Desvenlafaxine Succinate

Desvenlafaxine

Desvenlafaxine is an SNRI antidepressant used to treat major depressive disorder. It enhances mood, energy, and well-being by increasing serotonin and norepinephrine levels in the brain. Desvenlafaxine offers once-daily dosing and is available in extended-release tablets, which helps maintain steady medication levels. Generally well-tolerated, it can be effective for patients unresponsive to other antidepressants and has minimal drug interactions. Desvenlafaxine also offers potential benefits for menopausal women by reducing hot flashes.

Product Overview

Desvenlafaxine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) designed to treat major depressive disorder by adjusting chemical imbalances in the brain. It helps alleviate depression symptoms such as low mood, lack of energy, and reduced interest in daily activities. This medication is recognized for its quick onset of action, generally resulting in mood improvements within a few weeks of starting treatment.

Desvenlafaxine is formulated as extended-release tablets in 25 mg, 50 mg, and 100 mg dosages, facilitating consistent drug levels in the bloodstream with once-daily dosing. Side effects include nausea, dizziness, dry mouth, and possible sexual dysfunction, but these are typically manageable. 

Desvenlafaxine is noted for its low likelihood of drug interactions, making it a safer choice for patients taking multiple medications. Additionally, it’s often prescribed for menopausal women to manage hot flashes, demonstrating its versatility beyond depression treatment.

What Is Desvenlafaxine Used For?

• Major depression

What Are the Benefits of Desvenlafaxine?

• Effectively treats major depressive disorder (MDD) by balancing brain chemicals.
• Helps improve mood, energy levels, and overall sense of well-being.
• May reduce anxiety symptoms that often accompany depression.
• Can help restore interest in daily activities and normal sleep patterns.
• Generally well-tolerated, with predictable side effects.
• Convenient once-daily dosing schedule.
• May help reduce hot flashes in menopausal women (off-label use).
• Does not require extensive dose titration when starting treatment.
• Available in extended-release formulation for consistent drug levels.
• Can be effective in patients who haven’t responded well to other antidepressants.
• Minimal drug interactions compared to some other antidepressants.
• May help improve physical symptoms associated with depression, such as pain or fatigue.

What Are the Side Effects of Desvenlafaxine?

Common Desvenlafaxine side effects may include:

• Blurry Vision
• Trouble Sleeping
• Decreased Appetite
• Feeling Jittery
• Decreased Sex Drive
• Vomiting
• Dry Mouth
• Problems with Sexual Function
• Dizziness
• Nausea
• Tiredness
• Constipation

[Note: This list is not exhaustive, if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]

What Are the Forms & Strengths of Desvenlafaxine?

Desvenlafaxine Succinate comes in the form of oral extended-release tablet and these three strengths:

• 25 mg
• 50 mg
• 100 mg

What Is the Typical Dosage of Desvenlafaxine?

Dosage of Desvenlafaxine Succinate for Depression

• Adult Dosage (ages 18 to 64 years):

• • • Starting Dosage: 50 mg once daily.
    • Maintenance Dosage: Typically remains at 50 mg once daily.
    • Maximum Dosage: Can be increased up to 400 mg per day based on individual response and tolerance.
  • Child Dosage (ages 0 to 17 years): Desvenlafaxine is not recommended for children under 18 as its safety and efficacy have not been established.
  • Senior Dosage (ages 65 years and older): A reduced dose or altered dosing schedule may be necessary to minimize risk of prolonged drug presence and increased side effects.

• Dosage Adjustments for Special Conditions:

• • Kidney Disease: Dosage adjustments may be required based on kidney function, with potential dosages being 50 mg daily, 25 mg daily, or 50 mg every other day.
  • Liver Disease: Maximum dosage may be limited to 100 mg per day, starting with the standard dose of 50 mg daily.

How to Take Desvenlafaxine?

• Swallow the Desvenlafaxine tablet whole without crushing, splitting, or chewing to ensure it works correctly.
• If you have difficulty swallowing tablets, seek advice from your doctor or look for tips on easier methods to swallow pills.
• You can take Desvenlafaxine with or without food, whichever suits your routine better.
• Take your medication at the same time every day to keep a stable level in your body for effectiveness.

What to Do When You Miss a Dose of Desvenlafaxine? 

If you miss a dose of Desvenlafaxine, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

[Note: Do not take two doses of Desvenlafaxine at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]

What Happens When You Overdose on Desvenlafaxine?

Symptoms of a Desvenlafaxine overdose include agitation, hallucinations, seizures, and nausea. If you overdose, immediately contact your doctor or local poison control center. For severe symptoms, call 911 or go to the nearest emergency room.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Desvenlafaxine Work?

Desvenlafaxine is an SNRI antidepressant that helps increase the levels of serotonin and norepinephrine in the brain by blocking their reuptake. This action helps improve mood and emotional well-being.

What Are the Important Safety Precautions of Desvenlafaxine?

• Increased Blood Pressure: Monitor your blood pressure regularly. Contact your doctor if it rises significantly.
• Serotonin Syndrome: Symptoms include agitation, hallucinations, seizures, and nausea. Seek immediate medical help if they occur.
• Allergic Reactions: Severe reactions like difficulty breathing or throat swelling require emergency assistance.
• Bleeding Risk: Increased risk of bleeding, especially if taking other blood-thinning medications.
• Withdrawal Symptoms: Do not stop abruptly. Withdrawal may cause dizziness, headaches, and irritability.
• Suicidal Thoughts: Increased risk, especially in young people under 24 during the first four weeks. Report any suicidal thoughts immediately.
• Use in Children: Not approved for under 18 years old.
• Health Conditions: Inform your doctor if you have high blood pressure, glaucoma, seizure disorders, kidney or liver problems.
• Pregnancy and Breastfeeding: Discuss risks and benefits with your doctor if pregnant or breastfeeding.
• Elderly Use: May require lower doses due to slower drug processing.

How Do You Store Desvenlafaxine?

• Store at room temperature, between 68°F and 77°F (20°C and 25°C).
• Keep the medication away from light and moisture to preserve its effectiveness.

What Drugs Interact with Desvenlafaxine?

• NSAIDs
• Other antidepressants
• Anticoagulants
• Serotonergic drugs
• Monoamine Oxidase Inhibitors (MAOIs)
• Aspirin
• Diuretics (water pills)

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions or supplements.]

What Are the Alternatives to Desvenlafaxine?

• Viibryd (vilazodone)
• Tricyclic Antidepressants
• Wellbutrin SR (bupropion)
• Selegiline
• Pristiq (Desvenlafaxine succinate)
• Trimipramine Maleate
• Doxepin
• Prozac (fluoxetine)
• Forfivo XL (bupropion)
• Effexor XR (venlafaxine)
• Cymbalta (duloxetine)
• Trintellix (vortioxetine)
• Remeron (mirtazapine)
• Phenelzine
• Celexa (citalopram)
• Zoloft (sertraline)
• Fetzima (levomilnacipran)
• Amitriptyline

[Note: Your healthcare provider will choose which Desvenlafaxine alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]

Desvenlafaxine Cost & Coupons

Desvenlafaxine Succinate, a key antidepressant, can be prohibitively expensive in the U.S. At Arctic Meds, we help by offering the chance to buy Desvenlafaxine Succinate online for depression treatment at reduced prices. American residents can enjoy an additional 10% off when they buy Desvenlafaxine online with coupon code “ARCTIC10” on their first order. Maximize your savings by participating in our referral program, potentially saving up to $200 on your healthcare needs.

Frequently Asked Questions

Is Desvenlafaxine a strong antidepressant?

Yes, Desvenlafaxine is an effective antidepressant, particularly at daily doses of 50 mg to 100 mg. It is generally well-tolerated and safe within these dosage limits and has also shown benefits for treating chronic pain in some cases.

Do you gain weight on Desvenlafaxine?

Desvenlafaxine typically does not cause significant weight changes. Most people do not notice any weight gain or loss, regardless of how long they take the medication.

Is it better to take Desvenlafaxine in the morning or at night?

Desvenlafaxine can be taken either in the morning or at night. It’s important to take it at the same time every day to keep its effectiveness consistent.

What happens if you just stop taking Desvenlafaxine?

Abruptly stopping Desvenlafaxine can cause withdrawal symptoms such as dizziness, shaking, confusion, tingling sensations, and headaches. It is essential to taper off the medication as directed by your doctor to avoid these issues.

Is 50 mg of Desvenlafaxine a lot?

A 50 mg dose of Desvenlafaxine is the standard starting and ongoing therapeutic dose. It is effective for most individuals and should be taken daily, either with food or on an empty stomach.

Is Desvenlafaxine safe long term?

Desvenlafaxine can be safe for long-term use when taken as directed by your healthcare provider. However, suddenly stopping the medication without consulting your doctor can lead to withdrawal symptoms.

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