Dapagliflozin 

Buy Dapagliflozin Online

Dapagliflozin is an FDA-approved medication used to treat type 2 diabetes, heart failure, and chronic kidney disease. It works by preventing glucose reabsorption in the kidneys, which helps lower blood sugar levels. The starting dose is typically 5 mg daily, which can be increased to 10 mg depending on patient tolerance and medical need. It should be taken consistently at the same time each day, with or without food. Patients must follow safety guidelines carefully, as Dapagliflozin can have serious risks such as ketoacidosis and dehydration. So, if you want to buy Dapagliflozin to treat type 2 diabetes, heart failure, and chronic kidney disease, you need to get a valid prescription from your doctor.

Product Overview 

Dapagliflozin is an FDA-approved medication used to treat type 2 diabetes, heart failure with reduced ejection fraction, and chronic kidney disease. It inhibits the sodium-glucose cotransporter 2 (SGLT2) in the kidneys, preventing glucose reabsorption into the bloodstream and promoting glucose excretion through urine. This helps lower blood sugar levels, aids in weight loss, and reduces blood pressure, addressing essential aspects of type 2 diabetes management.

Available in tablet form, Dapagliflozin comes in 5 mg and 10 mg strengths. The starting dose for type 2 diabetes is typically 5 mg once daily, which may be increased to 10 mg for better glycemic control if well-tolerated. For heart failure and chronic kidney disease, the recommended dose is 10 mg once daily. Dapagliflozin is not suitable for patients with type 1 diabetes or those on dialysis. Its use requires careful monitoring of kidney function.

Dapagliflozin carries significant risks, including ketoacidosis, urinary tract infections, dehydration, and potentially severe conditions like Fournier’s Gangrene. Patients should follow dosing instructions carefully, avoid doubling up on missed doses, and store the medication at room temperature, away from moisture and light. 

Uses of Dapagliflozin 

This medication is used in 

• Type 2 Diabetes Management
• Chronic Kidney Disease Treatment
• Heart Failure Treatment

Benefits of Dapagliflozin 

• Weight Loss
• Blood Pressure Reduction
• Improved Glycemic Control
• Cardiovascular Health
• Kidney Protection

Side Effects of Dapagliflozin

Common side effects of Dapagliflozin may include:

• Increased urination
• Nausea
• Thirst
• Genital yeast infections
• Back pain
• Urinary tract infections (UTIs)

[Note: This list is not exhaustive, if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]

Dapagliflozin Dosage

Forms & Strengths

Dapagliflozin is available in tablet form with two dosage options 

• 5 mg 
• 10 mg

Recommended Dosages

Type 2 Diabetes

• Start with 5 mg orally once daily.
• Increase to 10 mg daily for better glycemic control if well-tolerated.
• Maximum dose: 10 mg/day.
• Ensure renal function is adequate (eGFR > 45 mL/min/1.73 m²) for effectiveness.
• Consider reducing insulin doses to lower the risk of hypoglycemia when used with insulin or insulin secretagogues.

Heart Failure with Reduced Ejection Fraction

• Recommended dose: 10 mg orally once daily.
• Correct any volume depletion before starting therapy.
• Not suitable for patients with type 1 diabetes.

Chronic Kidney Disease

• Recommended dose: 10 mg orally once daily.
• Correct any volume depletion before starting therapy.
• Avoid in patients with polycystic kidney disease or recent immunosuppressive therapy.
• Not suitable for patients with type 1 diabetes.

Renal Dose Adjustments

• For type 2 diabetes control:
  • eGFR ≥ 45 mL/min/1.73 m²: No adjustment needed.
  • eGFR < 45 mL/min/1.73 m²: Not recommended.
• For other indications:
  • eGFR > 25 mL/min/1.73 m²: No adjustment needed.
  • eGFR < 25 mL/min/1.73 m²: Not recommended for initiation, but existing patients may continue 10 mg/day.

Liver Dose Adjustments

• Mild to moderate impairment: No adjustment needed.
• Severe impairment: Use caution; safety and efficacy are not well-studied.

How to Take Dapagliflozin? 

• Take Dapagliflozin exactly as prescribed.
• Do not change the dose or frequency without consulting your doctor.
• Take with or without food.
• Swallow the tablet whole with water; do not crush, chew, or break it.
• Take at the same time each day.
• Regularly monitor your blood sugar levels.
• Drink plenty of fluids to stay hydrated, especially with frequent urination.

Missed Dose 

If you miss a dose of Dapagliflozin, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and stick to your regular schedule. Do not take two doses at once.

[Note: Do not take two doses of Dapagliflozin at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]

Overdose

An overdose of Dapagliflozin can cause serious health issues. Overdose symptoms of this medication may include dehydration, frequent urination, low blood pressure, or electrolyte imbalances. Treat any Dapagliflozin overdose as a medical emergency.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Dapagliflozin Work?

Dapagliflozin works by blocking the sodium-glucose cotransporter 2 (SGLT2) in the kidneys. This transporter usually reabsorbs glucose into the bloodstream. By inhibiting SGLT2, Dapagliflozin stops glucose reabsorption, causing excess glucose to be excreted through urine. This process helps lower blood sugar levels in people with type 2 diabetes and can also promote weight loss and reduce blood pressure.

Important Safety Precautions

• Tell your healthcare provider if you have type 1 diabetes or have had diabetic ketoacidosis.
• Let your healthcare provider know if you have liver problems.
• Mention any history of urinary tract infections or urination difficulties.
• If you’re having surgery, discuss with your doctor when to stop and restart Dapagliflozin.
• Notify your healthcare provider if you’re eating fewer calories or if your diet changes.
• Share any pancreas-related issues, like pancreatitis or pancreatic surgery, with your healthcare provider.
• Inform your healthcare provider if you frequently drink alcohol or binge drink.

Storage

• Store Dapagliflozin at room temperature (68°F to 77°F or 20°C to 25°C).
• Keep it in its original container, tightly closed.
• Keep out of reach of children.
• Protect from moisture and light; don’t store in bathrooms or damp areas.
• Avoid extreme temperatures and direct sunlight.
• Check the packaging for any specific storage instructions from the manufacturer.

Dapagliflozin Interactions

• Antidepressants
• Cholesterol-lowering drugs
• Insulin
• Pain relievers (paracetamol)
• Aspirin
• Metformin
• Blood pressure medications
• Anticoagulants
• Vitamins (B12, C, D3)
• Fish oil
• Heart medications (Lantus, Lipitor)
• Diabetes medications (Janumet, Januvia, Jardiance, Ozempic, Trulicity, Victoza)
• Liver dysfunction
• Renal dysfunction
• Hypotension
• Infections

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Dapagliflozin Alternatives

• Jardiance (empagliflozin)
• Zynquista (sotagliflozin)
• Remo, Remozen (remogliflozin)
• Invokana (canagliflozin)
• Steglatro (ertugliflozin)

[Note: Your healthcare provider will choose which Dapagliflozin alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is Dapagliflozin good for the heart?

Dapagliflozin has shown significant benefits for individuals with heart failure. This medication works by decreasing the workload on the heart, which helps it pump blood more efficiently throughout the body. By reducing the strain on the heart, Dapagliflozin can alleviate common symptoms of heart failure, including shortness of breath, fatigue, and swelling in the lower extremities. Moreover, it plays a crucial role in lowering the risk of the heart becoming further weakened, thereby enhancing overall heart function and potentially improving the quality of life for those affected by heart failure.

Does Dapagliflozin affect the liver?

Dapagliflozin, a medication primarily used to manage blood glucose levels, has shown significant benefits for liver health. It has been demonstrated to effectively reduce fat accumulation in both the liver and pancreas, which is particularly beneficial for individuals with non-alcoholic fatty liver disease (NAFLD). By decreasing hepatic and pancreatic fat content, Dapagliflozin not only aids in better glucose control but also offers a promising therapeutic option for improving liver function and mitigating the effects of NAFLD.

Does Dapagliflozin lower cholesterol?

Dapagliflozin has been shown to positively influence cholesterol levels in patients with type 2 diabetes. Specifically, it reduces the levels of small, dense, low-density lipoprotein-cholesterol (sdLDL-C), which is a particularly harmful form of cholesterol associated with increased cardiovascular risk. Additionally, Dapagliflozin increases levels of high-density lipoprotein 2-cholesterol (HDL2-C), a beneficial type of cholesterol that helps protect against heart disease.

Is Dapagliflozin safe?

Yes, Dapagliflozin is generally considered safe for most patients, but it does come with some safety concerns. This medication not only aids in lowering blood sugar levels in individuals with type 2 diabetes, but it also provides additional clinical benefits such as promoting weight loss and reducing blood pressure. However, it is important to be aware that Dapagliflozin can increase the risk of urinary and genital tract infections. These infections are typically mild to moderate in severity and can often be managed with appropriate medical treatment. Patients should discuss potential risks and benefits with their healthcare provider to determine if Dapagliflozin is the right choice for their treatment plan.

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