofen (fenofibrate)
    • Lopid (gemfibrozil)

• Niacin (Vitamin B3):

• • • Niaspan, Slo-Niacin (niacin)

• Omega-3 Fatty Acids:

• • • Vascepa (icosapent ethyl)
    • Lovaza (omega-3-acid ethyl esters)

• Bempedoic Acid:

• • Nexletol (bempedoic acid)
  • Nexlizet (bempedoic acid and ezetimibe)

[Note: Your healthcare provider will choose which Leqvio alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]

Leqvio Cost & Coupons

The cost of Leqvio can vary significantly based on factors like health insurance coverage and the availability of assistance programs. Many Americans find that their insurance may not fully cover specialty medications like Leqvio, resulting in high out-of-pocket expenses. To make it more affordable, some turn to trusted service providers like Arctic Meds, which allows them to buy Leqvio online from Canada.

Frequently Asked Questions

Can Leqvio (inclisiran) cause hair loss?

No, hair loss was not reported as a side effect in clinical trials of Leqvio. If you experience hair loss while using this medication, consult your healthcare expert to see if there are other possible causes.

Can Leqvio be used without a statin?

This medication is FDA-approved as an add-on to diet and statin therapy for managing high cholesterol. However, research indicates it may still lower cholesterol when used without statins, particularly for individuals who cannot tolerate statins. Ongoing studies are evaluating its effectiveness as a standalone treatment. 

Does Inclisiran cause weight gain?

This medication itself doesn’t appear to cause weight changes. However, since it is often prescribed alongside statins, it’s worth noting that long-term use of statins has been associated with some weight gain, possibly due to dietary changes. To maximize the benefits of your cholesterol treatment plan and help manage your weight, it’s important to follow lifestyle recommendations like a heart-healthy diet and regular exercise.

How effective is Leqvio in lowering cholesterol?

Clinical studies show that Leqvio used with statin therapy significantly reduces “bad” cholesterol (LDL). Levels decreased after the first dose and were reduced by over 50% after 1.5 years of combined treatment. Regular cholesterol blood tests, as directed by your provider, will help monitor how well Leqvio is working for you. 

Our Guarantee

At Arctic Meds, we guarantee that you will find the most competitive prices to buy Leqvio through our platform. As the best Canadian online pharmacy, we are committed to delivering only the highest quality products. Each order is fulfilled through a reputable and licensed Canada pharmacy online, ensuring that every product we ship meets stringent standards of quality and authenticity. Our reliable service ships your medications directly from Canada right to your doorstep. To seamlessly buy Leqvio online from Canada at a low price, contact us.