Sitagliptin/Metformin
Sitagliptin-Metformin
Buy Janumet XR Online
Janumet XR combines two medicines to effectively manage high blood glucose levels in patients with type 2 diabetes mellitus. This medication is usually advised along with a proper diet and exercise program. Besides managing sugar levels, it prevents serious complications of diabetes like kidney damage and blindness and reduces the risk of cardiovascular events like heart attack or stroke. This medication is not prescribed to everyone. So, discuss with your doctor if you have any medical history of kidney, liver, or heart problems.
Product Overview
Janumet XR is an extended-release formulation that combines two effective ingredients, sitagliptin and metformin hydrochloride. Sitagliptin is a DPP-4 inhibitor that increases incretin levels, improving insulin release and decreasing glucagon levels, while metformin reduces glucose production in the liver and improves insulin sensitivity. These ingredients work simultaneously to provide better glycemic control in adults with type 2 diabetes.
The medication is available in varying strengths to meet individual patient needs. It should be taken once daily with a meal to reduce gastrointestinal side effects. It is suitable for adults diagnosed with type 2 diabetes, particularly those who require additional glycemic control beyond diet and exercise alone or in combination with other diabetes medications. The extended-release nature of Janumet XR helps maintain stable blood sugar levels throughout the day, ensuring consistent management of diabetes.
Like every medicine, Janumet XR has some side effects, which may include nausea or diarrhea. Precautions should be taken for those with renal impairment, and regular monitoring is advised. If a dose is missed, it should be taken as soon as remembered unless it is close to the next dose. In case of overdose, seek immediate medical attention.
Uses of Janumet XR
This prescription drug is used for:
- Managing type 2 diabetes
- Preventing kidney damage and blindness
- Reducing the risk of heart attacks or strokes
Benefits of Janumet XR
- Janument XR/ ER (Extended-Release) offers a convenient once-daily option, making it easier for patients to incorporate it into their daily routines.
- Helps in achieving better glycemic control when combined with diet and exercise.
- Do not cause weight gain or loss.
- Lower risk of hypoglycemia compared to other diabetes medications.
- It can be used as monotherapy or in combination with other diabetes medications.
Side Effects of Janumet XR
Common side effects of Janumet XR may include:
- Not feeling hungry
- Vomiting
- Upper respiratory tract infection
- Hypoglycemia (low blood glucose level)
- Abdominal bloating
- Nausea
- Diarrhea
- Headache
- Joint pain
- Change in the amount of urine
- Skin blisters
- Difficulty in breathing
- Swelled ankles or feet
- Dizziness
[Note: This list is not exhaustive; if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]
Janumet XR Dosage
Forms & Strengths
Janumet XR comes in a tablet form with the following strengths
- 50 mg of sitagliptin/500 mg of metformin ER.
- 50 mg of sitagliptin/1,000 mg of metformin ER.
- 100 mg of sitagliptin/1,000 mg of metformin ER.
Recommended Dosages
- Janumet XR is usually prescribed to adults with type 2 diabetes for once-daily use.
- Patients who are not taking metformin are advised to take 100 mg of sitagliptin and 1000 mg of metformin hydrochloride (HCl) Extended-Release.
- Patients who are taking 500 mg of metformin two times a day are usually recommended to take 100 mg of sitagliptin and 1000 mg of metformin ER once a day.
- For patients who are already taking 850 mg of metformin twice daily, two tablets of 50 mg sitagliptin and 1000 mg metformin ER can be taken.
- If patients take 1000 mg of metformin twice daily, they are advised to take two tablets of 50 mg sitagliptin and 1,000 mg metformin ER.
How to Take Janumet XR?
- Read the medication guide thoroughly before you start using this medication or before buying a new one.
- Take it orally or as your doctor directs, usually once a day with a meal to avoid upset stomach.
- Swallow the tablets as a whole for quick absorption.
- Do not crush, chew, or break the tablets.
- Drink enough water while taking the medication.
- Take the medication regularly for better results.
- Follow the medication treatment, meal, and exercise plan your doctor recommends.
- If you are facing difficulty swallowing the medication, seek medical assistance.
Missed Dose
- If you forget to take your medication, do not panic; try to take the missed dose as soon as you remember.
- If it is almost time for your next dose, continue your regular dosing schedule and skip the missed one.
- Do not take double doses to catch up with your missed dose.
- Use medication apps or reminders to avoid skipping any medication.
[Note: Do not take two doses of Janumet XR at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]
Overdose
It is usually advised not to exceed the dosage of your medication, but if someone has taken an excessive amount of Janumet XR, seek medical assistance right away. In certain cases, patients have reported hypoglycemia, but it’s unclear if metformin caused it. So, if you are experiencing any symptoms like nausea, sweating, weakness, tremors, or seizures, get medical help or call 911.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Janumet XR Work?
Janumet XR/ER (Extended Release) is a combination of two medicines, namely sitagliptin and metformin. The former medicine supports your pancreas in forming more insulin, thus promoting the effective use of insulin by the body. It also reduces the surplus sugar produced by your liver. At the same time, metformin, a biguanide, lowers glucose production in the liver, delays its absorption from the intestines, and improves the body’s insulin sensitivity. Together, these actions provide better blood sugar regulation.
Important Safety Precautions
- Excessive accumulation of metformin in the body can cause fatal conditions like lactic acidosis. It is more prevalent in patients with kidney problems, liver issues, dehydration, heart failure, too much intake of alcohol, and older adults. If you have acidosis, discontinue the medication immediately.
- If you are allergic to any of the medications’ ingredients, inform your doctor. The product may contain certain inactive components that can cause severe allergic reactions.
- If you have a medical history of breathing problems, liver or kidney disease, pancreatitis, gallstones, or any blood problems, talk to your medical provider.
- If you are undergoing any surgery, tell your healthcare practitioner about all the products you use, including prescription drugs, nonprescription drugs, and herbal products.
- Metformin can cause fluctuations in the menstrual cycle and increase the risk of pregnancy, So consult with an expert about the usage of reliable birth control while using Janumet XR.
- Do not take this medication during pregnancy or breastfeeding without discussing it with a medical professional, as it can cause harm to the baby.
- Closely monitor your blood and urine tests, especially during the starting weeks of the treatment.
- If you are taking other medicines while using Janumet XR, there is a high chance that you may experience hypoglycemia. Talk to your medical practitioner, they will examine you and may suggest ways to treat low blood sugar.
Storage
- Store the medication at 20-25°C.
- Keep it out of reach of children.
- Keep the medicines in a dry place with a tightly closed cap.
- Discard the medication when it is not in use.
- Read the product’s label carefully.
- Ask your medical practitioner how to dispose of the product properly.
Janumet Interactions
- Zonisamide
- Acetazolamide
- Amiloride
- Digoxin
- Morphine
- Procainamide
- Quinidine
- Quinine
- Ranitidine,
- Triamterene
- Trimethoprim
- Glimepiride
- Hydrochlorothiazide
- Furosemide
- Levothyroxine
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
Janumet XR Alternatives
- Metformin
- Ozempic
- Rybelsus
- Mounjaro
- Semaglutide
- Tirzepatide
- Januvia
- Victoza
[Note: Your healthcare provider will choose which Janumet XR alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
Is Janumet & Janumet XR the same?
Janumet and Janumet XR contain the same active ingredients, sitagliptin and metformin. However, Janumet XR is an extended-release version that provides a longer duration of action. As a result, patients do not have to take frequent doses as compared to the regular Janumet.
When not to use Janumet XR?
Avoid using Janumet XR if you have severe kidney disease, metabolic acidosis, or a known allergy to sitagliptin or metformin. The medication is also not recommended during diabetic ketoacidosis or if you have a history of lactic acidosis.
Can I take Janumet XR and Metformin at the same time?
While no interaction was found between Janumet XR and metformin, you are advised not to take additional metformin with your medication as it already contains metformin. Therefore, it is always a better idea to consult your healthcare provider for personalized medical advice regarding dosage and medication combinations.
Can I eat eggs while taking Janumet XR?
Yes, you can eat eggs while taking Janumet XR. Eggs do not interfere with the medication’s effectiveness and can be part of a balanced diet for managing blood sugar levels. They are a good source of high-quality protein and essential nutrients. So, including them in your meals helps maintain stable sugar levels.
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