Guanfacine Extended-Release

Buy Intuniv Online

Intuniv is specifically designed to treat ADHD in children aged 6-17. It targets brain receptors to improve focus, reduce impulsivity, and enhance cognitive functions. Available in 1-4 mg tablets for daily oral use, it requires careful dosage management. Although primarily for ADHD, it’s also used off-label for lowering blood pressure. Always consult a healthcare provider before use.

Product Overview

Intuniv (guanfacine extended-release) is a non-stimulant medication specifically approved to treat Attention Deficit Hyperactivity Disorder (ADHD) in children & adolescents aged 6 to 17. By activating alpha-2A adrenergic receptors in the brain, Intuniv enhances concentration, reduces impulsivity, and improves overall cognitive functions, making daily activities more manageable for those with ADHD. Additionally, it has shown off-label benefits in lowering high blood pressure.

Available in extended-release tablets ranging from 1 mg to 4 mg, Intuniv is designed for once-daily oral administration. It can be taken with or without food, preferably in the morning, to prevent interference with sleep due to its potential side effects, such as drowsiness, headache, and abdominal pain.

For optimal results, the dosage is typically initiated at 1 mg and adjusted based on therapeutic response and tolerability, with a maximum limit of 4 mg per day. Patients are advised not to discontinue the medication abruptly to avoid withdrawal symptoms and to ensure consistent management of ADHD symptoms. Always consult with a medical specialist for personalized guidance and monitoring.

Uses of Intuniv 

• Attention Deficit Hyperactivity Disorder (ADHD)
• Treatment of hypertension (off-label use)

Benefits of Intuniv 

• Reduces symptoms of ADHD
• Enhances concentration
• Decreases impulsivity
• Improves attention span
• Can lower blood pressure (off-label benefit)

Side Effects of Intuniv

Common Intuniv side effects may include:

• Drowsiness
• Fatigue
• Headache
• Dizziness
• Irritability
• Abdominal pain
• Dry mouth
• Constipation
• Decreased appetite
• Sleep disturbances

[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]

Intuniv Dosage

Forms & Strengths

Intuniv (guanfacine extended-release) is available in several forms and strengths, tailored for varying dosage requirements:

• Tablets (Extended-Release):

• • 1 mg
  • 2 mg
  • 3 mg
  • 4 mg

Recommended Dosages

Children and Adolescents (Ages 6-17):

• Initial Dosage: Start with 1 mg once daily.
• Titration: Increase by 1 mg per week, depending on response and tolerability.
• Maintenance Dosage: Typically, 1 to 4 mg once daily.
• Maximum Dosage: Should not exceed 4 mg per day.

Adults:

• There are no specific dosing guidelines for adults, as Intuniv is not FDA-approved for adult ADHD. However, if used off-label, the dosing might mirror that used in adolescent populations.

Special Considerations:

• Renal Impairment: Adjustments may be required based on kidney function.
• Hepatic Impairment: Use with caution and consider dose adjustments.

How to Take Intuniv?

• Take Intuniv precisely as prescribed by your healthcare provider, usually once daily.
• Swallow the Intuniv tablet whole with water; do not crush, chew, or break it.
• Take Intuniv at the same time each day, preferably in the morning.
• You can take it with or without food, but be consistent with your choice to maintain even medication levels.
• Do not suddenly stop taking Intuniv without consulting your medical professional, as this can lead to withdrawal symptoms.
• Routinely follow up with your healthcare expert to monitor your response & adjust the dosage if necessary.

Missed Dose 

If you miss a dose of Intuniv, take it at the earliest moment you remember. However, if it’s close to your next scheduled dose of Intuniv, skip the missed dose and continue with your regular dosing schedule. Do not take two doses simultaneously to make up for the missed dose. 

[Note: Do not take two doses of Intuniv simultaneously to compensate for a missed dose. This can elevate your risk of experiencing side effects.]

Overdose

An overdose of Intuniv (guanfacine) can be severe and may lead to symptoms such as drowsiness, dizziness, low blood pressure, slow heart rate, fatigue, and possible fainting. In severe cases, overdose can lead to respiratory depression, confusion, or even loss of consciousness. 

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Intuniv Work?

Intuniv (guanfacine) works by targeting alpha-2A adrenergic receptors in the brain. This action helps regulate the part of the brain responsible for attention, impulse control, and memory. By stimulating these receptors, Intuniv improves focus, reduces impulsivity, and enhances overall cognitive function, effectively managing symptoms of attention deficit hyperactivity disorder (ADHD). Unlike stimulant medications, Intuniv is non-stimulant and works gradually to provide sustained symptom control throughout the day.

Important Safety Precautions 

• Monitor blood pressure regularly, as Intuniv can cause hypotension and bradycardia.
• Watch for signs of sedation or drowsiness, especially when starting treatment or adjusting the dose.
• Be cautious about potential interactions with other CNS depressants and medications affecting blood pressure.
• Avoid abrupt discontinuation to prevent withdrawal symptoms, such as increased heart rate and blood pressure.
• Practice caution when operating machinery or driving until you know how Intuniv affects you.
• Consult a healthcare provider before using if pregnant or breastfeeding.
• Store the medication away from children and never share it with others, especially those with a history of drug abuse or addiction.

Storage 

• Keep at room temperature, between 68°F to 77°F (20°C to 25°C).
• Store Intuniv in the original container to protect it from light and moisture.
• Keep the container tightly closed when not in use.
• Place in a safe location out of reach of children and pets.
• Avoid storing this medication in areas prone to high humidity, like bathrooms.

Intuniv Interactions

• CNS depressants (e.g., benzodiazepines, opioids, alcohol)
• Antihypertensives (e.g., beta-blockers, ACE inhibitors, diuretics)
• CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
• CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John’s Wort)
• Valproic acid (e.g., Depakote)
• Barbiturates (e.g., phenobarbital)
• Antiepileptic drugs (e.g., phenytoin, lamotrigine)
• Digoxin
• Lithium
• Antipsychotics (e.g., risperidone, quetiapine)
• SSRIs (e.g., fluoxetine, sertraline)
• SNRIs (e.g., venlafaxine, duloxetine)
• Tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
• MAO inhibitors (e.g., phenelzine, tranylcypromine)
• Beta-blockers (e.g., propranolol, metoprolol)
• Clonidine (another alpha-2 agonist)
• ACE inhibitors (e.g., lisinopril, enalapril)
• ARBs (e.g., losartan, valsartan)
• Diuretics (e.g., furosemide, hydrochlorothiazide)
• Calcium channel blockers (e.g., amlodipine, verapamil)
• Nitrates (e.g., nitroglycerin)
• Insulin and other antidiabetic drugs
• Corticosteroids (e.g., prednisone)
• NSAIDs (e.g., ibuprofen, naproxen)
• Stimulants (e.g., methylphenidate, amphetamines)
• Macrolide antibiotics (e.g., erythromycin, clarithromycin)
• Antifungal agents (e.g., fluconazole, voriconazole)
• HIV protease inhibitors (e.g., indinavir, saquinavir)
• Benzodiazepines (e.g., diazepam, lorazepam)
• Sedating antihistamines (e.g., diphenhydramine, hydroxyzine)
• Opioid analgesics (e.g., morphine, oxycodone)
• Muscle relaxants (e.g., cyclobenzaprine)
• General anesthetics
• Alpha-blockers (e.g., tamsulosin, doxazosin)
• Caffeine (may increase side effects such as jitteriness)
• Smoking (can reduce the effectiveness of Intuniv)

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Intuniv Alternatives 

• Stimulants:
  • Methylphenidate (e.g., Ritalin, Concerta [methylphenidate])
  • Amphetamines (e.g., Adderall [mixed amphetamine salts], Vyvanse [lisdexamfetamine])
• Non-stimulants:
  • Strattera [atomoxetine]
  • Kapvay [clonidine]
  • Wellbutrin [bupropion]
• Other alpha-2 agonists:
  • Clonidine (similar mechanism to guanfacine)
• Antidepressants (off-label use):
  • Tricyclic antidepressants (e.g., Tofranil [imipramine], Norpramin [desipramine])
  • SSRIs (e.g., Prozac [fluoxetine], Zoloft [sertraline])
• Natural supplements (limited scientific evidence):
  • Omega-3 fatty acids
  • Zinc
  • Iron (in cases of deficiency)
• Behavioral therapies:
  • Cognitive Behavioral Therapy (CBT)
  • Behavioral management techniques

[Note: Your healthcare provider will choose which Intuniv alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions 

How long does Intuniv take to show effects?

The effects of Intuniv may take several weeks to become apparent. Initially, treatment typically starts at a low dosage, such as 1 mg, to reduce the likelihood of side effects. Your healthcare specialist may gradually increase the dosage over several weeks, depending on your tolerance and response to the medication, until the optimal therapeutic dose is reached.

Is Intuniv effective for treating anxiety?

While Intuniv is officially approved only for treating ADHD, some research indicates it may also alleviate anxiety symptoms in children and adolescents. However, more comprehensive studies are needed to fully comprehend its efficacy in treating anxiety. If you’re considering guanfacine ER for anxiety, consult with a healthcare expert to explore suitable treatment options.

Is Intuniv suitable for adults?

According to the 2012 ADHD treatment guidelines, Intuniv is officially approved for treating ADHD in children aged 6 to 17, but it is not recommended for adults. Some studies have showcased its potential benefits for adult ADHD symptoms like attention and hyperactivity, yet the evidence remains insufficient to confirm its effectiveness in adults. For more information on adult ADHD treatments, it’s best to consult with a healthcare provider.

What is the difference between guanfacine (Tenex) and guanfacine ER (Intuniv)?

Guanfacine (Tenex) is an immediate-release form of guanfacine approved to manage high blood pressure, while guanfacine ER (Intuniv) is an extended-release form approved explicitly for treating ADHD in children and adolescents. Both forms are administered orally once daily and are known to cause significant drowsiness. It’s important to consult your healthcare expert to determine the appropriate medication and formulation for your condition, as these two medications are not interchangeable.

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