Naltrexone / Bupropion
Buy Contrave Online from Trusted Canadian Pharmacy
Contrave is an FDA-approved medication designed for weight management and is taken as an extended-release oral tablet. It combines naltrexone and bupropion to target different brain areas involved in appetite regulation and mood. Suitable for long-term use, Contrave helps reduce appetite, control cravings, and improve eating habits, potentially benefiting those with weight-related health conditions like high blood pressure and diabetes. Common side effects include insomnia, dizziness, and gastrointestinal discomfort. It requires careful adherence to dosage schedules and is not suitable for everyone, with specific precautions for individuals with certain health conditions.
Product Overview
Contrave (naltrexone/bupropion) is an extended-release oral tablet prescribed for weight management, particularly in adults struggling with obesity or weight-related health conditions. The medication is a combination of two active ingredients, bupropion and naltrexone, which work synergistically to suppress appetite and reduce food cravings. Naltrexone blocks certain brain receptors associated with the pleasure of eating, while bupropion, an antidepressant, helps maintain the availability of norepinephrine and dopamine, which influence mood and hunger signals.
Contrave is taken following a specific dosing schedule, starting with a low dose that gradually increases to a maintenance level, depending on individual responses and doctor recommendations. It can be taken with or without food, but high-fat meals should be avoided to reduce side effects.
While effective in promoting weight loss and improving dietary control, Contrave is not suitable for everyone. It is contraindicated in individuals with a history of seizures, untreated high blood pressure, or during pregnancy and breastfeeding. Side effects range from mild, such as dry mouth and headaches, to severe, including the risk of seizures and suicidal thoughts. Users must consult healthcare providers for tailored advice and closely monitor their health throughout treatment.
Uses of Contrave
- Weight Management
- Addiction Treatment
- Appetite Control
Benefits of Contrave
- Promotes significant weight loss when combined with a reduced-calorie diet and exercise.
- Helps curb appetite and reduce food cravings.
- It may improve control over eating habits and portion sizes.
- A combination of two different medications (naltrexone and bupropion) targets different areas of the brain involved in appetite regulation.
- Can lead to improvements in weight-related conditions, such as high blood pressure, high cholesterol, and type 2 diabetes.
- It may improve body image and self-esteem for those struggling with obesity.
- Generally well-tolerated, with a lower risk of side effects compared to some other weight-loss medications.
- Does not require injections or invasive procedures.
- Can be a useful long-term treatment option for chronic weight management.
- May help patients maintain weight loss over an extended period.
- Provides a safer alternative to weight-loss medications that have been withdrawn due to safety concerns.
Side Effects of Contrave
Common side effects of Contrave may include:
- Insomnia (trouble sleeping)
- Dizziness
- Dry mouth
- Headache
- Constipation
- Nausea
- Diarrhea
- Vomiting
[Note: This list is not exhaustive, if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]
Contrave Dosage
Forms & Strengths
Contrave is available as extended-release (ER) oral tablets. These tablets come in a single strength. Each tablet contains:
- 8 mg of naltrexone
- 90 mg of bupropion
Recommended Dosages
For Weight Loss & Weight Management:
- Starting Dosage: Treatment begins with a low dose and is gradually adjusted.
- Dosage Schedule:
- Week 1: Start with one tablet each morning.
- Week 2: Take two tablets daily, one in the morning and one in the evening.
- Week 3: Increase to three tablets daily, two in the morning and one in the evening.
- Week 4: Take four tablets daily, two in the morning and two in the evening.
- Maintenance Dosage: From week four onwards, the typical long-term dose is two tablets in the morning and two in the evening unless advised differently by your healthcare provider.
How to Take Contrave?
- Always swallow Contrave tablets whole. Do not crush, chew, or break the tablets.
- You can take Contrave with or without food. However, avoid consuming it with high-fat foods to reduce the risk of side effects.
- If you have difficulty swallowing tablets, consult with your healthcare provider about alternative methods for taking the medication.
- If you struggle with reading labels or opening containers, ask your pharmacist for accessible options. These can include large print labels, audio labels, or easy-open containers.
- Always adhere to your doctor’s instructions and consult them with any questions or concerns regarding your Contrave treatment.
Missed Dose
If you forget to take a dose of Contrave, simply skip the missed dose. Continue with your next dose at the regular scheduled time.
[Note: Do not take two doses of Contrave at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]
Overdose
An overdose of Contrave can lead to serious health issues. Watch for symptoms such as:
- Muscle jerks or twitches
- Hallucinations
- Seizures
- Loss of consciousness
- Irregular heartbeat
[Note: If you notice you have taken too much medication, call your local emergency number immediately.]
How Does Contrave Work?
Contrave contains two main components. First is Bupropion which is an antidepressant that primarily affects the brain chemicals norepinephrine and dopamine, which play a role in mood regulation. By maintaining the availability of these chemicals in the brain, bupropion improves the communication between nerve cells. Second is Naltrexone that blocks certain receptors in the brain, reducing the release of dopamine, which is associated with the pleasure derived from eating. While the exact mechanism of how naltrexone aids in weight loss isn’t fully understood, it is thought to influence the brain’s signals related to hunger and the feeling of satisfaction after eating.
Important Safety Precautions
Do not take Contrave if you have:
- Smoking Cessation
- Triggering of Manic Episodes
- Seizures
- Low Blood Sugar
- Untreated or Unmanaged High Blood Pressure
- Allergic Reaction
- Also, do not take Contrave if you’re breastfeeding, pregnant, or on birth control.
[Note: There’s a risk of suicidal thoughts and behavior. If you are feeling depressed and having these thoughts, contact your doctor immediately.]
Storage
- Store the medication in a cool, dry area where the temperature stays below 25°C (77°F).
- Ensure the medication is kept out of reach of children to prevent accidental ingestion.
- Avoid Freezing
Contrave Interactions
Here are some interactions of Contrave with various substances (including medicines, foods, lab test, and beverages):
- Alcohol
- MAOIs (monoamine oxidase inhibitors)
- Opioids
- CYP2B6 Inducers
- Drugs Affected by CYP2D6
- Digoxin
- CYP2B6 Inhibitors
- Drugs That Increase Seizure Risk
- Dopaminergic Drugs
- High-fat meals
- Bupropion, one of the active ingredients in Contrave, can potentially cause false-positive results in urine drug tests for amphetamines.
[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]
Contrave Alternatives
- Nesina (alogliptin)
- Saxenda (liraglutide)
- Bydureon Bcise (exenatide)
- Invokana (canagliflozin)
- Victoza (liraglutide)
- Glucophage (metformin)
- Wegovy (semaglutide)
- Actos (pioglitazone)
- Byette (exenatide)
- Steglatro (ertugliflozin)
- Januvia (sitagliptin)
- Mounjaro (tirzepatide)
- Farxiga (dapagliflozin)
- Tradjenta (linagliptin)
- Ozempic (semaglutide)
- Jardiance (empagliflozin)
- Rybelsus (semaglutide oral)
- Adlyxin (lixisenatide)
- Zepbound (tirzepatide)
- Onglyza (saxagliptin)
- Avandia (rosiglitazone)
- Prescose (acarbose)
- Trulicity (dulaglutide)
[Note: Your healthcare provider will choose which Contrave alternative is best for you. Taking or consuming them by yourself may cause serious side effects.]
Frequently Asked Questions
Is Contrave the same as Ozempic?
Contrave and Ozempic are different medications used for weight management but have distinct mechanisms and uses. Ozempic is primarily used for managing diabetes and has weight loss as a secondary effect, administered through weekly injections. Contrave, on the other hand, is specifically designed for weight loss and appetite control. It is taken orally in pill form, focusing on modifying brain behavior to reduce appetite and increase feelings of fullness.
How fast will I lose weight on Contrave?
The rate of weight loss on Contrave can vary significantly between individuals. Clinical studies show that the most significant weight loss generally occurs after about 4 months (16 weeks) of consistent use as prescribed. Your overall results will depend on factors such as adherence to the medication, lifestyle changes, and individual metabolic differences.
Is Contrave better than Phentermine?
Contrave and Phentermine are both effective for weight loss but work in slightly different ways. Contrave helps decrease the desire to eat and enhances the sensation of fullness, while Phentermine primarily suppresses the appetite. Phentermine is often used as a short-term treatment option to achieve relatively quick results. In contrast, Contrave may be considered for longer-term use, given its dual action on appetite and satiety.
How long does it take for Contrave to work?
In clinical trials, many people experienced significant weight loss starting about 4 weeks after beginning treatment with Contrave. However, the exact timing and extent of weight loss results can vary from person to person based on individual health factors, compliance with the medication regimen, and lifestyle modifications.
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