Estradiol Vaginal Inserts

Buy Imvexxy Online

Imvexxy offers targeted relief for postmenopausal women suffering from vaginal dryness and dyspareunia due to vulvar and vaginal atrophy. Available in 4 mcg and 10 mcg doses, it provides practical, low-dose estrogen treatment directly to affected areas, ensuring minimal systemic absorption and fewer side effects. It is ideal for managing menopausal symptoms with a convenient twice-weekly dosing schedule.

Product Overview

Imvexxy (estradiol vaginal inserts) is a hormone replacement therapy explicitly designed for postmenopausal women experiencing moderate to severe dyspareunia due to vulvar & vaginal atrophy. Available in vaginal insert forms of 4 mcg and 10 mcg, Imvexxy provides effective relief from menopausal symptoms like vaginal dryness, itching, and burning by delivering a low dose of estrogen directly to the affected area. This localized application helps to rejuvenate and maintain vaginal tissue health with minimal systemic absorption, reducing the potential for side effects associated with other hormone therapies.

Starting with a daily application of the 4 mcg insert for two weeks followed by a maintenance schedule of twice weekly, Imvexxy offers a convenient treatment regimen. It is specifically designed to have minimal impact on overall hormone levels, providing a safer profile for those with hormone-sensitive conditions. Common side effects include vaginal irritation and headache. Patients should discuss their medical history with their medical professional before starting treatment to ensure safety, particularly regarding potential interactions with other medications.

Uses of Imvexxy

• Menopausal symptoms
• Vaginal dryness
• Vaginal atrophy

Benefits of Imvexxy 

• Effective relief from menopausal symptoms, particularly vaginal dryness, itching, and burning.
• Convenient, low-dose formulation that minimizes exposure to estrogen.
• Direct application to the affected area maximizes local benefit.
• It may improve quality of life and comfort during menopause.
• Designed to have minimal impact on overall hormone levels, potentially offering a safer profile for hormone-sensitive conditions.

Side Effects of Imvexxy 

Common Imvexxy side effects may include:

• Vaginal irritation
• Dryness or discomfort
• Headache
• Nausea
• Mood changes
• Abdominal pain

[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]

Imvexxy Dosage

Forms & Strengths

• Vaginal inserts: 4 mcg, 10 mcg

Recommended Dosages

The recommended dosages of Imvexxy for the management of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy due to menopause, are as follows:

• Initial Dosage: Start with the 4 mcg vaginal insert once daily for two weeks.
• Maintenance Dosage: After the initial daily two-week period, continue with one 4 mcg vaginal insert twice a week.

How to Take Imvexxy?

• Administer at the Same Time Daily: For the initial two-week treatment phase, insert one capsule daily.
• Twice-Weekly Schedule: After the initial phase, continue with twice-weekly dosing.
• Proper Insertion: Use the provided applicator to insert the capsule deeply into the vagina.
• Hygiene: Wash your hands before and after inserting the capsule.

Missed Dose 

If you miss a dose of Imvexxy, take it as soon as you remember. However, if it’s close to your next dose, skip the missed dose and resume your usual dosing schedule. Do not double up doses of this medication to make up for the missed one. If unsure, consult your healthcare provider for specific guidance based on your treatment plan.

[Note: Do not take two doses of Imvexxy simultaneously to compensate for a missed dose. This can increase your risk of experiencing side effects.]

Overdose

An overdose of Imvexxy (estradiol vaginal inserts) may not lead to life-threatening symptoms, but it could exacerbate side effects such as nausea, vomiting, withdrawal bleeding, and breast tenderness. If you suspect an overdose of Imvexxy, contact your healthcare provider or local poison control center immediately for guidance on how to proceed. In cases where symptoms are severe, seek emergency medical attention.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Imvexxy Work?

Imvexxy, a brand name for estradiol vaginal inserts, works by delivering a form of estrogen directly to the vaginal tissue. It is specifically designed to treat menopausal symptoms such as vaginal dryness, itching, and burning, which are often caused by the natural decrease in estrogen levels during menopause. The medication helps to rejuvenate and maintain the health of vaginal tissues by restoring the average balance of estrogen. This local application allows for the therapeutic effects of estrogen with minimal systemic absorption, meaning it primarily affects only the area to which it is applied, reducing the risk of side effects associated with oral or systemic hormone therapies.

Important Safety Precautions

• Consult Healthcare Provider: Discuss your medical history & current medications with your healthcare expert before starting Imvexxy.
• Monitor for Side Effects: Watch for side effects such as unusual bleeding, discharge, headache, or mood changes.
• Avoid Pregnancy: Imvexxy is not intended for use during pregnancy. Use effective contraception if you are of childbearing age.
• Report Unusual Symptoms: Contact your healthcare provider if you experience any unusual symptoms or severe reactions.
• Routine Check-ups: Schedule regular follow-up visits with your healthcare specialist to monitor your response to the medication and adjust dosage if necessary.
• Drug Interactions: Inform your healthcare expert about all other medications you are taking to avoid potential drug interactions.

Storage 

• Keep at room temperature, between 68°F to 77°F (20°C to 25°C).
• Do not store in extreme heat or cold.
• Keep it in its original container or blister pack until use.
• Store in a dry place, away from moisture.
• Keep away from children and pets.

Imvexxy Interactions 

• Estrogen Interactions: May interact with other estrogen-containing medications.
• Anticoagulants: Use with blood thinners like warfarin may increase bleeding risk.
• Anticonvulsants: Some may reduce Imvexxy effectiveness.
• Certain Antibiotics: May affect the absorption or effectiveness of Imvexxy.
• Grapefruit Juice: Can alter drug metabolism, affecting Imvexxy levels.

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Imvexxy Alternatives

• Other vaginal estrogen products:
  • Vagifem (estradiol)
  • Estring (estradiol)
  • Premarin Vaginal Cream (conjugated estrogens)
  • Estrace Vaginal Cream (estradiol)
• Oral hormone therapy:
  • Premarin (conjugated estrogens)
  • Estrace (estradiol)
  • Menest (esterified estrogens)
  • Cenestin (synthetic conjugated estrogens)
• Transdermal hormone therapy:
  • Vivelle-Dot (estradiol patch)
  • Climara (estradiol patch)
  • Estrogel (estradiol gel)
  • Divigel (estradiol gel)
• Non-hormonal options:
  • Replens (moisturizer)
  • K-Y Jelly (lubricant)
  • Revaree (hyaluronic acid suppositories)
  • Intrarosa (prasterone)
• Systemic non-hormonal medications:
  • Osphena (ospemifene)
  • Brexafemme (ibrexafungerp)

[Note: Your healthcare provider will choose which Imvexxy alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

How quickly does Imvexxy begin to take effect?

Imvexxy begins to take effect from the first dose, but it generally takes around 2 weeks to notice the initial benefits. For some individuals, achieving the full therapeutic effects may require up to 3 months of consistent use. If you continue to experience discomfort during intercourse beyond this period, it is important to consult with your doctor to assess whether Imvexxy is appropriate for your treatment needs.

Are the dosages for Imvexxy and Vagifem similar?

Yes, both Imvexxy and Vagifem are administered similarly to vaginal inserts, initially daily for two weeks, followed by twice weekly. Imvexxy is available in 4 mcg and 10 mcg dosages, whereas Vagifem is available only in a 10 mcg dosage. Each medication includes unique applicators, with Vagifem utilizing one for insertion. Your medical professional will determine the specific dosage and treatment for your needs.

How do you insert Imvexxy?

Follow your doctor’s instructions carefully when using Imvexxy. This medication comes in the form of a small, soft gel capsule that needs to be inserted into your vagina. You can insert it either while standing up or lying down. Hold the capsule by its larger end between your thumb and finger. Position the capsule with the smaller end pointing upwards, and gently insert it about 2 inches (5 centimeters) into your vagina.

Is Imvexxy a suppository?

Imvexxy is a bio-identical soft gel vaginal insert, not a traditional suppository. It offers an applicator-free, mess-free administration experience without needing dose preparation. Imvexxy can be used at any time of day, which may improve patient compliance. It is the only ultra-low-dose vaginal estradiol available in both 4-mcg and 10-mcg doses.

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