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Sitagliptin & Metformin
Janumet
Janumet is an FDA-approved prescription medication for treating type 2 diabetes mellitus. It contains two substances, sitagliptin and metformin, that effectively work to control blood sugar levels. It is available in the form of a tablet with two different strengths. The dosage depends on your age, needs, and other medications you may be taking. You should consult your doctor or healthcare provider for personalized guidance and advice. You can buy Janumet to treat type 2 diabetes from the convenience of your home at the best prices through a reliable and trusted online Canadian pharmacy.
Product Overview
Janumet is a combination medication that contains two active ingredients: sitagliptin and metformin. Sitagliptin is a dipeptidyl-peptidase-4 inhibitor that regulates insulin levels post-meal, while metformin, a biguanide, reduces glucose production in the liver and absorption in the intestines. This medication is primarily used to manage Type 2 diabetes mellitus by effectively controlling blood sugar levels.
Janumet is available in tablet form with strengths of 50 mg of sitagliptin/1000 mg of metformin and 50 mg of sitagliptin/500 mg of metformin. It is typically prescribed for adults alongside a proper diet and exercise regimen. The dosage varies based on prior metformin use: 50 mg of sitagliptin/500 mg of metformin twice daily for new users and 50 mg of sitagliptin/1000 mg of metformin twice daily for those already on metformin.
Common side effects include abdominal bloating, diarrhea, hypoglycemia, nausea, reduced appetite, respiratory infections, and vomiting. To minimize risks, avoid alcohol, monitor blood sugar levels, and inform healthcare providers of all medications. If a dose is missed, take it promptly unless it’s near the next dose. Store Janumet in a cool, dry place away from children and dispose of it properly.
Uses of Janumet
It is used in treating and managing:
- Type 2 diabetes mellitus
Benefits of Janumet
- It is beneficial in regulating blood sugar levels.
- Controlling your blood sugar levels will reduce the risk of severe complications associated with diabetes, such as eye problems, nerve damage, kidney-related issues, and loss of limbs.
- Taking this medication, along with a proper diet plan and regular exercise, will help you lead a healthy and balanced life.
Side Effects of Janumet
Common side effects of Janumet may include:
- Abdominal bloating
- Diarrhea
- Hypoglycemia
- Nausea
- Reduced appetite
- Upper respiratory tract infection
- Vomiting
[Note: This list is not exhaustive; if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]
Janumet Dosage
Forms & Strengths
It comes in the form of a tablet with the following strengths:
- 50 mg of sitagliptin/500 mg of metformin
- 50 mg of sitagliptin/1000 mg of metformin
Recommended Dosages
Dosage for Type 2 Diabetes Patients
- Daily recommended dose (when you have never taken metformin): 50 mg of sitagliptin/500 mg of metformin twice daily.
- Daily recommended dose (when taking metformin): 50 mg of sitagliptin/1000 mg of metformin twice daily.
- Maximum daily dose: 100 mg of sitagliptin/2000 mg of metformin
How to Take Janumet?
- Janumet is typically prescribed alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes.
- Carefully read and follow the instructions for use that came along with your prescription label for safe and efficient use of the medication.
- If you have any queries or concerns regarding the medication use, consult your doctor.
- Take Janumet at the dose and duration advised by your doctor. Do not take it more frequently than prescribed or in larger amounts.
- Do not crush, chew, or break the Janumet tablet. Swallow it whole. If you have difficulty swallowing the medication, let your doctor know.
- You should carefully monitor your blood sugar levels while taking this medication and share the report with your doctor to determine how it works for you. If you have high or low blood glucose levels, you may require adjustments in dosage and diet.
- If you plan to have surgery, including a dental procedure, you should let your doctor, surgeon, or dentist know about all your medications, including Janumet. Also, tell them about all the prescription medications, over-the-counter drugs, and herbal supplements you may be taking.
- Janumet is meant to be taken for the long term. If your doctor determines that this medication is safe and effective, you are most likely to take it for the long term.
Missed Dose
If you have missed a dose of Janumet, you should take it as soon as you remember. However, If it’s nearly time for your next dose, you may omit the missed dose and continue as per your regular dosing schedule. Do not take double or extra doses of the same medication to compensate for the missed dose. You can try setting a reminder on your phone to prevent missing your medication dosage.
[Note: Do not take two doses of Janumet at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]
Overdose
Do not take this medication more than recommended, as it may lead to hypoglycemia. Symptoms may include nausea, extreme fatigue, tremors, sweating, confusion, difficulty speaking, rapid heartbeats, or seizures. If you experience any of these symptoms, seek immediate medical attention. You can call 911 or head to the nearest emergency room.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Janumet Work?
Janumet is a combination medication containing two active ingredients: metformin and sitagliptin. Metformin belongs to biguanide class that helps control blood sugar levels by decreasing the production of glucose in the liver and reducing glucose absorption by the intestines. Sitagliptin is a DPP-4 inhibitor that regulates insulin levels produced by the pancreas after eating.
Important Safety Precautions
- Do not consume alcohol while receiving treatment with Janumet, as it can affect your blood sugar levels.
- This medication may be unsafe to use during pregnancy. Let your doctor know if you think you may be pregnant, suspect a pregnancy, or are planning to become pregnant. Before prescribing this medication, your doctor will weigh the benefits and potential risks.
- Janumet may be unsafe to take while breastfeeding a baby as it may pass into breast milk and cause harm to the infant.
- This medication should be used cautiously in patients with kidney and liver disease. They may require an adjustment in diet and dosage. You should consult your doctor before using this medication if you have liver, kidney, or heart-related conditions.
- This medication is not approved for use by individuals younger than 18 years old.
- This medication may affect your vision and ability to concentrate. Do not drive, operate heavy machinery, or indulge in activities requiring your attention and clear vision unless you determine how this medication may affect you.
- Discontinue taking this medication and call your doctor immediately if you experience any signs and symptoms of lactic acidosis, such as drowsiness, chills, unusual fatigue, muscle pain, difficulty breathing, slow or irregular heartbeat, or abdominal pain with vomiting/nausea, or diarrhea.
- While taking this medication, watch out for signs of hypoglycemia and hyperglycemia and measure your blood sugar levels frequently.
Storage
- Keep Janumet in a tightly closed container in a cool and dry place, away from direct sunlight, moisture, and excess heat.
- Do not keep it in the bathroom.
- Keep all medications, including Janumet, away from the sight and reach of children.
- Do not keep medications that are outdated or no longer needed. Discard them safely
- Do not pour unwanted medications down the drain, throw them in the household dustbin, or flush them down the toilet.
- Discard the medications so children, animals, and others cannot consume them.
- Consult your pharmacist, healthcare provider, and local waste disposal company to learn how to properly eliminate unwanted medications.
Janumet Interactions
- Antidiabetic medications
- Anti-seizure medications
- Antipsychotic medications
- Antacid
- Corticosteroid
- Dichlorphenamide
- Estrogen
- HIV protease inhibitors
- Heart or blood pressure medications
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
Janumet Alternatives
- Glipizide (glipizide)
- Insulin glargine (glargine)
- Januvia (sitagliptin)
- Jardiance (empagliflozin)
- Metformin
- Nesina
- Rybelsus (semaglutide)
- Victoza (liraglutide)
[Note: Your healthcare provider will choose which Janumet alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
How does Janumet differ in effectiveness from Metformin alone for Type 2 diabetes?
Janumet combines sitagliptin and metformin, offering dual action to enhance insulin secretion post-meal and reduce glucose production, potentially improving glycemic control beyond metformin alone.
Can Janumet be used in patients with renal impairment?
Janumet requires dosage adjustments or may not be recommended for patients with renal issues. Kidney function must be evaluated before and periodically after initiating treatment.
What should I monitor while taking Janumet to prevent side effects?
Monitoring blood glucose levels, kidney function tests, and signs of gastrointestinal distress while taking Janumet is crucial for effectively managing side effects.
How long does it take for Janumet to show effects on blood sugar levels?
The effects of Janumet on blood sugar levels can be observed within the first few weeks of treatment, with maximum benefits typically seen after prolonged regular use.
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