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Carvedilol

Carvedilol Tablet

Carvedilol is an FDA-approved medication used to reduce cardiovascular mortality in patients who already have heart-related conditions. It contains Carvedilol as its active ingredient, a nonselective beta-blocker and alpha-1 blocker. It is available in the form of tablets and capsules with the strengths of 3.125 mg, 6.25 mg, 12.5 mg, 25 mg, and 10, 20 mg, 40 mg & 80 mg, respectively. The dosage depends on the patient’s weight, condition, and response to treatment. For safe and efficient medication use, follow your doctor’s advice and consult them for personalized guidance. Buy Carvedilol for hypertension, angina, and other cardiovascular problems online from the best Canadian online pharmacy. 

Product Overview

Carvedilol 12.5mg Tablet contains the active ingredient carvedilol, a nonselective beta-blocker and alpha-1 blocker. This medication effectively treats high blood pressure, heart failure, and angina by reducing the heart’s workload and helping the blood to flow more smoothly through the blood vessels. Carvedilol works by blocking beta and alpha receptors, which helps to decrease heart rate, blood pressure, and the strain on the heart.

Available in tablet form, the strengths of Carvedilol include 3.125 mg, 6.25 mg, 12.5 mg, and 25 mg. It should be taken orally with food to elevate absorption and minimize the risk of side effects. This drug is suitable for adults and can be safely prescribed to children in doses adjusted by weight. Patients should follow their doctor’s instructions carefully regarding dosage and timing to ensure effectiveness.

Common side effects of Carvedilol may include fatigue, dizziness, and headache. Patients should take precautions such as avoiding abrupt cessation of the medication to prevent severe adverse effects. If a dosage is missed, it should be taken as soon as remembered unless it is close to the time for the next dose. Carvedilol should be stored in a dark and dry place away from direct sunlight, open flame, excess heat, and not in the bathroom. Always ensure that the medication is kept out of reach of children and properly disposed of when no longer needed.

Uses of Carvedilol

It is used to treat:

  • High blood pressure
  • Congestive heart failure
  • Angina 
  • Left ventricular dysfunction 

How to Use Carvedilol?

Dosage

Carvedilol is available in the form of tablets and capsules. The strengths are as follows:

Form: Tablets 

Strengths: 3.125, 6.25, 12.5 and 25 mg

Form: Capsules

Strengths: 10, 20, 40, and 80 mg

Recommended Dosage for Different Patients

For High Blood Pressure

  • The initial dose to treat blood pressure is 12.5 mg once daily for two days. 
  • This may be increased to 25 mg once daily.
  • If your blood pressure does not go down enough, your doctor may increase your dose to up to 50 mg once daily. The dosage may be taken as a single dose or split into two doses. 

For Heart Failure

  • The initial daily dose for heart failure is 3.125 mg, taken two times daily for two weeks. Your doctor may gradually increase the dose every two weeks up to a maximum of 25 mg to 50 mg. 
  • The medication dosage depends on your weight and the condition being treated. 

For Angina

  • The initial daily dose is 12.5 mg, taken twice daily for two days- this may be increased to 25 mg taken twice daily. 
  • If your child is prescribed Carvedilol, your doctor will determine the dosage based on their weight. 

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • Before using the Carvedilol 12.5 mg tablet, carefully read and follow the directions for use given on the patient information leaflet for safe and efficient use. 
  • If you have any queries or concerns regarding medication use, consult your physician or pharmacist. 
  • Take this medication orally with food, by mouth, as directed by your doctor.  
  • Do not chew, crush, or break the Carvedilol tablet. Swallow it as a whole with a drink of water. 
  • If you have difficulty swallowing Carvedilol as a whole, there is a line on the tablet that allows you to break the tablet into two equal parts. Check the patient information leaflet to see if you can do this. 
  • The dosage of the medication is based on your condition and your body’s response to treatment. 
  • To decrease your risk of unwanted side effects, your doctor may advise you to initially start this medication at a low dosage and slowly increase your dosage. 
  • To get the best results from this medication, maintain consistency in dosage and take this medication regularly. 
  • To help you remember the dosage, take the medication around the same time every day. 
  • While treating hypertension, it may take one to two weeks before you start to notice the benefits of this medication. 
  • Continue taking this medication even if you feel well. 
  • Let your doctor know if your condition does not improve or worsen. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Carvedilol Work?

Carvedilol is an alpha-1 blocker and nonselective beta-blocker indicated for use in patients with heart failure, hypertension, and left ventricular dysfunction in people who are otherwise stable. It affects both beta receptors and alpha-1 receptors in the body. By blocking these receptors, Carvedilol has several effects, such as lowering blood pressure and heart rate by blocking beta-1 and beta-2 receptors. This reduces the force of the heart’s contractions and slows the heart rate. Carvedilol also blocks alpha-1 receptors, leading to the widening of blood vessels. This further helps lower blood pressure. Overall, Carvedilol’s action results in decreased workload on the heart and improved myocardial contractility, which benefits people with heart failure.

Important Safety Information

Side Effects

Common side effects of Carvedilol may include:

  • Dizziness
  • Diarrhea
  • Fatigue 
  • Headache 
  • Joint pain
  • Lightheadedness 
  • Low blood pressure

Mild side effects of Carvedilol may include:

  • Nausea 
  • Shortness of breath 

Adverse side effects of Carvedilol may include:

  • Bronchospasm
  • Worsening heart failure
  • Liver problems 

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings

  • You should not stop taking this medication abruptly without taking permission from your doctor, as your condition may worsen when you suddenly stop taking Carvedilol. Some patients who stopped taking this medication abruptly have had irregular heartbeat, chest pain, and heart attacks. If you are planning to stop taking this medication, talk to your doctor. If they decide to discontinue the medication, they may direct you to taper off the medication gradually. 
  • When you gradually stop this medication, you should temporarily limit your physical activity to reduce strain on your heart. Get medical help immediately if you develop tightness, pressure, and chest pain, which spreads to the jaw, neck, or arm, or if you experience trouble breathing, unusual sweating, or rapid/irregular heartbeat.

Boxed Warning

  • You should not abruptly stop taking the medication, as it can worsen your condition and may also lead to a heart attack. If you are planning to stop taking the medication, you should talk to your pharmacist or healthcare provider to know how to taper off the medication. 
  • Hypotension may also occur during the initial titration periods or in patients with heart failure. Patients should monitor their blood pressure on a regular basis and share the report with their doctor if they notice any significant changes. 

Precautions

  • Before taking the medication, let your doctor know if you are allergic to any of the ingredients present in the medication. 
  • Before starting to use this medication, share your personal and family medical history with your doctor, especially if you have the following conditions:
    • Certain types of heartbeats/ heart rhythm problems
    • Certain eye problems
    • Irregular/slow heartbeat
    • Second or third-degree atrioventricular block
    • Difficulty in breathing
    • Severe heart failure  
    • Sick sinus syndrome
    • Severe allergic reactions
    • Liver disease
    • Kidney disease
    • Blood circulation problems
    • A certain type of tumor
    • Hyperthyroidism 
    • Myasthenia gravis
  • This medication may make you feel drowsy or dizzy, or it may also cause you to faint. This is most likely to occur within one hour after taking your first dose or after taking an increased dose. 
  • Avoid driving, operating heavy machinery, or indulging in activities that require clear vision. Avoid alcohol and marijuana consumption while you are taking this medication. Do not take beverages or medications that contain alcohol. 
  • If you wear contact lenses, you may have dry eyes while taking this drug. 
  • If you are planning to have surgery, let your doctor or dentist know about all the medications you are taking, including carvedilol 12.5 mg tablet. This also includes all prescription, over-the-counter drugs, and herbal supplements you may be taking. 
  • This medication may prevent the rapid heartbeat you experience during hypoglycemia. You are at greater risk if you have diabetes, vomiting, nausea, fasting, or not eating regularly. This medication does not affect other symptoms of hypoglycemia, such as sweating and dizziness. 
  • If you have diabetes mellitus, this medication may make it harder for you to control your blood glucose levels. Monitor your blood sugar levels closely on a regular basis and share the report with your doctor. 
  • Call your doctor immediately if you have hyperglycemia symptoms, such as increased urination/thirst. Your doctor may need to adjust your dosage, diet, or exercise program. 
  • Pediatric patients may be at a greater risk of hypoglycemia while taking this medication, especially if they are facing nausea, vomiting, or if they are unable to eat properly. Tell your doctor immediately if your child is vomiting, is having symptoms of hypoglycemia, or if they are not able to eat properly. 
  • Geriatric patients may be at a greater risk of side effects, especially lightheadedness and dizziness. 
  • Let your doctor know immediately if you are pregnant, suspect a pregnancy, or if you are planning to become pregnant. You should not concieve while you are using Carvedilol as it may cause harm to the unborn baby. If you become pregnant, call your doctor and discuss with them the risks & benefits of using this drug. 
  • It is not known if Carvedilol passes into breast milk. It is unlikely to pass into breastmilk in large amounts and cause undesirable effects in the infant. Talk to your doctor before using Carvedilol while breastfeeding. 

Contraindications

Carvedilol is contraindicated for use in patients who have:

  • Asthma
  • Bronchitis
  • Cardiogenic shock
  • Emphysema
  • Heart block
  • Severe bradycardia
  • Severe hepatic impairment
  • Severe liver disease
  • Sick sinus syndrome
  • Untreated pheochromocytoma

Missed Dose

  • For the best results, it is crucial to maintain consistency in dosage and take the medication around the same time every day. 
  • If you missed a dose of Carvedilol 12.5 mg, take it as soon as you remember. 
  • However, if it is almost time to take the next dose, you can omit the missed dosage and take the next dose according to the regular dosing schedule. 
  • Do not take extra or double doses of the same medication to compensate for the missed dose, as it can cause unwelcome side effects. 
  • To prevent missing doses in the future, try setting a reminder on your phone. 

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

Overdose 

You should not take carvediol more or longer than recommended. Taking the medication more than prescribed can lower your blood pressure, make it difficult to breathe, and lower your heart rate. If someone has overdosed on the medication and is experiencing adverse symptoms such as trouble breathing, seizures, passing out, and inability to wake up, you should seek immediate medical help. You can call 911 or head to the nearest emergency room.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Storage

  • Keep the medications in their original container, away from excess heat, direct sunlight, and moisture. 
  • Do not store Carvedilol in the bathroom. 
  • Keep all medications, including Carvedilol 12.5 mg, in a safe place, away from the sight and reach of children. 
  • Do not keep medications that are outdated or no longer needed. Properly discard them. 
  • Do not flush the medications in the toilet unless instructed to do so. 
  • Do not pour the medications in the drain or throw them in wastewater or household garbage bins. 
  • Discard them so that children, animals, and others cannot consume them. 
  • The medicine take-back program is the best way to get rid of unwanted medications. 
  • Talk to your pharmacist or contact the local waste disposal company to get more information on properly disposing of unwanted medications. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Carvedilol Interactions

  • Alcohol
  • Amiodarone
  • Antidiabetic agents (e.g., insulin, metformin)
  • Barbiturates (e.g., phenobarbital)
  • Beta-blockers (e.g., propranolol, metoprolol)
  • Bupropion
  • Calcium channel blockers (e.g., verapamil, diltiazem)
  • Chlorpromazine
  • Cimetidine
  • Clonidine
  • Cytochrome P450 2C19 inhibitors
  • Cytochrome P450 2D6 inhibitors
  • Digoxin
  • Digitalis glycosides (e.g., digitoxin)
  • Diltiazem
  • Fluoxetine
  • Fluvoxamine
  • Grapefruit juice
  • Hydrochlorothiazide
  • Ibuprofen
  • Lidocaine
  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • Metformin
  • Naproxen
  • NSAIDs
  • Paroxetine
  • Phenobarbital
  • Phenothiazines (e.g., chlorpromazine)
  • Propranolol
  • Propafenone
  • Quinidine
  • Rifampin
  • Risperidone
  • Sertraline
  • Terbinafine
  • Thiazide diuretics
  • Thioridazine
  • Ticlopidine
  • Verapamil
  • Warfarin

[Note: This isn’t a complete list, and there could be other drugs that interact with Carvedilol. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Carvedilol Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

What are the key considerations when titrating Carvedilol dosage in heart failure patients?

When titrating Carvedilol dosage in heart failure patients, key considerations include their current heart failure status, their response to initial dosages, and any symptoms of adverse effects. It’s crucial to start with a low dose and gradually increase it while monitoring the patient’s tolerance and clinical response. Regular heart function and symptoms assessment is necessary to adjust the dose without exacerbating the condition.

Can Carvedilol be safely used in patients with comorbid conditions such as diabetes or hypertension?

Carvedilol can be used safely in patients with comorbid conditions such as diabetes or hypertension, but it requires careful monitoring. In diabetic patients, Carvedilol may mask some symptoms of hypoglycemia, such as rapid heartbeat; thus, regular blood sugar monitoring is advised. For hypertensive patients, Carvedilol’s effect on blood pressure can positively manage the condition, aligning with treatment goals.

What are the potential drug interactions to be mindful of when prescribing Carvedilol alongside other medications?

Potential drug interactions to consider when prescribing Carvedilol include interactions with other blood pressure medications, which can lead to an additive hypotensive effect. Caution is advised when combining Carvedilol with medications that avert or are metabolized by cytochrome P450 enzymes, such as fluoxetine or paroxetine, as they can alter Carvedilol levels. Additionally, concurrent use with insulin or oral diabetic medications requires monitoring due to the risk of masking hypoglycemia symptoms.

How does Carvedilol compare to other beta-blockers regarding efficacy and tolerability for managing heart failure or hypertension?

Compared to other beta-blockers, Carvedilol offers the advantage of blocking both beta and alpha receptors, leading to more significant vasodilation and less resistance in blood flow. This dual action makes it effective and well-tolerated in managing heart failure and hypertension, often with a lower incidence of typical beta-blocker-related side effects like fatigue and cold extremities. Studies have shown that Carvedilol improves survival rates in heart failure patients and offers effective blood pressure management.

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