Esomeprazole Magnesium
Esomeprazole Magnesium Tablets
Esomeprazole Magnesium is a proton pump inhibitor used to treat conditions like GERD, Zollinger-Ellison Syndrome, and stomach ulcers. It reduces stomach acid, alleviating symptoms like heartburn and preventing damage from acid erosion. Esomeprazole Magnesium is effective in healing erosive esophagitis and is part of regimens to eradicate H. pylori infections. Available in capsules and oral suspension, it offers a once-daily dosing schedule and is generally well-tolerated, making it a popular choice for long-term management of acid-related disorders.
Product Overview
Esomeprazole Magnesium is a key medication in managing gastrointestinal conditions. It plays a really crucial role in reducing the production of stomach acid. This medication is prescribed for gastroesophageal reflux disease (GERD) and Zollinger-Ellison Syndrome. It also works to treat and prevent stomach ulcers by blocking the acid pumps in the stomach lining. This action provides relief from persistent heartburn and protects the esophagus from acid damage, which can lead to erosive esophagitis—a condition in which Esomeprazole Magnesium can also help heal.
Additionally, Esomeprazole Magnesium is used in combination therapy for the eradication of H. pylori, a bacteria associated with ulcers and chronic gastritis. Its efficacy extends to preventing ulcers in patients who regularly use NSAIDs. The medication is available in various forms, including delayed-release capsules and oral suspension, ensuring flexible administration options.
It is especially favored for its once-daily dosing convenience and its effectiveness in maintaining long-lasting acid suppression, enhancing patient compliance and quality of life in managing acid-related health issues.
What Is Esomeprazole Magnesium Used For?
Esomeprazole magnesium manage various stomach-related conditions:
- Stomach Ulcers
- Zollinger-Ellison Syndrome
- H. pylori Infections
- GERD (Gastroesophageal Reflux Disease)
What Are the Benefits of Esomeprazole Magnesium?
- Effectively reduces stomach acid production by blocking acid pumps in the stomach lining.
- Treats heartburn and other symptoms of gastroesophageal reflux disease (GERD).
- Helps heal erosive esophagitis (damage to the esophagus from stomach acid).
- Can prevent and treat stomach ulcers, including those caused by NSAIDs.
- Used to treat conditions where the stomach makes too much acid, like Zollinger-Ellison syndrome.
- May be used as part of combination therapy to treat H. pylori infections.
- Provides long-lasting acid reduction with once-daily dosing.
- Available in multiple forms including capsules, tablets, and oral suspension.
- Generally well-tolerated with a low risk of side effects.
- Can provide relief from acid-related symptoms for up to 24 hours.
- May help prevent stomach damage in patients who need to take NSAIDs long-term.
What Are the Side Effects of Esomeprazole Magnesium?
Common Esomeprazole Magnesium side effects may include:
- Passing gas (flatulence)
- Stomach pain
- Headache
- Constipation
- Diarrhea
- Dry mouth
- Nausea
[Note: This list is not exhaustive, if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]
What Are the Forms & Strengths of Esomeprazole Magnesium?
Esomeprazole Magnesium is available in oral delayed-release tablet and has two strengths:
- 20 mg
- 40 mg
What Is the Typical Dosage of Esomeprazole Magnesium?
Dosage of Esomeprazole Magnesium for Stomach Ulcer
- Adults (18 and older): 20 mg or 40 mg once daily for up to 6 months.
- Children (0 to 17 years): Not studied.
Dosage of Esomeprazole Magnesium for Zollinger-Ellison Syndrome
- Adults (18 and older): Typical dosage is 40 mg twice daily, with possible increases up to 240 mg per day if needed.
- Children (0 to 17 years): Not studied for this age group.
Dosage of Esomeprazole Magnesium for H. pylori Infection
- Adults (18 and older): 40 mg once daily for 10 days, combined with amoxicillin and clarithromycin.
- Children (0 to 17 years): Not studied.
Dosage of Esomeprazole Magnesium for GERD and Erosive Esophagitis
- Adults (18 and older):
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- Healing Erosive Esophagitis: 20 mg or 40 mg once daily for 4 to 8 weeks. May repeat treatment for another 4 to 8 weeks if symptoms persist.
- Maintenance of Healed Erosive Esophagitis: 20 mg once daily.
-
- Symptomatic GERD Treatment: 20 mg once daily for 4 weeks.
- Children (12 to 17 years):
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- Healing Erosive Esophagitis: 20 mg or 40 mg once daily for 4 to 8 weeks.
- Symptomatic GERD: 20 mg once daily for 4 weeks.
-
- Children (1 to 11 years):
-
-
- Symptomatic GERD: 10 mg once daily for 8 weeks.
-
- Erosive Esophagitis:
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-
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- Under 44 lb (20 kg): 10 mg once daily for 8 weeks.
- 44 lb (20 kg) and over: 10 mg or 20 mg once daily for 8 weeks.
-
-
- Infants (1 to 11 months):
- Erosive Esophagitis Due to GERD:
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-
- 6.6–11 lb (3–5 kg): 2.5 mg once daily for up to 6 weeks.
- 11–16.5 lb (>5–7.5 kg): 5 mg once daily for up to 6 weeks.
- 16.5–26.5 lb (>7.5–12 kg): 10 mg once daily for up to 6 weeks.
-
- Infants (younger than 1 month): Not studied.
Special Dosage Considerations
- Severe Liver Problems: Maximum recommended dose should not exceed 20 mg per day.
How to Take Esomeprazole Magnesium?
-
- Timing with Meals: Take Esomeprazole Magnesium at least one hour before meals to enhance absorption.
- Follow Doctor’s Instructions: Administer the medication as directed by your healthcare provider to maximize effectiveness.
- Consumption of Capsules:
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- Swallow capsules whole; do not chew or crush.
- If it is difficult to swallow, open the capsule and sprinkle contents onto a spoonful of applesauce. Consume immediately without chewing granules. Do not store for later use.
- Adherence to Prescription: Strictly adhere to your doctor’s prescribed dosage and schedule to minimize side effects and ensure effectiveness.
What to Do When You Miss a Dose of Esomeprazole?
If you miss a dose of Esomeprazole, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule.
[Note: Do not take two doses of Esomeprazole Magnesium at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]
What Happens When You Overdose on Esomeprazole?
Symptoms of an overdose may include confusion, blurred vision, nausea, fast heartbeat, drowsiness, sweating, flushing, dry mouth, and headache. If you overdose, contact your doctor or seek emergency assistance immediately.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Esomeprazole Magnesium Work?
Esomeprazole Magnesium is a proton pump inhibitor (PPI) that reduces stomach acid production by blocking the proton pump in the stomach cells.
What Are the Important Safety Precautions of Esomeprazole?
- Kidney Damage: Monitor for back pain or changes in urination, which may indicate kidney issues.
- Severe Diarrhea: Contact your doctor immediately if you experience severe diarrhea, as it may indicate Clostridium difficile infection.
- Long-term Use Risks: Increases risk of osteoporosis-related fractures, stomach lining inflammation, and reductions in magnesium and vitamin B-12 levels.
- Autoimmune Triggers: May trigger autoimmune diseases such as CLE and SLE; watch for symptoms like skin rashes and fever.
- Fundic Gland Polyps: Long-term use may cause benign growths in the stomach; limit duration of use.
- Allergic Reactions: Seek immediate help for symptoms like difficulty breathing or facial swelling.
- Liver Health: Those with severe liver problems should use caution as impaired processing can increase drug levels.
- Nutrient Deficiency: Long-term use may lower magnesium and vitamin B-12 levels; supplementation and monitoring may be required.
- Bone Health: Increased risk of fractures with long-term use; monitor bone health.
- Diagnostic Interference: May affect diagnostic tests for neuroendocrine tumors.
- Pregnancy and Breastfeeding: Discuss potential risks and benefits; may pass into breast milk.
- Use in Children: Not studied in infants under one month old.
How Do You Store Esomeprazole Magnesium?
- Keep at room temperature, between 59°F and 86°F (15°C and 30°C).
- Store away from direct light to maintain medication quality.
- Keep the container tightly closed to protect from moisture and air.
- Avoid storing in damp or humid areas like bathrooms to prevent degradation.
What Drugs Interact with Esomeprazole Magnesium?
- Digoxin
- Tacrolimus
- Warfarin
- Clopidogrel
- Methotrexate
- Saquinavir
- Cilostazol
- Diazepam
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions or supplements.]
What Are the Alternatives to Esomeprazole Magnesium?
- Gaviscon (aluminum hydroxide-magnesium carbonate)
- Nizatidine
- Prevacid (lansoprazole)
- Tums (calcium carbonate)
- Zegerid (omeprazole/sodium bicarbonate)
- Aciphex (rabeprazole)
- Protonix (pantoprazole)
- Rolaids Extra Strength (calcium carbonate-magnesium hydroxide)
- Omeprazole
- Nexium (Esomeprazole)
- Tagamet HB 200 (cimetidine)
- Pepcid AC Maximum Strength (famotidine)
- Dexilant (dexlansoprazole)
- Mylanta Maximum Strength (aluminum hydroxide-magnesium hydroxide-simethicone)
- Zantac 360 Maximum Strength (ranitidine)
- Carafate (sucralfate)
[Note: Your healthcare provider will choose which Esomeprazole Magnesium alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Esomeprazole Magnesium Cost & Coupons
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Frequently Asked Questions
How long does it take for Esomeprazole magnesium to work?
Esomeprazole may show initial improvements within a day, but typically, it takes about three to four days to experience significant relief. Continue taking it as prescribed to ensure complete healing and prevent future issues.
What is the best time of day to take Esomeprazole magnesium?
Take Esomeprazole magnesium about an hour before meals for optimal absorption. If taking antibiotics like amoxicillin or clarithromycin for an H. pylori infection, take them simultaneously to improve effectiveness.
Do you take Esomeprazole with water?
Take Esomeprazole with a full glass of water (8 ounces). Do not chew or crush the capsule; swallow it whole. It’s best taken at least an hour before meals.
When is the best time to take Esomeprazole at night?
If needed at night, take Esomeprazole one to two hours before bedtime to help control acid reflux more effectively overnight.
What is the proper way to take Esomeprazole?
Typically, take Esomeprazole once daily in the morning, with or without food. If prescribed twice a day, take the second dose in the evening. Always swallow tablets or capsules whole with water.
Can I lie down after taking Esomeprazole?
Avoid lying down immediately after taking Esomeprazole. For morning doses, take it before breakfast with water. If taking it in the evening, do so well before bedtime to allow the medication to work effectively while upright.
Can I stop taking Esomeprazole suddenly?
Do not stop taking Esomeprazole suddenly, especially after long-term use, as it may cause increased stomach acid production and worsen symptoms. Consult your doctor to gradually decrease the dose to minimize this risk.
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