Finerenone
Buy Kerendia Online
Kerendia is a breakthrough oral medication for patients with type 2 diabetes or chronic kidney disease (CKD). It effectively reduces the progression of CKD and lowers the risk of cardiovascular events (CV) such as heart attacks and heart failure. Available in 10 mg & 20 mg tablets, Kerendia works by blocking mineralocorticoid receptors to prevent kidney deterioration and improve cardiac outcomes. Regular monitoring is required to manage potential side effects.
Product Overview
Kerendia (finerenone) is a non-steroidal mineralocorticoid receptor antagonist specifically created for individuals with type 2 diabetes and chronic kidney disease (CKD). This innovative medication is proven to significantly reduce the progression of CKD and lower the probability of cardiovascular events for instance heart attacks, heart failure hospitalization, and cardiovascular death. Available in oral tablet forms of 10 mg and 20 mg, Kerendia works by inhibiting the action of mineralocorticoid receptors, which play a crucial role in managing water and sodium balance in the body. This action helps to alleviate inflammation and fibrosis in the heart and kidneys, effectively slowing the deterioration of kidney function and reducing cardiovascular risks.
Kerendia’s side effects may include hyperkalemia, hypotension, and changes in kidney function, necessitating regular monitoring of kidney function and potassium levels by healthcare providers. Patients are advised to take Kerendia consistently as prescribed, with regular follow-up appointments to adjust dosages and ensure optimal treatment outcomes. Given its targeted approach, Kerendia represents a critical advancement in managing complex conditions associated with CKD and type 2 diabetes, offering a new hope for improving patient quality of life.
Uses of Kerendia
- Deterioration of kidney function
- Cardiovascular death
- Heart attack
- Hospitalization for heart failure
Benefits of Kerendia
- Reduces progression of chronic kidney disease in Type 2 diabetes patients.
- Lowers risk of cardiovascular death.
- Decreases the likelihood of heart attacks.
- Minimizes hospitalizations due to heart failure.
Side Effects of Kerendia
Common Kerendia side effects may include:
- Hyperkalemia (high potassium levels)
- Hypotension (low blood pressure)
- Decreased estimated glomerular filtration rate (eGFR)
- Nausea
- Vomiting
- Fatigue
- Weakness
- Itching
- Rash (less common)
- Anemia (decreased red blood cell count)
- Dehydration
[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]
Kerendia Dosage
Forms & Strengths
- Form: Oral tablets
- Strengths:
- 10 mg
- 20 mg
Recommended Dosages
For individuals with type 2 diabetes & chronic kidney disease (CKD), the recommended dosage of Kerendia (finerenone) is typically based on kidney function rather than a fixed weekly dosage. Here are the guidelines structured by the patient’s estimated glomerular filtration rate (eGFR):
Initial Dosage:
- Patients with an eGFR of ≥25 to <60 mL/min/1.73 m²: Start with 10 mg once daily.
- Patients with an eGFR of ≥60 mL/min/1.73 m²: Start with 20 mg once daily.
Adjustments:
- If a patient is also taking strong CYP3A4 inhibitors, adjust the dosage as follows:
- If currently taking 20 mg/day, reduce to 10 mg/day.
- If currently taking 10 mg/day, reduce to 10 mg every other day.
Maintenance Dosage:
- Continue with the adjusted dose based on patient response and the healthcare provider’s judgment. The aim is to manage the condition effectively while minimizing potential side effects.
How to Take Kerendia?
- Take Kerendia by mouth with or without food.
- Aim to take it simultaneously each day to maintain steady levels in your bloodstream.
- Take the dosage as prescribed by your healthcare provider, typically once daily.
- Do not crush, chew, or break the Kerendia tablet.
- Keep regular appointments for blood tests to monitor kidney function and potassium levels, as directed by your doctor.
- Maintain adequate hydration unless otherwise directed by your physician.
Missed Dose
If you miss a dose of Kerendia (finerenone), take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of Kerendia to compensate for the missed one, as this could increase your risk of side effects.
[Note: Do not take two doses of Kerendia simultaneously to compensate for a missed dose. This can raise your risk of experiencing side effects.]
Overdose
An overdose of Kerendia may exacerbate side effects like hyperkalemia (high potassium levels) and hypotension (low blood pressure). If you suspect an overdose of Kerendia, seek immediate medical attention. Medical professionals can provide necessary interventions and supportive care to manage symptoms and prevent complications.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Kerendia Work?
Kerendia works as a non-steroidal mineralocorticoid receptor antagonist (MRA). It specifically binds to and inhibits the mineralocorticoid receptor’s action, which regulates sodium and water balance. By blocking this receptor, Kerendia helps to reduce inflammation and fibrosis in the heart and kidneys. This can prevent the worsening of kidney disease and reduce cardiovascular risks, such as heart attacks and strokes, particularly in patients with type 2 diabetes and chronic kidney disease. This mechanism of action is beneficial in managing the progression of these conditions by controlling associated pathological changes without the typical steroid-related side effects.
Important Safety Precautions
- Regularly check kidney function, especially in patients with existing kidney issues, as Kerendia can affect renal performance.
- Monitor serum potassium levels frequently to prevent hyperkalemia, a common side effect.
- Do not use Kerendia in patients with severe renal impairment or end-stage kidney disease.
- Be cautious about drug interactions, especially with potent CYP3A4 inhibitors, which can increase Kerendia levels, and CYP3A4 inducers, which can decrease its effectiveness.
- Consult a medical specialist if you are pregnant, planning to conceive, or breastfeeding, as the effects of Kerendia on fetuses and infants are not well studied.
- Report any adverse effects, such as low blood pressure, dehydration, or changes in electrolyte levels, to your healthcare provider immediately.
- Schedule regular follow-up visits to monitor your response to the medication & adjust the dose if necessary.
- Kerendia should not be used in patients with adrenal insufficiency.
- Be aware of overdose symptoms and seek immediate medical attention if an overdose is suspected.
Storage
- Store Kerendia at room temperature, between 20°C to 25°C.
- Protect Kerendia from excessive heat and moisture. Do not store this medication in bathrooms or other damp places.
- Keep Kerendia in its original packaging until ready to use to protect it from light and moisture.
- Ensure that Kerendia is kept out of the reach of children & pets to prevent accidental ingestion.
- Pay attention to the expiration date on the package, and do not use past this date.
Kerendia Interactions
- Ketoconazole
- Itraconazole
- Ritonavir
- Clarithromycin
- Diltiazem
- Erythromycin
- Verapamil
- Fluconazole
- Rifampin
- Carbamazepine
- Phenytoin
- St. John’s Wort
- Phenobarbital
- Spironolactone
- Eplerenone
- Amiloride
- Triamterene
- Lisinopril
- Enalapril
- Ramipril
- Losartan
- Valsartan
- Irbesartan
- Ibuprofen
- Naproxen
- Diclofenac
- Celecoxib
- Tacrolimus
- Cyclosporine
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions or supplements.]
Kerendia Alternatives
- Aldactone (spironolactone)
- Inspra (eplerenone)
- Lotensin (benazepril)
- Vasotec (enalapril)
- Prinivil, Zestril (lisinopril)
- Altace (ramipril)
- Cozaar (losartan)
- Diovan (valsartan)
- Avapro (irbesartan)
- Benicar (olmesartan)
- Farxiga (dapagliflozin)
- Invokana (canagliflozin)
- Jardiance (empagliflozin)
- Ozempic (semaglutide)
- Trulicity (dulaglutide)
- Victoza (liraglutide)
- Norvasc (amlodipine)
- Cardizem (diltiazem)
- Procardia (nifedipine)
- Lasix (furosemide)
- Bumex (bumetanide)
- Demadex (torsemide)
[Note: Your healthcare provider will choose which Kerendia alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
How effective is Kerendia?
In clinical studies, Kerendia demonstrated an 18% reduction in the risk of worsening kidney function and a 14% reduction in the risk of heart-related issues, for example heart attack, stroke, heart failure hospitalization, and cardiovascular death, compared to those taking a placebo.
How can I tell if Kerendia is working for me?
Kerendia is designed to help prevent further kidney and heart issues, so you won’t be able to “feel” its effects directly. Your healthcare specialist will regularly monitor your progress during treatment and determine whether to continue or adjust your medication based on your overall health and test results.
Will I need blood tests before starting Kerendia?
Yes, your healthcare provider will order blood tests to assess your kidney function and blood potassium levels, determine if Kerendia is suitable for you, and establish the correct dosage. During treatment, regular monitoring of your kidney function and potassium levels will continue, with potential adjustments to your dose or discontinuation of the medication based on the results.
Can I use Kerendia if I’m pregnant?
There are no studies on the effects of Kerendia in human pregnancies. Still, animal studies have shown developmental problems in babies when pregnant animals were given doses about four times higher than those used in humans. If you are pregnant or planning to become pregnant, it’s important to discuss the potential risks and benefits with your medical professional before starting Kerendia.
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