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Ergotamine tartrate and Caffeine


Cafergot is a combination medication for treating and preventing various types of headaches and migraines. These types of pain are caused by expanded blood vessels in the head, and Cafergot helps by narrowing these blood vessels. This medication is formed by combining Ergotamine and Caffeine and is suitable for adults and children. Usually, doctors recommend taking 2 tablets for adults and 1 tablet for children. It is important to note that this medication is useful for migraine headaches only. 

Product Overview

Cafergot contains two main ingredients: ergotamine and caffeine. Ergotamine compresses blood vessels in the brain to treat acute migraine attacks, while caffeine enhances the absorption and effectiveness of ergotamine. Together, these components provide rapid relief from migraine symptoms.

The medication is available in an oral tablet & suppository form, with each tablet typically containing 1 mg of ergotamine & 100 mg of caffeine and 2 mg of ergotamine & 100 mg of caffeine, respectively.  It should be taken orally at the first sign of a migraine, as directed by your doctor. This medication is suitable for adults who suffer from migraines but should not be used for long-term or preventative treatment. 

Some of the common side effects of Cafergot include nausea, vomiting, and dizziness. If these effects persist, consult your doctor. Patients should avoid using Cafergot if they have cardiovascular diseases or high blood pressure. In case of a missed dose, do not double up; simply take the next dose as prescribed. Store Cafergot at room temperature, away from moisture and light. Follow your doctor’s guidance for safe and effective use.

Uses of Cafergot

It is useful for treating vascular headaches. These are:

  • Cluster headaches
  • Migraine, and 
  • Histaminic cephalalgia

Benefits of Cafergot

  • Provides relief from migraine and cluster headaches.
  • Absorbs quickly into the bloodstream.

Side Effects of Cafergot

Common side effects of Cafergot may include:

  • Nausea
  • Diarrhea
  • Difficulty in sleeping
  • Dry mouth
  • Itching
  • Dizziness
  • Restlessness
  • Upset stomach
  • Weakness
  • Troubled breathing

[Note: This list is not exhaustive; if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]

Cafergot Dosage

Forms & Strengths

  • Oral Tablet: 1mg/100mg
  • Rectal Suppository: 2mg/100mg

Recommended Dosages

For Adults
  • At the first sign of migraine, doctors usually recommend taking 2 tablets. 
  • Then, you can take 1 tablet after every 30 minutes if the pain persists. 
  • Each Cafergot tablet contains 1 mg of ergotamine and 100 mg of caffeine, so do not exceed 6 tablets in a day or 10 tablets in a week.
For Children
  • Take 1 tablet at the first sign of migraine attack.
  • Then, take an increased dose, as your doctor recommends, every 30 minutes if the pain disappears.
  • Do not consume more than 3 tablets in a day or 5 tablets in a week.

How to Take Cafergot?

  • Take the medication by mouth, with or without food, whatever your doctor prescribes.
  • Usually, two tablets are recommended at the time of migraine.
  • Find a quiet and dark place, and lie down there for at least 2 hours.
  • If the pain does not disappear within 30 minutes, take more medicines but follow your doctor’s instructions.
  • Do not cross the excessive limit of the dosage. 
  • Swallow the tablets as a whole with a full glass of water.
  • Do not chew, break, or crush the medicines.
  • Closely monitor your health progress to avoid any complications.
  • Take your doses at the same each day for effective results.

Missed Dose 

Missing a Cafergot dose does not have any serious effects. However, if you forget to take a dose, take it whenever you experience another headache. Use medication apps or set phone reminders to avoid missing doses.

[Note: Do not take two doses of Cafergot at the same time to compensate for a missed dose. This can increase your risk of experiencing serious side effects.]


It is usually advised to avoid taking excessive amounts of Cafergot, but if someone has overdosed on Cafergot medication and is experiencing symptoms like nausea, vomiting, troubled breathing, coma, shock, muscle pain, and chest pain, take immediate medical help or call 911. In such situations, doctors use activated charcoal and other symptomatic treatments to clean the excessive drug from the body. 

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Cafergot Work?

Cafergot is a prescription medication that contains ergotamine and caffeine. This medication is widely used to treat certain types of headaches, which include migraine and cluster headaches. Its action mechanism involves two main components:

  • Ergotamine: It belongs to the ergot alkaloids group of medicines, which helps constrict the expanded blood vessels in the head. This action relieves the dilation, which is a major reason behind migraine headache pain. 
  • Caffeine: It is a natural chemical that works on the central nervous system. This substance improves ergotamine absorption into the bloodstream and contributes to vasoconstriction, leading to contracted blood vessels in the head.

This combined action of ergotamine and caffeine helps provide relief from the shooting pain of migraine headaches.

Important Safety Precautions 

  • Do not use protease inhibitors and macrolide antibiotics with Cafergot, as it can increase the risk of peripheral ischemia in patients. Talk to your doctor before starting Cafergot treatment.
  • This medication can increase the risk of vasospasms; consult with a medical professional to avoid severe side effects.
  • Avoid using Cafergot if you have allergies to any of the medication’s ingredients. 
  • The medication has caused a lack of blood flow to the various parts of the patient’s body, like hands, feet, arms, or brain. This could result in stroke. If you notice symptoms such as chest pain or severe abdominal pain, immediately contact a doctor.
  • Avoid drinking too much alcohol as it may trigger headaches.
  • Do not use tobacco products with Cafergot as the combination may increase the risk of side effects like heart problems and reduced blood circulation.
  • Do not use this product when you are pregnant. It can harm the fetus, so discuss every risk and benefit with your doctor before making any decision.
  • The drug may likely pass into the breast milk. Therefore, make sure you are consulting with a medical practitioner before breastfeeding.
  • Before using this product, talk to your medical practitioner about your medical history, especially if you have blood circulation problems, heart issues, kidney or liver diseases, or a family background of substance abuse.
  • If you are undergoing any medical surgery, inform your doctor/dentist about all the products you use. This also includes prescription drugs, nonprescription drugs, and herbal products.


  • Store the medication in a cool place with a temperature below 25°C.
  • Keep it out of children’s sight and reach.
  • Avoid keeping the medicines in damp areas like the bathroom or near sinks.
  • Store it in its original container until you use the medication.
  • Do not keep your tablets in the car or window sills.
  • Stop using the medicines if it has reached its expiration date.
  • Discard the product in an appropriate container.
  • You can ask your pharmacist/doctor to know how to dispose of the product correctly.
  • Do not flush the medicines down the toilet.
  • Keep it away from heat or moisture.

Cafergot Interactions

A drug interaction happens when multiple drugs interact with each other, causing adverse effects. This further reduces the effectiveness of the medication. Therefore, patients need to be mindful of the drugs they are using to avoid any serious complications. Below is a list of a few drugs that may interact with Cafergot:

  • Almotriptan
  • Amprenavir
  • Atazanavir
  • Boceprevir
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Darunavir
  • Delavirdine
  • Dopamine
  • Eletriptan
  • Erythromycin
  • Fosamprenavir
  • Frovatriptan
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Letermovir
  • Levoketoconazole
  • Lopinavir
  • Mifepristone
  • Naratriptan
  • Nefazodone
  • Nelfinavir
  • Nirmatrelvir
  • Posaconazole
  • Riociguat

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Cafergot Alternatives

  • Rizatriptan
  • Maxalt
  • OnabotulinumtoxinA
  • Ubrogepant
  • Tizanidine
  • Verapamil
  • Sumatriptan
  • Imitrex
  • Ubrelvy
  • Nurtec ODT
  • Emgality
  • Zanaflex
  • Galcanezumab
  • Indomethacin

[Note: Your healthcare provider will choose which Cafergot alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

Who should not take Cafergot?

While Cafergot has its benefits, it is not suitable for every individual. Doctors usually contraindicate the usage of this medication in patients who are/have:

  • Pregnant
  • Nursing mothers
  • Peripheral vascular diseases
  • Coronary heart diseases
  • Hypertension
  • Sepsis

Can I use Cafergot for the long term?

No, Cafergot is not recommended for long-term use. The medication is designed for the acute treatment of migraine attacks. Patients are advised not to use this product as a preventative measure as it can lead to adverse side effects.

Can I drive or operate machinery while taking Cafergot?

Cafergot may cause dizziness in patients as a side effect. So, it is generally advised to avoid driving or operating any machinery that requires alertness.

Are there any dietary restrictions while taking Cafergot?

While there are no specific dietary restrictions for Cafergot, doctors mostly recommend avoiding grapefruit juice, as the combination of these two products may cause a drug interaction in the body. However, it is always a good idea to consult with your healthcare provider for any dietary recommendations.

Our Guarantee

At Arctic Meds, we guarantee that you will find the most competitive prices for purchasing Cafergot through our platform. As the best Canadian online pharmacy, we are committed to delivering only the highest quality products. Each order is fulfilled through a reputable and licensed Canada pharmacy online, ensuring that every product we ship meets stringent standards of quality and authenticity. Our reliable service ships your medications directly from Canada right to your doorstep. For seamless access to buy Cafergot online from Canada at a low price contact us.


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