Ketoprofen

Ketoprofen

Ketoprofen is an NSAID that effectively relieves pain and reduces inflammation for conditions like osteoarthritis, rheumatoid arthritis, and menstrual pain. Available in oral, topical, and injectable forms, it inhibits prostaglandins, which cause pain and inflammation. Common side effects include stomach discomfort and dizziness. Ketoprofen should be used with caution, especially in individuals with gastrointestinal, cardiovascular, or kidney issues. Always consult your healthcare provider before use.

Product Overview

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to alleviate pain, reduce inflammation, and manage symptoms of various conditions such as osteoarthritis, rheumatoid arthritis, and menstrual pain. Available in multiple forms, including oral capsules, topical gel, and injectable solutions, Ketoprofen provides versatile options for pain relief. It works by inhibiting the production of prostaglandins, chemicals responsible for inflammation, pain, and fever. Common side effects include stomach pain, nausea, dizziness, and drowsiness. Ketoprofen interacts with several medications, including anticoagulants, other NSAIDs, and diuretics, so discussing all medications with your healthcare provider is essential. Keep Ketoprofen at room temperature, away from moisture and direct sunlight for storage. Although practical, Ketoprofen should be used cautiously, particularly in patients with gastrointestinal, cardiovascular, kidney, or liver conditions. It’s also essential to avoid alcohol and monitor for any severe allergic reactions. Alternatives to Ketoprofen include ibuprofen, naproxen, and acetaminophen, among others.

Uses of Ketoprofen

• Osteoarthritis
• Rheumatoid arthritis
• Mild to moderate pain relief
• Menstrual pain (dysmenorrhea)
• Post-surgical pain management
• Pain and swelling from injuries (e.g., sprains, strains)

Benefits of Ketoprofen

• Reduces pain and inflammation
• Alleviates symptoms of arthritis
• Effective for mild to moderate pain
• It helps manage menstrual pain
• Provides relief from post-surgical pain

Side Effects of Ketoprofen

Common Ketoprofen side effects may include:

• Stomach pain or discomfort
• Nausea
• Indigestion
• Diarrhea
• Constipation
• Headache
• Dizziness
• Drowsiness
• Fluid retention
• Edema (swelling)
• Rash
• Itching
• Tinnitus (ringing in the ears)
• Increased sweating

[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]

Ketoprofen Dosage

Forms & Strengths

Forms & Strengths of Ketoprofen:

• Oral Capsules/Tablets:
  • 25 mg
  • 50 mg
  • 75 mg
  • 100 mg (extended-release)
  • 200 mg (extended-release)
• Topical Gel:
  • 2.5% concentration
• Injectable Solution:
  • 50 mg/mL
  • 100 mg/mL
• Suppositories:
  • 100 mg

Recommended Dosages

• For Osteoarthritis and Rheumatoid Arthritis:

  • Immediate-Release Capsules/Tablets: 50 mg to 75 mg three times daily or 75 mg twice a day.
  • Extended-Release Capsules/Tablets: 200 mg once daily.

• For Mild to Moderate Pain:

  • Immediate-Release Capsules/Tablets: 25 mg to 50 mg every 6 to 8 hours as needed. Maximum daily dose: 300 mg.

• For Menstrual Pain (Dysmenorrhea):

  • Immediate-Release Capsules/Tablets: 25 mg to 50 mg every 6 to 8 hours as needed.

• For Postoperative Pain:

  • Injectable Solution: 50 mg to 100 mg every 4 to 6 hours as needed.

• For Topical Use (Gel):

  • Topical Gel: Apply a thin layer of this medication to the affected area 2 to 3 times daily, as directed by a healthcare provider.

• For Pediatric Use:

  • The dosage of Ketoprofen varies based on the condition being treated and the child’s weight. Always consult a healthcare provider for appropriate dosing.

How to Take Ketoprofen?

• Take it with a full glass of water.
• To minimize stomach upset, take Ketoprofen with food or milk.
• Avoid crushing or chewing extended-release capsules/tablets.
• Follow your doctor’s dosage instructions carefully.
• Apply a thin layer of this medication to the affected area.
• Avoid application on cuts, wounds, or irritated skin.
• Wash hands thoroughly after application unless treating the hands.
• Avoid covering the treated area with bandages or dressings unless directed by a healthcare provider.
• Administered by a healthcare professional in a clinical setting.
• Doses are given via intramuscular or intravenous injection.
• Follow the instructions provided by your healthcare provider for proper insertion. Use as directed, typically once or twice daily.
• Take or apply Ketoprofen at the same time each day to maintain an even level in your system.
• Having alcohol can increase the risk of stomach bleeding when taking Ketoprofen.

Missed Dose 

If you miss a dose of Ketoprofen, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses of Ketoprofen at once to make up for the missed dose, as this can increase the risk of side effects of this medication. Consult your healthcare specialist for guidance if you’re unsure what to do.

[Note: Do not take two doses of Ketoprofen simultaneously to compensate for a missed dose. This can elevate your risk of experiencing Ketoprofen side effects.]

Overdose

An overdose of Ketoprofen can lead to serious health complications, including severe stomach pain, nausea, vomiting, dizziness, drowsiness, and even gastrointestinal bleeding or ulcers. In extreme cases, it may result in difficulty breathing, loss of consciousness, or kidney failure. If you suspect an overdose of Ketoprofen, seek immediate medical attention or call your local poison control center. Timely intervention is crucial to manage the symptoms and prevent potentially life-threatening complications.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Ketoprofen Work?

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the secretion of certain chemicals in the body known as prostaglandins. Prostaglandins are responsible for inflammation, pain, and fever as part of the body’s natural response to injury or illness. Ketoprofen blocks the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are necessary for the production of prostaglandins. By reducing the levels of these chemicals, Ketoprofen helps to alleviate pain, reduce inflammation, and lower fever, making it effective in treating conditions like arthritis, muscle pain, and other inflammatory conditions.

Important Safety Precautions

• Gastrointestinal risks: It may cause ulcers or bleeding.
• Cardiovascular risks: It Increases the risk of heart attack or stroke.
• Kidney function: This may impair kidney function; monitor regularly.
• Liver function: There may be potential liver damage; use cautiously.
• Allergic reactions: Ensure to watch for signs of severe allergy.
• Pregnancy/Breastfeeding: Avoid during late pregnancy; use with caution while breastfeeding.
• Asthma: It can worsen symptoms in sensitive individuals.
• Alcohol: This medication increases the risk of stomach bleeding; avoid.
• Driving/Machinery: It may cause dizziness or drowsiness; exercise caution.

Storage

• Store this medication at room temperature, between 20°C to 25°C.
• Keep in a dry place, away from moisture and humidity.
• Protect from direct sunlight and heat sources.
• Store in the original container or packaging to protect from light and contamination.
• Ensure the medicine is stored out of reach of children & pets.
• If using a liquid form, do not freeze it unless instructed by a healthcare provider.
• Do not use Ketoprofen past the expiration date on the label.

Ketoprofen Interactions

• Anticoagulants (e.g., Warfarin)
• Other NSAIDs (e.g., Ibuprofen, Aspirin)
• Corticosteroids (e.g., Prednisone)
• Diuretics (e.g., Furosemide, Hydrochlorothiazide)
• ACE Inhibitors/ARBs (e.g., Lisinopril, Losartan)
• Methotrexate
• Lithium
• Antiplatelet Agents (e.g., Clopidogrel)
• Cyclosporin
• Digoxin
• Probenecid

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions or supplements.]

Ketoprofen Alternatives

• Advil, Motrin (ibuprofen)
• Aleve, Naprosyn (naproxen)
• Voltaren (diclofenac)
• Celebrex (celecoxib)
• Mobic (meloxicam)
• Indocin (indomethacin)
• Tylenol (acetaminophen)
• Voltaren gel (diclofenac gel)
• Capsaicin cream
• Lidocaine patches
• Ultram (tramadol)
• Neurontin (gabapentin)
• Lyrica (pregabalin)
• Turmeric/Curcumin
• Omega-3 fatty acids
• Ginger
• Acupuncture
• Massage therapy
• Heat or cold therapy
• Corticosteroids (e.g., prednisone)

[Note: Your healthcare provider will choose which Ketoprofen alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is Ketoprofen the same as Ibuprofen?

Ketoprofen and ibuprofen (Advil) are nonsteroidal anti-inflammatory drugs (NSAIDs) that effectively reduce pain and inflammation. However, ketoprofen is available only by prescription, while ibuprofen (Advil) can be purchased over the counter or with a prescription. It’s important to consult with your healthcare provider to determine which over-the-counter option is most suitable for your needs.

Does Ketoprofen cause drowsiness?

Drowsiness can occur as a side effect of ketoprofen. Until you understand how the medication affects you, it’s advisable to avoid driving, operating heavy machinery, or engaging in activities that require full alertness.

How long does Ketoprofen take to work?

The immediate-rethin about 30 minutes after taking it. On the other hand, the extended-release capsule may take 2 to 3 hours to begin working. If you need faster pain relief, the immediate-release capsules are the better option.

Can Ketoprofen raise your blood pressure?

Yes, ketoprofen can raise your blood pressure. If you have high blood pressure, it’s essential to monitor it regularly, especially if you’re taking ketoprofen. If you notice consistently elevated readings, contact your healthcare provider immediately.

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