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Empagliflozin / Linagliptin

Glyxambi Tablets

Glyxambi, an FDA-approved medication, is a combination of empagliflozin and linagliptin. These oral diabetes tablets are designed to control blood sugar levels effectively. Empagliflozin aids in removing glucose from your bloodstream via the kidneys, while linagliptin regulates insulin production post-meal. This medication is recommended for use alongside diet and exercise to enhance blood sugar management in adults with type 2 diabetes mellitus. Additionally, Glyxambi helps reduce the risk of death due to heart attack, stroke, or heart failure in adults with type 2 diabetes who also suffer from heart disease. So, if you want to buy Glyxambi to control blood sugar levels, you need a prescription from your doctor.

Product Overview

Glyxambi is an FDA-approved oral medication combining empagliflozin and linagliptin, designed to manage blood sugar levels in adults with type 2 diabetes. Empagliflozin works by removing glucose from the bloodstream through the kidneys, while linagliptin increases insulin production after meals. This drug is used alongside diet and exercise to improve glycemic control and reduce the risk of cardiovascular-related deaths in diabetic patients with heart disease. 

Glyxambi tablets come in strengths of 10 mg empagliflozin with 5 mg linagliptin and 25 mg empagliflozin with 5 mg linagliptin. The typical starting dose is 10 mg/5 mg taken orally once daily, which may be increased based on glycemic response. Common side effects of this medication include respiratory and urinary tract infections, joint pain, nausea, and hypoglycemia. It’s important not to exceed the prescribed dosage to avoid risks of overdose. 

Patients are advised to take the medication in the morning, with or without food, and to consult their doctor if they experience severe side effects or if their condition worsens. Glyxambi should be stored in a cool, dry place and kept out of reach of children. Interactions with diuretics, sulfonylureas, insulin, and alcohol can increase side effects, so patients should discuss their use with a doctor. Alternative medications include Steglatro, Victoza, and Jardiance, but changes should be made under medical supervision.

Uses of Glyxambi Tablets

  • To lower the risk of death and heart attack.
  • To manage blood sugar levels in type 2 diabetes patients.
  • To prevent nerve & sexual function issues, vision problems, and limb loss.

Benefits of Glyxambi Tablets

  • Increases insulin production
  • Removes some sugar through the urine
  • Decreases sugar production
  • Experience some weight loss

Side Effects of Glyxambi

Common side effects of Glyxambi may include:

  • Stuffy or runny nose  
  • Sore throat
  • Nausea
  • Upper respiratory infection
  • Urinary tract infection (UTI)
  • Joint Pain
  • Hypoglycemia (low blood sugar)

[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]

Glyxambi Dosage

Forms & Strengths

Glyxambi comes in tablet form & the following strengths:


  • 10 mg of empagliflozin with 5 mg linagliptin
  • 25 mg of empagliflozin with 5 mg linagliptin

Recommended Dosages

Dosage for Type 2 Diabetes Patients
  • Standard Dose: 10 mg/5 mg orally once daily in the morning, with or without food.
  • For Additional Glycemic Control: Your doctor may increase to 25 mg/5 mg once daily.
Patients with Hepatic Impairment
  • No dose adjustment is required.
Patients with Renal Impairment
  • eGFR ≥30 mL per min per 1.73 m²: No dose adjustment required.
  • eGFR <30 mL per min per 1.73 m² or end-stage renal disease (ESRD): Not recommended.

How to Take Glyxambi?

  • Take by mouth, with or without food, once daily in the morning.
  • Take regularly for best results, at the same time each day.
  • Do not crush or chew.
  • Inform your doctor if your condition does not improve or worsens (e.g., high or low blood sugar).

Missed Dose 

If you forget to take Glyxambi, take it as soon as you remember unless it’s already the next day. If it’s the next day, skip the missed dose and take your next Glyxambi dose as usual. Don’t take two doses at once; this can cause low blood sugar. Set an alarm or a reminder app on your phone to avoid missing doses of Glyxambi.


[Note: Do not take two doses of Glyxambi tablets at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]


It’s crucial not to exceed the prescribed dosage of Glyxambi. Taking more than the recommended amount of certain medications can result in side effects or overdose.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Glyxambi Work?

Glyxambi (empagliflozin/linagliptin) is a combination of two medications that work together to lower blood sugar. Empagliflozin is an SGLT2 inhibitor that helps your kidneys remove excess sugar through urine, while linagliptin is a DPP-4 inhibitor that helps your body produce more insulin and reduce sugar production. Together, they help manage blood sugar levels effectively.

Important Safety Precautions 

  • Inform your doctor if you are allergic to empagliflozin or linagliptin or have other allergies.
  • Inform your doctor if you are allergic to empagliflozin or linagliptin or have other allergies.
  • Share your medical history, especially kidney disease, dehydration, pancreatitis, alcohol use, gallstones, low blood pressure, heart failure, high cholesterol, yeast infections, blood vessel issues, nerve problems, foot sores, or amputation.
  • Avoid driving or using machinery if you experience blurred vision, dizziness, or drowsiness.
  • Limit alcohol as it can increase the risk of low blood sugar and high ketone levels.
  • Consult your doctor during stress, illness, or surgery, as your treatment plan may need adjustment.
  • Older adults may be more sensitive to side effects, particularly kidney issues, dehydration, dizziness, and low blood pressure.
  • Use during pregnancy only if necessary; discuss risks and benefits with your doctor.
  • Consult your doctor before breastfeeding, as it is unknown if the drug passes into breast milk.


  • Store Glyxambi tablets in a cool place (68°F to 77°F / 20°C to 25°C).
  • Keep them in a tightly closed container.
  • Avoid storing them in bathrooms or damp places.
  • Keep them out of reach of children & pets.

Glyxambi Interactions 

  • Diuretics (Water Pills): Using diuretics like chlorthalidone, furosemide (Lasix), spironolactone (Aldactone, Carospir), or hydrochlorothiazide (Microzide) with Glyxambi can increase side effects such as low blood pressure and dehydration.
  • Sulfonylureas (Diabetes Medications): Taking sulfonylureas like glyburide (Diabeta, Glynase), glimepiride (Amaryl), or glipizide (Glucotrol) with Glyxambi may raise the risk of low blood sugar.
  • Insulins: Using insulin medications such as insulin aspart (Novolog), premixed insulins (Humalog 50/50, Novolin 70/30), or insulin degludec (Tresiba) with Glyxambi might increase the likelihood of low blood sugar.
  • Alcohol: Heavy or regular alcohol use can exacerbate Glyxambi’s side effects, including an increased risk of ketoacidosis and dangerously low blood sugar levels. Discuss safe alcohol consumption with your doctor.

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Glyxambi Alternatives

  • Steglatro (ertugliflozin)
  • Victoza (liraglutide)
  • Repaglinide (meglitinides)
  • Onglyza (saxagliptin)
  • Ozempic (semaglutide)
  • Jardiance (empagliflozin)
  • Jentadueto (linagliptin and metformin)
  • Nesina (alogliptin)
  • Xigduo XR (dapagliflozin & extended-release metformin)
  • Byetta (exenatide)
  • Qtern (dapagliflozin and saxagliptin)
  • Rybelsus (semaglutide)
  • Janumet (sitagliptin phosphate and metformin hydrochloride)
  • Nateglinide (meglitinides)
  • Invokamet (canagliflozin and metformin)
  • Farxiga (dapagliflozin)
  • Tradjenta (linagliptin)
  • Steglujan (ertugliflozin and sitagliptin)
  • Januvia (sitagliptin)
  • Trulicity (dulaglutide)
  • Oseni (alogliptin and pioglitazone)

[Note: Your healthcare provider will choose which Glyxambi alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is Glyxambi bad for the kidneys?

Glyxambi has the potential to induce dehydration in certain individuals. Though infrequent, there have been isolated cases of individuals experiencing abrupt kidney damage attributed to dehydration from Glyxambi. Such kidney impairment necessitated hospital treatment.

What to avoid when taking empagliflozin?

Glyxambi, a medication used in the treatment of type 2 diabetes, has not been specifically linked to weight loss according to its clinical trial results. However, it’s important to note that Glyxambi can lead to certain side effects, such as dehydration and ketoacidosis. Both of these conditions could potentially result in temporary weight loss. If you are experiencing unexpected weight changes while using Glyxambi, it is essential to consult with your healthcare provider to ensure appropriate management and address any potentially serious health issues.

Can you stop taking Glyxambi?

If you experience persistent and severe stomach pain that radiates from your abdomen to your back, along with or without vomiting, please cease taking Glyxambi immediately and contact your healthcare provider. These symptoms could indicate pancreatitis.

What is the main side effect of empagliflozin?

This medication might heighten your chances of experiencing urinary tract infections (such as pyelonephritis or urosepsis). You can consult your doctor if you encounter symptoms like bladder discomfort, bloody or cloudy urine, challenging or painful urination, or lower back or side pain.

Our Guarantee

At Arctic Meds, we guarantee that you will find the most competitive prices for purchasing Glyxambi through our platform. As the best Canadian online pharmacy, we are committed to delivering only the highest quality products. Each order is fulfilled through a reputable and licensed Canada pharmacy online, ensuring that every product we ship meets stringent standards of quality and authenticity. Our reliable service ships your medications directly from Canada right to your doorstep. For seamless access to buy Glyxambi online from Canada at a low price, contact us.


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