Linaclotide 

Buy Constella Online 

Constella is an FDA-approved medication that is primarily used to treat chronic idiopathic constipation, irritable bowel syndrome with constipation (IBS-C), and functional constipation. It is important to note that the dosage recommendations for Constella may vary from person to person. Therefore, patients should only take their medication as per the doses mentioned on the prescription label unless directed otherwise. Lastly, it is advisable not to share Constella with another individual even if they have a similar condition. Doing so may cause serious complications, which can be life-threatening. 

Product Overview 

Constella, containing the active ingredient Linaclotide, is a prescription medication widely used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation. Linaclotide works by increasing the secretion of intestinal fluid, which helps soften stools and restore bowel movements. 

Constella is available in capsule form, typically in strengths of 72, 145, and 290 mcg. It should be taken once a day on an empty stomach, at least 30 minutes before the day’s first meal. Adults aged 18 and older can use Constella, but it is not recommended for children. While Constella is generally well-tolerated, some individuals may experience side effects like diarrhea, abdominal pain, or bloating. It is crucial to consult with a healthcare provider. 

Moreover, patients should inform their medical provider beforehand if they have a history of bowel obstructions or other severe gastrointestinal conditions. Patients should follow their doctor’s guidance on dosage and usage to minimize risks. Regular follow-ups with a medical professional are advised to monitor progress & adjust treatment as necessary.

Uses of Constella 

It is used for treating:

• Irritable Bowel Syndrome with Constipation (IBS-C)
• Chronic Idiopathic Constipation (CIC)
• Functional Constipation

Benefits of Constella

Below are some of the benefits of Constella capsules:

• It helps alleviate constipation by increasing the frequency of bowel movements.
• It reduces abdominal bloating, pain, or discomfort associated with IBS-C.
• Constella helps to soften stools, making them easier to pass.
• This medication increases intestinal fluid secretion, which aids in smoother bowel movements.
• It is usually considered safe for long-term use under the guidance of a healthcare provider.
• Constella is generally well-tolerated by most patients, with manageable side effects.

Side Effects of Constella 

Common Constella side effects may include:

• Nausea
• Fatigue
• Flatulence
• Weakness 
• Dizziness
• Abdominal pain
• Gas
• Stomach cramps
• Bloating
• Dehydration
• Diarrhea
• Headache

[Note: This list is not exhaustive; if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]

Constella Dosage

Forms & Strengths

It comes in the form of an oral capsule and has the following strengths:

• 72 mcg capsule
• 145 mcg capsule
• 290 mcg capsule

Recommended Dosages

It is important to note that the improvements in bowel symptoms will appear within the first week of taking Constella. However, the improvement in abdominal symptoms may take longer to show. Moreover, patients with severe diarrhea should avoid using this medication. Here are the average dosage recommendations for Constella:

Dosage for Irritable Bowel Syndrome with Constipation

• For Adults: Take 290 mcg orally once a day on an empty stomach. Take this medication 30 minutes before your first meal of the day. 
• For Children: This medication is contraindicated in children below the age of 6 years and is not recommended for children between the ages of 6 and 18 years.

Dosage for Chronic Idiopathic Constipation

• For Adults: Take 145 mcg orally once a day on an empty stomach 30 minutes before your first meal of the day. 
• For Children: This medication is contraindicated in children below the age of 6 years and is not recommended for children between the ages of 6 and 18 years.

How to Take Constella?

• Read your medication guide thoroughly before using this medication, and if you have any doubts, talk to your healthcare provider.
• Take this medication by mouth once daily or as your doctor prescribes. 
• Swallow the capsules as a whole with a glass of water.
• Avoid chewing, breaking, crushing, or splitting the capsules.
• If you cannot swallow the capsules, you can open them and mix the contents in a teaspoon of applesauce. Swallow the mixture immediately without chewing. 
• Do not store the mixture for later use.
• Another way to take this medication is to open the capsules and mix their contents into 30 ml of water. Thoroughly mix it for 20 seconds and drink it right away. 
• Take another 30 ml of water and swirl for 20 seconds. Drink the mixture to get your complete dose. 
• The water mixture can also be administered through a tube into the stomach, but for this step, you have to ask your medical practitioner for complete instructions. 

Missed Dose 

• If you have mistakenly missed a dose of Constella, take it as soon as possible.
• If it is almost time for the next dose, you may omit the missed dose and continue your regular dosing schedule. 
• Do not take double doses of Constella simultaneously to make up for the last dose.
• Use medication apps or set phone reminders to avoid skipping doses.
• Take each dose at the same time regularly to get the most benefit.

[Note: Do not take two doses of Constella at the same time to compensate for a missed dose. This can raise your chances of experiencing side effects.]

Overdose

Generally, patients are advised not to take an overdose of Constella, but if you have mistakenly taken an exceeding amount of daily dose, you can experience unusual symptoms like severe diarrhea, abdominal pain, or dehydration. If you are noticing such overdose symptoms, reach out to a medical expert or call 911.  

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Constella Work?

Constella (Linaclotide ) works by targeting specific receptors in the intestines known as guanylate cyclase-C receptors. When Linaclotide binds to these receptors, it increases the secretion of chloride & bicarbonate into the intestinal lumen. This process improves the fluid content within the intestines, resulting in softer stools and regular bowel movements. Additionally, this action helps to ease abdominal pain and discomfort associated with irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) by reducing visceral hypersensitivity. 

Important Safety Precautions

• Before starting your treatment with Constella, tell your healthcare provider if you are allergic to Linaclotide or any of its ingredients. The product may contain certain inactive components that can cause severe allergic reactions.
• When undergoing surgery or any medical procedure, inform your surgeon or medical provider about the products you use. This includes all prescription drugs, over-the-counter drugs, and herbal products.
• This medication may cause diarrhea as a serious side effect. So, if you have a history of dehydration, talk to a professional practitioner before taking this medication.
• If you are pregnant, planning to have a baby, or a breastfeeding woman, avoid taking this medication without consulting a medical professional. Discuss every risk and benefit before making any decision.
• Constella may cause dizziness or fatigue in certain patients. So, if you are habitual of drinking alcohol, tell your medical practitioner. In the meantime, avoid driving or operating any machines that require alertness. 

Storage 

• Store the capsules at room temperature of 15°C to 25°C.
• Keep your medication in its original container, away from extreme heat, moisture, and direct sunlight.
• Store it somewhere safe in a locked container, out of your children’s reach and sight.
• Do not keep the medication in damp places like the bathroom or near the sink.
• Do not flush the medication down the toilet.
• Discard the product when it exceeds its expiration date.
• Ask a medical professional or pharmacist how to dispose of the medication properly without harming the environment.
• To maintain its effectiveness, do not transfer the medication to another container.

Constella Interactions 

Linaclotide may interact with the following drugs. 

• Ethinyl estradiol
• Etonogestrel
• Idelalisib
• Levonorgestrel
• Levothyroxine
• Levothyroxine/liothyronine
• Liotrix
• Norethindrone
• Norgestrel
• Thyroid desiccated

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Constella Alternatives

• Amitiza (lubiprostone)
• Motegrity (prucalopride)
• Resolor (prucalopride)
• Movantik (naloxegol)
• Relistor (methylnaltrexone)
• Miralax (polyethylene glycol 3350)
• Dulcolax (bisacodyl)
• Senokot (senna)
• Colace (docusate sodium)

[Note: Your healthcare provider will choose which Constella alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions 

What happens if I take Constella on a full stomach?

Taking Constella on a full stomach may reduce its effectiveness and increase the likelihood of gastrointestinal side effects like diarrhea. For optimal results and to reduce potential side effects, it is recommended to take Constella at least 30 minutes before your first meal of the day.

Is it safe to use Constella for the long term?

Constella is generally considered safe for long-term use under the supervision of a healthcare provider. Regular monitoring by your doctor is necessary to ensure the drug continues to be effective and to manage any potential side effects that may occur over time.

Is Constella and Linzess the same?

Yes, Constella and Linzess are the same medication with different brand names. Both medicines contain the active ingredient linaclotide. They are used interchangeably to treat IBS-C and CIC, providing similar therapeutic effects and benefits.

What happens if I suddenly stop taking Constella?

If you suddenly stop taking Constella, your symptoms of constipation and abdominal discomfort may return within one of discontinuing. It is important to consult your healthcare provider before discontinuing the medication to discuss a proper plan for managing your symptoms.

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