Dalteparin
What is Fragmin?
As a low molecular weight (LMWH) medication, Fragmin is instrumental in preventing and treating conditions like deep vein thrombosis and pulmonary embolism. Given by subcutaneous injection plays a crucial role in patient care for those with cancer, heart conditions, or who are post-surgery. Available in multiple doses, this medication has many alternatives and interactions. For more affordable options, you can buy Fragmin online from Canada while ensuring both cost efficiency and optimal blood clot management.
Product Overview
Fragmin (dalteparin) is a low molecular weight heparin (LMWH) used to prevent and treat blood clots, encompassing deep vein thrombosis (DVT) & pulmonary embolism (PE). It is also used in patients undergoing surgery, cancer patients, and those with unstable angina or heart attacks. Fragmin works by inhibiting clotting factors, such as Factor Xa and thrombin, reducing the risk of clot formation and promoting clot breakdown.
Fragmin comes in various strengths and is available in prefilled syringes or vials. The dosage depends on the treated condition and is administered as a subcutaneous injection, generally in the abdomen or thigh. Common side effects of this medication include bleeding, bruising, and pain at the injection site.
It is essential to follow safety precautions, avoid certain medications like NSAIDs, and report unusual bleeding to your healthcare provider. Fragmin should be stored at room temperature and protected from light and moisture. Consult your doctor for guidance regarding dosage, administration, and interactions with other medications.
What Are the Uses of Fragmin?
- Prevention of deep vein thrombosis (DVT).
- Treatment of pulmonary embolism (PE).
- Prevention of blood clots in patients undergoing any type of surgery.
- Prevention of clotting in cancer patients.
- Blood clot prevention in patients with unstable angina or heart attacks.
- Prevention of clot formation in dialysis patients.
What Are the Benefits of Fragmin?
- Reduces the risk of blood clot formation.
- Helps prevent deep vein thrombosis (DVT) & pulmonary embolism (PE).
- Effective in preventing blood clots during and after surgery.
- Safe for use in cancer patients to prevent clotting.
- Supports heart health by preventing clot formation in angina or heart attack patients.
- It can be used in dialysis patients to prevent clotting.
What Are the Side Effects of Fragmin?
Common Fragmin side effects may include:
- Bleeding or bruising at the injection site
- Pain or irritation at the injection site
- Nausea
- Diarrhea
- Rash or itching
- Fever
- Elevated liver enzymes
- Low platelet count (thrombocytopenia)
- Dizziness
[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]
Fragmin Dosage
What Are the Forms & Strengths of Fragmin?
- Form: Injection (prefilled syringes or vials)
- Strengths:
-
- 2,500 IU/0.2 mL
- 5,000 IU/0.2 mL
- 7,500 IU/0.3 mL
- 10,000 IU/1 mL
- 12,500 IU/0.5 mL
- 15,000 IU/0.6 mL
- 18,000 IU/0.72 mL
What Are the Recommended Dosages of Fragmin?
Deep Vein Thrombosis (DVT) after surgery
- 2,500 IU once daily, starting before surgery and continuing for 5-10 days.
Treatment of Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE)
- 200 IU/kg of body weight once daily, up to a maximum of 18,000 IU per day.
Prevention of blood clots in cancer patients
- 200 IU/kg once daily for the first month, followed by 150 IU/kg once daily for the next 5 months.
Prevention of clotting in patients with unstable angina or heart attacks
- 120 IU/kg every 12 hours, up to 10,000 IU per dose.
How to Take Fragmin?
- Administer Fragmin as a subcutaneous injection (under the skin), usually in the abdomen or thigh.
- Wash your hands before handling the syringe.
- Rotate injection sites regularly to avoid skin irritation or bruising.
- Do not inject Fragmin directly into a vein or muscle.
- Ensure the syringe is filled correctly and free of air bubbles before injection.
- Pinch the skin gently and insert the needle at a 45-90-degree angle.
- Avoid rubbing the injection site after administering the dose.
- Follow your doctor’s prescribed schedule, and do not skip doses.
What to Do When You Miss a Dose of Fragmin?
If you miss a dose of Fragmin, take it at the earliest moment you remember. However, if it’s close to your next scheduled dose, skip the missed dose and take the next one at your regular time. Do not take two doses simultaneously to make up for the missed one.
[Note: Do not take two doses of Fragmin simultaneously to compensate for a missed dose. This can heighten your risk of experiencing side effects.]
What Happens When You Overdose on Fragmin?
Overdosing on Fragmin can lead to severe complications, primarily excessive bleeding. If you notice symptoms of overdose like unusual bruising, nosebleeds, blood in urine or stool, black or tarry stools, and prolonged bleeding from cuts. In severe cases, it may cause internal bleeding or hemorrhaging.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Fragmin Work?
Fragmin works by reducing the activity of key clotting factors in the blood, primarily targeting Factor Xa and thrombin. This reduction in clotting activity helps prevent dangerous clots from forming in the veins, which can lead to conditions like deep vein thrombosis (DVT) or pulmonary embolism (PE). It’s especially beneficial for patients undergoing surgeries, cancer treatments, or those at high risk for cardiovascular complications.
Important Safety Precautions
- Fragmin increases the risk of bleeding, particularly when used in combination with other medications like NSAIDs, antiplatelet drugs, or other anticoagulants.
- Avoid taking this medication if you are allergic to heparin or pork-based products.
- Practice cautiousness if you have a history of spinal deformities or recent spinal surgeries. Using Fragmin with epidural catheters may heighten the risk of bleeding or potential nerve damage.
- Always inform your medical professional if you are expecting or nursing before using Fragmin, as it could affect your treatment or dosage.
- Avoid strenuous activities or contact sports that could lead to injury or bruising while on Fragmin, as the medication increases your bleeding risk.
- Be cautious if you suffer from liver or kidney problems, as these conditions may alter how Fragmin works in your body.
- Fragmin can cause or worsen a low platelet count, increasing the risk of bleeding.
- Regularly monitor your blood platelet levels as directed by your healthcare provider.
- Avoid activities that may increase the risk of injury or bruising, as Fragmin increases the risk of bleeding.
How to Store Fragmin?
- Store Fragmin at room temperature, between 20°C to 25°C.
- Keep it in the original packaging to protect it from light.
- Protect this medication from direct light and moisture.
- Do not freeze the medication; discard it if frozen.
- Keep children and pets out of reach to prevent accidental use.
- Dispose of expired or unused Fragmin according to local regulations or return to your pharmacy.
- Do not use Fragmin past its expiration date.
What Medications Interact with Fragmin?
- Aspirin and NSAIDs
- Antiplatelet drugs
- Thrombolytics
- Anticoagulants
- Oral corticosteroids
- SSRIs and SNRIs
- Herbal supplements
[Note: This is not an exhaustive list of drug interactions of Fragmin. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
What Are the Fragmin Alternatives?
- Lovenox (enoxaparin)
- Innohep (tinzaparin)
- Heparin (heparin sodium)
- Xarelto (rivaroxaban)
- Eliquis (apixaban)
- Pradaxa (dabigatran)
- Savaysa (edoxaban)
- Coumadin or Jantoven (warfarin)
- Arixtra (fondaparinux)
- Argatroban (argatroban)
- Acova (bivalirudin)
- Plavix (clopidogrel)
- Brilinta (ticagrelor)
- Effient (prasugrel)
[Note: Your healthcare provider will choose which Fragmin alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Fragmin Cost & Coupons
The cost of Fragmin can differ depending on factors like health insurance coverage, and many Americans face high out-of-pocket costs if their insurance doesn’t fully cover it. To manage these expenses, some buy Fragmin online from Canada through services like Arctic Meds, offering a more affordable option for U.S. residents.
Frequently Asked Questions
Is Fragmin the same as heparin?
Fragmin is an LMWH that works similarly to heparin by thinning the blood to prevent clots. However, due to its different structure, Fragmin targets specific clotting proteins more effectively. When given as a subcutaneous injection, it is absorbed better, lasts longer, and requires fewer injections than regular heparin.
Can I take Fragmin with aspirin?
Avoid taking Fragmin alongside aspirin unless advised by your doctor, as it increases the risk of bleeding. However, for certain conditions like unstable angina, aspirin may be a part of the prescribed treatment plan. It is advisable that you always consult before starting or discontinuing any medications.
Does Fragmin need to be given at the same time each day?
If you inject Fragmin once daily, it can be administered at any time, but it’s essential to do it simultaneously each day. This ensures consistent medication levels in your body for optimal effectiveness.
Does Fragmin affect PT or INR?
No, Fragmin does not affect PT or INR, but it is commonly monitored for people on heparin or warfarin. Instead, Fragmin targets factor Xa, which can be monitored using anti-Xa levels. Monitoring is generally not required, except for high-risk individuals like children, pregnant women, or those with kidney issues. Anti-Xa levels help ensure proper dosing.
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