Ivabradine
Buy Corlanor Online
Corlanor is a specialized medication designed to treat stable chronic heart failure by effectively lowering heart rate without impacting blood pressure. Available in tablet and oral solution forms, it enhances heart function and reduces hospitalization risks. It requires twice-daily dosing with meals and careful monitoring for potential side effects like bradycardia and hypertension. Patients should avoid grapefruit and consult healthcare providers about interactions with other medications.
Product Overview
Corlanor (ivabradine) is a heart medication primarily used to treat stable chronic heart failure and manage symptoms in adults with a reduced ejection fraction. By selectively inhibiting the funny current (If) in the sinoatrial node—the heart’s natural pacemaker—Corlanor effectively lowers heart rate without affecting blood pressure or contractility. This reduction in heart rate decreases the heart’s oxygen demand, improving heart function and enhancing the quality of life for heart failure patients.
Corlanor is available in tablet form (5 mg and 7.5 mg) and as an oral solution for those with difficulty swallowing. It is typically taken twice daily with meals. Key benefits of Corlanor include reduced hospitalization rates due to worsening heart failure, better symptom management, and heart rate control. Common side effects may include bradycardia, hypertension, and luminous phenomena.
Patients should avoid grapefruit and closely monitor interactions with other medications, especially those affecting heart rate and rhythm. Safety precautions include regular heart monitoring and consultation with healthcare providers regarding any potential pregnancy or interactions with other medicines. Always store Corlanor in a cool, dry place away from children and check the expiration date regularly.
Uses of Corlanor
- Chronic Heart Failure: Manages symptoms in adults with stable chronic heart failure.
- Reduced Ejection Fraction: This is specifically used for patients with a reduced left ventricular ejection fraction.
- Heart Rate Control: Aids in lowering heart rate in heart failure patients.
- Hospitalization Prevention: Helps reduce the risk of hospitalizations due to worsening heart failure.
Benefits of Corlanor
- Heart Rate Reduction
- Improves Heart Function
- Symptom Management
- Reduces Hospitalizations
- Enhances Quality of Life
Side Effects of Corlanor
Common Corlanor side effects may include:
- Bradycardia
- Hypertension
- Atrial Fibrillation
- Luminous Phenomena (Phosphenes)
- Dizziness
- Fatigue
[Note: This list is not exhaustive; if you notice any other symptoms not mentioned above, consult your doctor immediately.]
Corlanor Dosage
Forms & Strengths
- Tablets:
-
- 5 mg
- 7.5 mg
- Oral Solution: Available for patients who have difficulty swallowing tablets.
Recommended Dosages
Starting Dose for Adults:
- 5 mg taken twice daily with meals.
Maintenance Dose for Adults:
- Adjust based on heart rate and tolerance, typically 2.5 mg to 7.5 mg taken twice daily.
Starting Dose for Pediatric Patients (6 months and older):
- The initial dose is based on body weight and is given twice daily.
- For weight ≥ 40 kg: 5 mg twice daily.
- For weight < 40 kg: The healthcare provider determines the dose, typically starting at 0.05 mg/kg twice daily.
Maintenance Dose for Pediatric Patients:
- Adjust based on heart rate and tolerance under close supervision of a healthcare provider.
How to Take Corlanor?
- Follow Prescription: Take Corlanor precisely as prescribed by your healthcare provider.
- With Food: Take the medication with food to enhance absorption.
- Dosage Timing: Usually taken twice daily, so follow the timing specified by your doctor.
- Swallow Whole: Swallow the tablet whole; do not crush, chew, or break it.
- Regular Monitoring: Have regular check-ups to monitor your heart rate and overall response to the medication.
- Avoid Grapefruit: Do not consume grapefruit or grapefruit juice while taking Corlanor, as it can interfere with the medication.
Missed Dose
If you miss a dose of Corlanor, take it as soon as you remember, but only if it’s within 12 hours of your scheduled dose. If it’s been over 12 hours, skip the missed dose and resume your usual dosing schedule. Do not take two doses at once.
[Note: Do not simultaneously take two doses of Corlanor to compensate for a missed dose. This can increase your risk of experiencing side effects.]
Overdose
An overdose of Corlanor can cause severe bradycardia (slow heart rate), dizziness, fainting, or severe low blood pressure. If you suspect an overdose, seek emergency medical attention immediately. Symptoms may include fatigue, weakness, confusion, or chest pain. Contact poison control or emergency services without delay.
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Corlanor Work?
Corlanor (ivabradine) works by selectively inhibiting the funny current (If) in the sinoatrial node, the heart’s natural pacemaker. This action slows the heart rate without affecting blood pressure or contractility. By reducing the heart rate, Corlanor decreases the heart’s oxygen demand, which is beneficial for patients with chronic heart failure or angina. Slower heart rates allow for improved ventricular filling and increased heart pumping efficiency, thereby helping to manage symptoms and improve outcomes in heart failure patients.
Important Safety Precautions
- Monitor Heart Rate: Regularly check your heart rate, especially if you experience symptoms like dizziness or fatigue.
- Avoid Grapefruit: Refrain from consuming grapefruit or grapefruit juice, as it can affect how Corlanor works.
- Watch for Visual Disturbances: Be aware of any vision changes, such as seeing flashes of light, and report them to your doctor.
- Discuss Pregnancy: Consult your healthcare provider if you are pregnant or plan to become pregnant while taking Corlanor.
- Check for Interactions: Review all current medications with your doctor to prevent potential drug interactions.
- Manage Blood Pressure: Keep track of your blood pressure, as Corlanor may cause fluctuations.
- Report New or Worsening Symptoms: Immediately inform your doctor of any new symptoms or worsening conditions.
Storage
- Room Temperature: Store Corlanor at room temperature, between 68°F and 77°F (20°C and 25°C).
- Dry Place: Keep the medication dry, away from moisture and humidity. Avoid storing it in the bathroom.
- Original Packaging: Store Corlanor in its original packaging to protect it from light and moisture.
- Keep away from Children: To prevent accidental ingestion, ensure that Corlanor is out of the reach and sight of children.
- Avoid Extreme Temperatures: Do not expose Corlanor to excessive heat or freezing conditions.
- Check Expiry Date: Regularly check the expiration date and do not use the medication past this date.
Corlanor Interactions
- CYP3A4 Inhibitors: Medications such as ketoconazole, clarithromycin, and ritonavir can increase Corlanor levels, raising the risk of side effects.
- CYP3A4 Inducers: Drugs like rifampin, phenytoin, and St. John’s Wort can decrease Corlanor’s effectiveness by lowering its blood levels.
- Other Heart Medications: Combining with beta-blockers or certain calcium channel blockers (e.g., verapamil, diltiazem) can excessively slow heart rate.
- Antiarrhythmics: Medications like amiodarone may have additive effects on heart rate.
- QT-Prolonging Drugs: Using drugs that prolong the QT interval (e.g., sotalol, haloperidol) can increase the risk of arrhythmias.
- Grapefruit: Avoid grapefruit and grapefruit juice as they can increase blood levels of Corlanor, leading to potential side effects.
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
Corlanor Alternatives
- Toprol XL (metoprolol succinate)
- Coreg (carvedilol)
- Bystolic (nebivolol)
- Zebeta (bisoprolol)
- Cardizem (diltiazem)
- Calan (verapamil)
- Vasotec (enalapril)
- Altace (ramipril)
- Zestril (lisinopril)
- Cozaar (losartan)
- Diovan (valsartan)
- Digoxin (digoxin)
- Lasix (furosemide)
- Bumex (bumetanide)
- Aldactone (spironolactone)
- Inspra (eplerenone)
- Sacubitril/valsartan (entresto)
[Note: Your healthcare provider will choose the Corlanor alternative best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
How long does Corlanor remain in your system?
Corlanor typically stays in your system for approximately 30 hours after a single dose. This duration is based on its half-life, which indicates the time it takes for the drug’s concentration in the body to reduce by half.
Does Corlanor lead to weight gain?
Weight gain has not been identified as a side effect in studies of people taking Corlanor. However, unexpected weight gain could indicate that your heart failure is worsening. Discuss with your healthcare provider how frequently you should weigh yourself and at what point you should report excessive weight gain.
Does Corlanor have the potential to lower blood pressure?
Preliminary evidence indicates that Corlanor might lower blood pressure, but further research is needed to confirm this effect. Consequently, it is advised that individuals with notably low blood pressure should exercise caution or avoid taking Corlanor, given its potential to reduce blood pressure further.
Can Corlanor cause atrial fibrillation?
Yes, Corlanor has been known to heighten the risk of atrial fibrillation (AFib), a type of irregular heartbeat. Your healthcare provider must regularly monitor your heart rhythm to catch any irregularities early. If you notice symptoms like a racing heart, shortness of breath, chest discomfort, or significant fatigue, immediately seek medical help or inform your healthcare provider.
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