Estradiol/norethisterone
Buy Estalis Online
Estalis (estradiol/norethisterone) is a transdermal patch used to temporarily relieve menopausal symptoms such as hot flashes and night sweats and prevent bone thinning (osteoporosis) in postmenopausal women at serious risk of fractures. It delivers a combination of estrogen & progestin to provide balanced hormone therapy, especially for women with an intact uterus. The patch is applied twice weekly to the lower abdomen or buttocks, offering a convenient and consistent hormone absorption method.
Product Overview
Estalis is designed to provide hormone replacement therapy (HRT) for women experiencing menopausal symptoms or at high risk of osteoporosis. Estalis is particularly beneficial for women who still have a uterus, as it combines estradiol (a form of estrogen) with norethisterone (a synthetic progestin) to balance hormone levels & reduce the risk of endometrial hyperplasia. By delivering hormones directly through the skin, Estalis offers relief from hot flashes, night sweats & vaginal dryness while helping to prevent bone loss associated with osteoporosis. Available in different strengths, Estalis is applied twice weekly to the lower abdomen or buttocks. Following your healthcare provider’s instructions for proper application and dosage is crucial. Although Estalis is effective, it may cause side effects like breast tenderness, skin irritation, or mood changes. Routine monitoring and consultation with your healthcare provider are suggested to ensure safe and effective use.
Uses of Estalis
- Relief of menopausal symptoms
- Prevention of osteoporosis in postmenopausal women
- Management of estrogen deficiency symptoms
- Regulation of hormonal balance in women with an intact uterus
Benefits of Estalis
- Relieves menopausal symptoms
- Prevents osteoporosis
Side Effects of Estalis
Common Estalis side effects may include:
- Breast tenderness or pain
- Breast enlargement
- Irregular vaginal bleeding or spotting
- Abdominal cramps
- Skin irritation at the patch site
- Redness or rash
- Nausea
- Bloating
- Abdominal pain
- Mood swings
- Irritability
- Depression
- Including migraines in some cases
- Swelling in hands, feet, or ankles
- Weight changes
- Back pain
- Dizziness
- Fatigue
- Increased or decreased sex drive
[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]
Estalis Dosage
Forms & Strengths
- Form: Transdermal patch
- Strengths:
-
- 50 mcg estradiol / 140 mcg norethisterone acetate per day
- 50 mcg estradiol / 250 mcg norethisterone acetate per day
Recommended Dosages
- Replace this patch every 3 to 4 days.
- Different strengths are available; follow your healthcare provider’s instructions on the appropriate strength.
- Apply the patch consistently on the same days each week to maintain consistent hormone levels.
How to Take Estalis?
- Place the patch on a clean, dry, and non-irritated area of the lower abdomen or buttocks.
- Do not apply the patch to the breasts or near the waistline.
- To avoid skin irritation, change the application site with each new patch.
- Replace the patch twice weekly, typically every 3 to 4 days, on the same days each week.
- Press the Estalis patch firmly onto the skin for a minimum og 10 seconds to ensure it adheres well.
- Do not expose this patch to direct sunlight, heat sources, hot water, as this can affect its effectiveness.
- Use the patch as is; cutting it may alter the medication delivery.
- After use, fold the patch in half with the sticky sides together & dispose of it safely, out of reach of children and pets.
Missed Dose
If you miss a dose of Estalis, apply a new patch as soon as you remember. If it’s almost time for your following scheduled patch change, skip the missed dose and use the latest patch at your regular time. Do not apply two patches of Estalis to make up for the missed dose. Consult your medical professional for guidance if you’re unsure what to do.
[Note: Do not simultaneously take two doses of Estalis to compensate for a missed dose. This can increase your risk of experiencing side effects.]
Overdose
An overdose of Estalis may result in nausea, vomiting, breast tenderness, dizziness, or vaginal bleeding. While not typically life-threatening, it’s essential to seek medical attention if an overdose is suspected. Your healthcare provider can offer guidance and support to manage any symptoms that arise from the overdose.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Estalis Work?
Estalis is a transdermal patch that delivers a combination of estrogen (estradiol) and progestin (norethisterone) directly through the skin into the bloodstream. Estradiol is a form of estrogen that helps regulate various functions in the female body, including the menstrual cycle and reproductive system. As women approach menopause, their natural estrogen levels decline, leading to symptoms such as hot flashes, vaginal dryness, and bone loss. Estalis works by supplementing the body’s estrogen levels to alleviate these symptoms. The addition of norethisterone, a synthetic progestin, is important for women who still have their uterus, as it helps counteract the risk of endometrial hyperplasia (thickening of the uterine lining), which can occur with estrogen-only therapy. Together, these hormones work to provide relief from menopausal symptoms while also offering protection against certain risks associated with hormone therapy.
Important Safety Precautions
- Cardiovascular Risks: Increased risk of heart attack, stroke, and blood clots, especially in women who smoke or have a history of cardiovascular disease.
- Breast Cancer: Estalis may increase the risk of breast cancer; regular breast exams and mammograms are recommended.
- Endometrial Cancer: Increased risk of endometrial cancer in women with an intact uterus who use estrogen-only therapy.
- Liver Function: Use caution in women with liver disease; regular monitoring may be necessary.
- Blood Pressure: Monitor blood pressure regularly, as Estalis can cause hypertension.
- Thromboembolic Disorders: Contraindicated in women with a history of deep vein thrombosis, pulmonary embolism, or clotting disorders.
- Gallbladder Disease: Estalis may increase the risk of gallbladder disease; report any symptoms of gallstones or gallbladder issues to your healthcare provider.
- Migraine: Women with a history of migraines should use Estalis cautiously, as it may trigger or worsen migraine episodes.
- Diabetes: Monitor blood sugar levels closely, as Estalis may affect glucose tolerance.
- Pregnancy and Breastfeeding: Not recommended for use during pregnancy or breastfeeding; consult your healthcare provider if you become pregnant while using Estalis.
- Allergic Reactions: Watch for signs of allergic reactions, such as rash, itching, or swelling, and seek medical attention if these occur.
Storage
- Keep this patch away from direct heat sources and sunlight.
- Do not store it in the freezer or expose it to extreme cold.
- To protect the patches from moisture and light, keep them in their original packaging until ready to use.
- Store children and pets out of reach to prevent accidental use.
- Dispose of used patches properly, following the instructions provided, to avoid accidental exposure to others.
Estalis Interactions
- Ketoconazole
- Itraconazole
- Erythromycin
- Ritonavir
- Rifampin
- Carbamazepine
- Phenytoin
- St. John’s Wort
- Warfarin (may reduce effectiveness)
- It may increase corticosteroid effects and side effects
- Levothyroxine (may require dose adjustment)
- Insulin
- Oral antidiabetics (may require dose adjustment)
- It may reduce the effectiveness of blood pressure medications
- This may increase the risk of fluid retention
- Cyclosporine (may increase blood levels)
- May increase estrogen-related side effects
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions or supplements.]
Estalis Alternatives
- Climara Pro (estradiol/levonorgestrel)
- Combipatch (estradiol/norethindrone)
- Activella (estradiol/norethindrone acetate)
- Femhrt (ethinyl estradiol/norethindrone acetate)
- Prempro (conjugated estrogens/medroxyprogesterone acetate)
- Vivelle-Dot (estradiol)
- Climara (estradiol)
- Estraderm (estradiol)
- Premarin (conjugated estrogens)
- Estrace (estradiol)
- Menest (esterified estrogens)
- Provera (medroxyprogesterone acetate)
- Prometrium (micronized progesterone)
- Vagifem (estradiol vaginal tablets)
- Estring (estradiol vaginal ring)
- Premarin Vaginal Cream (conjugated estrogens)
- Brisdelle (paroxetine)
- Osphena (ospemifene)
- Replens (moisturizer)
[Note: Your healthcare provider will choose which Estalis alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
Where should I apply the Estalis patch?
Apply the Estalis patch to a smooth, hair-free area of the skin on the buttocks or abdomen, avoiding the waistline, as tight clothing may cause the patch to come off. Never apply the patch to or near the breasts. Replace the patch every 3 to 4 days.
When should you stop using estrogen patches?
People may choose to stop using estrogen patches after being on hormone replacement therapy for a specific duration, upon reaching a certain age, or when their menopausal symptoms begin to subside. Additionally, certain health conditions, like breast cancer, may necessitate discontinuing hormone replacement therapy.
What should I do if I miss my estrogen injection?
If you miss a dose of your estrogen injection, do not double up on doses. Apply the missed dose as soon as possible. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
What are the benefits of taking Estalis?
Estalis is used for the short-term relief of menopausal symptoms and can also help prevent bone thinning in women at high risk of fractures due to osteoporosis who cannot use other treatments. Estalis is specifically intended for women who still have a uterus.
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