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Pancrelipase 

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Creon is an FDA-approved medication that is used to treat exocrine pancreatic insufficiency in adults & children. It contains pancrelipase, a combination of digestive enzymes including lipase, protease, and amylase. It is available in delayed-release capsules with varying strengths: Creon 3,000, Creon 6,000, and Creon 12,000, denoting the lipase units per capsule. For safe and efficient medication use, consult a licensed healthcare professional and ask if you have any queries or concerns regarding medication use. 

Product Overview 

Creon is a medication that contains pancrelipase, a combination of digestive enzymes including lipase, protease, and amylase. These enzymes help in the digestion of fats, proteins & carbohydrates, making Creon essential for individuals with exocrine pancreatic insufficiency (EPI).

Creon is available in delayed-release capsules with varying strengths: Creon 3,000, Creon 6,000, and Creon 12,000, denoting the lipase units per capsule. Swallow the capsule whole with a meal or snack and a full glass of water. Creon is suitable for both adults and children with EPI. It supplements the body with necessary enzymes to improve nutrient absorption and manage EPI symptoms.

Common side effects of Creon may include abdominal pain, dizziness, and abnormal bowel movements. You should follow the prescribed dose, avoid doubling doses if missed, and seek medical assistance in case of an overdose. Store Creon at room temperature, away from moisture and light. Consult your doctor for personalized medical advice and report any unusual symptoms promptly. 

Uses of Creon

It is used to treat:

• Exocrine pancreatic insufficiency in adults and children 

Benefits of Creon

• Creon functions by restoring the lost enzymes.

Side Effects of Creon

Common Creon side effects may include:

• Abdominal pain 
• Dizziness
• Frequent or abnormal bowel movements
• Gas
• Hyperglycemia
• Hypoglycemia 
• Sore throat and cough
• Vomiting

[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]

Creon Dosage

Forms & Strengths

Creon is available as a delayed-release capsule to be taken orally by mouth. It contains a mixture of enzymes, including lipases, proteases, and amylases. Here are the available strengths of Creon capsules:

• Creon 3,000:
  • 3,000 lipase units
  • 9,500 protease units
  • 15,000 amylase units
• Creon 6,000:
  • 6,000 lipase units
  • 19,000 protease units
  • 30,000 amylase units
• Creon 12,000:
  • 12,000 lipase units
  • 38,000 protease units
  • 60,000 amylase units

Recommended Dosages

Dosage for Patients with EPI

For Adults with EPI caused by Cystic Fibrosis 

• The initial dose is 500 lipase units per kg of body weight to be taken orally with each full meal. 
• The maximum recommended dose is 2500 lipase units per kg. 

For Adults with EPI Caused by Pancreatectomy, Pancreatitis, or Other Conditions 

• The medication dosage is based on the severity of your condition and the amount of fat in your diet and stools. 
• The initial recommended dose is 500 lipase units per kg per full meal. 
• You will typically start taking Creon at a low dose and gradually increase it depending on your body’s response to treatment. 

For Pediatric Patients Aged Less Than 12 Months 

• The recommended dose for infants from birth to 12 months is 3000 lipase units per breastfeeding or for every 120 ml of formula consumption. 

For Children Aged One Year to 4 Years 

• The recommended dosage for this age group is 1000 lipase units daily per kg of body weight. 
• The maximum dose for Creon is 2500 lipase units/kg of body weight per meal daily.  

How to Take Creon?

• Before taking Creon, you should carefully read and follow the instructions for use that came with your prescription label. Ask your doctor if you have any questions or concerns or do not understand any part of the leaflet. 
• You should take Creon exactly as prescribed by your doctor. 
• You should take this medication orally by mouth with a meal or snack. 
• You should swallow this medication as a whole with a full glass of water. Do not crush, chew, open, or break the capsule.
• Do not hold the capsule inside your mouth, as it can cause irritation inside your mouth. 
• Do not mix the medication with breast milk or infant formula. 
• Do not allow the medication to touch your skin. Also, do not inhale it, as it can cause irritation, especially to your lungs or nose. 
• Tell your doctor immediately if you notice any weight change. The dose of this medication is based on weight, and any change in weight may affect the medication dosage. 
• To get the most benefit from your medication, you should maintain consistency in dosage and get your prescription refilled before you completely run out of this medication. 
• Let your doctor know if your condition does not improve or worsen. 

Missed Dose 

• If you have missed a dose of Creon, you should take it with the next meal or snack. 
• You should only take one dose at a time. Do not take double or extra doses to compensate for the missed dose. 

[Note: Do not take two doses of Creon simultaneously to compensate for a missed dose. This can increase your risk of experiencing unwanted side effects.]

Overdose

You should not take this medication in large amounts, more frequently, or more than prescribed by your doctor, as it can cause medication overdose, which can further lead to unwanted side effects. If you suspect an overdose of Creon, you should immediately seek medical assistance. You can call your doctor, 911, or poison control helpline. You can also head to the nearest emergency room. 

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Creon Work?

Creon provides essential digestive enzymes to individuals with exocrine pancreatic insufficiency (EPI), a condition in which the pancreas doesn’t produce an adequate amount of enzymes to digest food properly. Lipase, protease, and amylase enzymes help break down fats, proteins & carbohydrates in the small intestine. By taking Creon, patients can improve nutrient absorption and manage EPI symptoms effectively. 

Important Safety Precautions

• Before taking this medication, tell your doctor if you have an allergy to it, to any of its ingredients, or to pork. Creon may contain certain inactive ingredients that may cause allergic reactions or other problems. Ask your pharmacist or healthcare provider for this product’s full list of ingredients. 
• If you have diabetes type 1 or 2, this medication may affect your blood sugar. You should regularly check your blood glucose and share the report with your doctor. Your doctor may need to adjust your medication, diet, or exercise program. 
• If you plan to undergo surgery, including a dental procedure, tell your doctor, surgeon, or dentist about all your medications, including Creon. 
• If you are pregnant, you should take this medication only when it is needed. Tell your doctor if you are planning to become pregnant or suspect a pregnancy. 
• It is unknown whether Creon passes into your breast milk. Consult your doctor before breastfeeding a baby while taking this medication. 
• If you experience symptoms of a rare but severe bowel disorder, such as vomiting, bloating, diarrhea, constipation, or unusual stomach pain, you should immediately call your doctor. 

Storage

• You should store Creon at a controlled room temperature of 15°C-25°C or 59°F-77°F, away from direct sunlight, excess heat, and moisture. 
• You should discard this medication if it is exposed to higher temperatures and more than 70% humidity. 
• Keep all medications away from the sight and reach of children and pets. 
• You should not use medications that have passed their expiration date. Discard them safely in such a way that children, pets, and others are not able to consume them. 

Creon Interactions

• Acarbose 
• Aluminum hydroxide
• Calcium carbonate
• Carbonyl iron
• Ferric maltol
• Folic acid
• Glycerol phenylbutyrate
• Heme iron polypeptide
• Leucovorin 
• Levomefolate calcium
• Magaldrate 
• Magnesium hydroxide
• Miglitol 
• Multivitamin with iron
• Multivitamins with iron and fluoride
• Multivitamin with minerals
• Multivitamin, prenatal
• Quinapril 
• Sodium bicarbonate

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Creon Alternatives

• Viokace (pancrelipase tablets)
• Pancreaze (pancrelipase delayed-release capsules)
• Pertzye (pancrelipase delayed-release capsules)
• Zenpep (pancrelipase delayed-release capsules)

[Note: Your healthcare provider will choose which Creon alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

Can Creon be taken with other medications?

Creon can interact with several medications, including antacids and iron supplements. It is essential to tell your doctor or healthcare provider about all the medications & supplements you are currently taking or planning to take to avoid potential interactions and adjust dosages if necessary. 

What should I do if I experience severe side effects while taking Creon?

If you experience severe side effects such as severe abdominal pain, persistent vomiting, or signs of a severe allergic reaction, you should immediately seek medical attention. Contact your doctor, call 911, or visit the nearest emergency room.

How long does it take for Creon to start working?

Creon typically begins to work shortly after ingestion, aiding in the digestion of food during meals or snacks. However, the full benefits may take a few days to become noticeable as your body adjusts to the enzyme supplementation.

Is it safe to take Creon during pregnancy or while breastfeeding?

The safety of Creon during pregnancy and breastfeeding is not well established. You should take Creon only if clearly needed and prescribed by your doctor. Discuss the potential risks & benefits with your doctor if you are pregnant, suspect a pregnancy, or planning to breastfeed.

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