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Creon capsules, also known by their generic name pancrelipase, help your body digest food better. This medication contains a combination of 3 crucial enzymes – lipase, protease, and amylase. These enzymes break down proteins, fats, and sugars in the food you eat. Usually, your pancreas makes these enzymes, but some people can’t produce enough due to conditions like cystic fibrosis or pancreas issues. Moreover, this medication is available in five different strengths, but your doctor will determine the appropriate dosages based on your body’s requirements. This FDA-approved delayed-release oral capsule alleviates stomach pain and enhances stool consistency when taken with particular meals. You can buy Creon online from a Canadian pharmacy when you have a valid prescription provided by your doctor. 

Product Overview

Creon is a pharmaceutical remedy designed to facilitate the digestive process within the body, including three essential enzymes: lipase, protease, and amylase. These enzymes play a crucial role in the breakdown of proteins, fats, and sugars, thereby assisting individuals who experience insufficient enzyme production due to conditions such as cystic fibrosis or pancreas-related issues. This medication, approved by the FDA, is obtainable in varying strengths, with the appropriate dosage determined by your healthcare provider based on your specific requirements.

Primarily used for treating pancreatic enzyme deficiency, Creon enhances stool consistency and mitigates stomach pain. The recommended dosage is contingent upon the nature of the condition, including conditions like exocrine pancreatic insufficiency in both adults and children, cystic fibrosis, and pancreatitis. Administering Creon involves either swallowing the capsule with water or, if necessary, dispersing its contents onto acidic food. Functioning within the small intestine, Creon releases enzymes to facilitate digestion, thereby enhancing nutrient absorption.

Like many medications, Creon also has common side effects that include stomach discomfort, vomiting, and alterations in bowel movements. There are also some of Creon’s severe side effects, which could include skin rash, bowel obstruction, and joint pain. You must inform your healthcare provider of any allergies, medical history, and diabetes-related concerns. Creon may interact with specific medications, antacids, supplements, and herbs. Additionally, Creon typically does not induce weight loss but may contribute to weight gain. To assess its efficacy, using a treatment tracker is recommended, and any unusual symptoms should prompt consultation with your healthcare provider.   

Uses of Creon

  • Treats pancreatic enzyme deficiency.
  • Improves stool consistency & stomach pain.

How to Use Creon?


Creon capsules are taken orally and are available in the strengths as follows:

Creon 3,000

  • 3,000 lipase units
  • 9,500 protease units
  • 15,000 amylase units

Creon 6,000

  • 6,000 lipase units
  • 19,000 protease units
  • 30,000 amylase units

Creon 12,000

  • 12,000 lipase units
  • 38,000 protease units
  • 60,000 amylase units

Creon 24,000

  • 24,000 lipase units
  • 76,000 protease units
  • 120,000 amylase units

Creon 36,000

  • 36,000 lipase units
  • 114,000 protease units
  • 180,000 amylase units

Recommended Dosage for Different Patients

The amount of Creon medicine a person needs depends on their weight, diet, and how well they respond to the medicine. Here are the suggested doses for various situations:

Exocrine Pancreatic Insufficiency (EPI) in Adults:

  • The starting dose depends on body weight, diet, and response to Creon.

EPI Caused by Cystic Fibrosis:

  • Start with 500 lipase units per kilogram of body weight with each complete meal.
  • The maximum dose is 2,500 lipase units per kilogram with each full meal or 10,000 lipase units per kilogram per day.
  • Adjust based on fat consumption, but not more than 4,000 lipase units per gram of fat per day.

EPI Caused by Pancreatitis, Pancreatectomy, or Other Conditions:

  • The dosage depends on the severity, diet fat content, and the presence of steatorrhea.

For Birth to Children Under Age 12 Months:

  • 3,000 lipase units per breastfeeding session or for every 120 milliliters of formula consumed.
  • Do not mix Creon directly into breast milk or formula.

Children Ages 12 Months to 4 Years:

  • 1,000 lipase units per kilogram of body weight per meal.
  • The maximum dose is 2,500 lipase units per kilogram of body weight per day or 10,000 lipase units per kilogram per day.

Children Ages 4 Years and Older:

  • Exact dosage as adults; follow the recommendations for adults.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

To take Creon capsules:

  • Swallow the capsule with a full glass of water. Don’t keep it in your mouth.
  • If you find it hard to swallow, open the capsule and sprinkle the contents on acidic food like applesauce.
  • Drink enough liquid to ensure you’ve swallowed the medicine entirely.
  • Don’t save the mixture for later use.
  • Drink plenty of water every day.
  • Don’t go over 10,000 lipase units per kilogram of your body weight in a day unless your doctor tells you to.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust your doses of Creon as needed over time.]

How Does Creon Work?

When you take Creon with your meals, it opens in your small intestine, releasing enzymes to help digest the food. This makes it easier for your body to absorb nutrients, providing energy and promoting growth.

Important Safety Information

Side Effects

Common side effects of Creon include

  • Stomach discomfort, including pain and gas.
  • Vomiting.
  • Changes in bowel movements (like diarrhea or abnormal frequency).
  • Itching around the rectal area.
  • Headaches or feelings of dizziness.
  • Respiratory symptoms like cough, stuffy or runny nose, or sore throat.
  • Fluctuations in blood sugar levels.

Serious side effects of Creon include

  • Skin Rash or Hives
  • Bowel Blockage
  • Blood in the Urine
  • Joint Pain and Swelling of Feet or Lower Legs
  • Difficulty with Swallowing
  • Fast Heartbeat
  • Redness of the Skin
  • Puffiness or Swelling Around the Eyes, Face, Lips, or Tongue
  • Unusual Tiredness or Weakness
  • Severe Stomach Pain

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


Risk of Colon Scarring (Fibrosing Colonopathy): Using pancrelipase (Creon) in high doses or for a prolonged period may lead to serious colon scarring, especially in children with cystic fibrosis. Only take pancrelipase (Creon) as your healthcare provider prescribes, and do not exceed the recommended dosage or duration.

Mouth Irritation Warning: Swallow the whole pancrelipase (Creon) without chewing, crushing, or holding it in your mouth. Immediately swallow with water or juice to ensure nothing remains in your mouth. Otherwise, it will irritate your mouth because of its taste.

Risk of High Uric Acid Levels: Pancrelipase (Creon) may increase uric acid levels, potentially raising the risk of gout. Consult your healthcare provider if you have gout, kidney issues, or elevated uric acid levels.


Allergies and Ingredients: Before you start taking pancrelipase, it’s crucial to inform your pharmacist or doctor if you have any allergies, especially to pancrelipase itself or pork protein. This medication might also have other inactive ingredients that could trigger allergic reactions and other issues. For more information, please consult your pharmacist.

Medical History: Your doctor needs to know about your medical history before you use pancrelipase. Specifically, inform them if you have had:

  • Acute pancreatitis is a sudden & severe swelling of the pancreas.
  • A sudden increase in the severity of a long-term pancreatic disease.
  • Kidney disease.
  • Gout.
  • Blood that is high in uric acid (also known as hyperuricemia).
  • Any intestinal problems, such as a blockage.

Diabetes: If you have diabetes, pancrelipase might affect your blood sugar levels. Your diabetes treatment plan, including medications, exercise, and diet, might need adjustments based on these readings.

Other Important Precautions

Pre-Surgical Care: When preparing for surgery, you must inform your doctor about all the medications you’re taking. This includes not just prescription drugs but also over-the-counter medicines and herbal products.

Use During Pregnancy & Breastfeeding: Pancrelipase should only be used during pregnancy if it’s clearly necessary. Also, It’s not known if pancrelipase passes into breast milk. Therefore, consult your doctor before you start breastfeeding while on this medication.

Missed Dose

If you forgot to take your Creon dose, just skip it and take the next one at your usual time. Don’t take two doses together, as it can lead to more side effects. To help remember, you can use a reminder like setting an alarm or using a phone app.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]


If you consumed Creon capsules more than recommended doses, call your doctor immediately. You can also contact the American Association of Poison Control Centers or use their online resources. If you have serious symptoms like high uric acid or issues with your colon, call 911 or go to the nearest emergency center right away.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]


  • Store Creon capsules at room temperature between 15°C & 25°C (59°F to 77°F), and make sure to keep it away from moisture. 
  • You can also store it temporarily at temperatures between 25°C and 40°C (77°F to 104°F) for up to 30 days. 
  • If Creon is exposed to temperatures and moisture exceeding 70%, it should be thrown away. 
  • After opening, always tightly close the bottle when not in use to protect it from moisture.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Creon Interactions

Drug Interactions with Creon

Alpha-Glucosidase Inhibitors

These inhibitors, prescribed for type 2 diabetes, may experience reduced effectiveness when taken concurrently with Creon. Creon, designed to replace digestive enzymes, counteracts the action of alpha-glucosidase inhibitors by slowing down certain digestion-related enzymes, potentially neutralizing their effects. Examples of alpha-glucosidase inhibitors include Acarbose and miglitol (Glyset), which may interact with Creon.


Creon’s efficacy can be compromised when taken alongside antacids, commonly used for indigestion and heartburn relief. The antacid may bind to Creon, hindering its absorption and resulting in insufficient levels of Creon in the body for the medication to be effective. Examples of antacids that may interact with Creon include calcium carbonate (TUMS), aluminum hydroxide/magnesium hydroxide (Maalox), and calcium carbonate/magnesium hydroxide/simethicone (Rolaids).

Other Creon Interactions


Sodium bicarbonate supplements, often used as antacids, may reduce Creon’s effectiveness. Your doctor may advise taking sodium bicarbonate at least 1 hour before or 2 hours after Creon to minimize this interaction.


While there are no specific reports of herbal interactions with Creon, it’s crucial to consult your doctor or pharmacist before using herbs during Creon treatment.


No specific reports of vitamin interactions with Creon exist, but it’s advisable to discuss any vitamin supplements with your doctor or pharmacist before taking them with Creon.


No specific food interactions with Creon have been reported. Consult your doctor for guidance on dietary considerations during Creon’s treatment.


There are no reported vaccine interactions with Creon. Discuss any concerns about getting vaccines during Creon’s treatment with your doctor.

Lab Tests

No reports suggest lab tests interact with Creon. Consult your doctor for information on specific lab tests while taking Creon.


While no known interactions exist between Creon and alcohol, excessive alcohol consumption can harm the pancreas, exacerbating the condition Creon is prescribed to treat. Consult your doctor or pharmacist regarding alcohol consumption while on Creon.

[Note: This isn’t a complete list, and there could be other drugs that interact with Creon. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Creon Alternatives

  • Zenpep (pancrelipase)
  • Pancreaze (pancrelipase)
  • Viokace (pancrelipase)
  • Pertzye (pancrelipase)
  • Lactaid (natural enzymes)

[Note: Your healthcare provider will determine the most suitable option for you. Refrain from using any alternative medications without first consulting your doctor. Self-administering these medications may lead to severe side effects.] 

Quick Tips

Frequently Asked Questions

Does Creon cause weight loss?

Creon is a medication that helps your body break down and use fats, proteins, and carbs for energy and nutrition. It doesn’t typically lead to weight loss. Instead, it can help your body store extra calories, possibly leading to weight gain. This weight gain can be healthy, especially for cystic fibrosis patients who take pancreatic enzyme replacements like Creon. If you’re concerned about how Creon affects your weight, it’s best to discuss it with your doctor.

How do I know if Creon is working?

To check if Creon is effective, record your treatment for the first few weeks using a Treatment Tracker. This helps you monitor how you’re feeling. If you notice or experience any unusual symptoms, visit your doctor immediately to schedule a face-to-face or online appointment. When you meet with your doctor, show them your Treatment Tracker so you can talk about how well the treatment works for you.

When should I stop taking Creon?

Make sure to listen to your doctor and keep taking Creon as they recommend you. Don’t stop taking it unless your doctor says it’s okay to do so. If you’re going to start any new medicines, let your doctor and pharmacist know that you’re already taking Creon.

Is EPI serious?

If you have EPI, it can make it hard for your body to break down food, which might lead to not getting enough nutrients. This can cause serious problems like malnutrition. So, if you think you might have EPI, talk to your doctor. If your doctor confirms you have EPI and gives you a treatment plan, make sure to follow it exactly as your doctor tells you.

Can you stop Creon suddenly?

No, you can’t stop Creon doses suddenly without your doctor’s recommendation. Do not use this Creon for any other purpose other than the purpose the doctor prescribes for you. Moreover, after quitting, Creon doesn’t affect your ability to drive or use machines.

Our Guarantee

At, we assure you the most affordable price to buy Creon from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently access Creon capsules at a substantial cost, call us at 1-888-779-2193 toll-free.


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