Bosutinib

Buy Bosulif Tablets Online from Canada

Bosulif (bosutinib) is an FDA-approved medication categorized as a tyrosine kinase inhibitor. It is specifically designed to treat Philadelphia chromosome-positive chronic myelogenous leukemia in certain adults and children, a condition characterized by an abnormal chromosome that propels the disease. Administered orally in tablet or capsule form, Bosulif offers the convenience of once-daily dosing. It is advised for adult patients who fulfill specific criteria. If you are considering Bosulif for leukemia treatment, ensure you first obtain a prescription from your doctor.

Product Overview

Bosulif, also known as bosutinib, is an essential drug for treating Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML). The FDA has approved this medicine as a tyrosine kinase inhibitor, targeting specific proteins that help leukemia cells grow. It’s suitable for adults and children over one year old, especially those who haven’t had success with previous treatments or who can’t handle them. Bosulif is available in tablet and capsule forms, with tablets available in 100 mg, 400 mg, and 500 mg and capsules in 50 mg and 100 mg. 

The adult dosage is 400 mg daily for newly diagnosed cases and 500 mg for more advanced stages. Dosages for children are adjusted based on their body size. Following certain guidelines when taking Bosulif is important to get the best results and reduce side effects. Patients should take the medicine with food to help with absorption and lessen stomach upset. The tablets should be swallowed whole, not broken or crushed. Grapefruit & its juice should also be avoided, as they can interfere with how well the drug works. 

Furthermore, patients must be careful with other medicines that might affect Bosulif, particularly those that interact with the CYP3A4 enzyme. Patients may experience side effects like rashes, diarrhea, and fatigue, and in some cases, more severe issues such as liver damage or heart problems could occur. Regular check-ups with a doctor or a healthcare provider are important to monitor how well your treatment works and adjust the treatment plan if necessary.

Uses of Bosulif

Bosulif is approved for:

• Adults & children aged 1 year and older with Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) in its chronic phase. This includes:
  • Newly diagnosed patients.
  • Those who have not responded well to other treatments.
  • Those who cannot tolerate other treatments.

• Adults in more advanced stages of leukemia, such as the accelerated or blast phases, especially:
  • If previous treatments haven’t worked.
  • If previous treatments were not tolerated.

Benefits of Bosulif

• It is suitable for multiple patient groups.
• It is particularly beneficial for various patients who have not responded to previous treatments.
• Bosulif is taken orally, which is generally easier and more convenient than treatments requiring intravenous administration.

Side Effects of Bosulif

Common side effects of Bosulif may include:

• Fever
• High liver enzyme levels in the blood
• Rash
• Nausea
• Respiratory tract infection
• Fatigue
• Vomiting
• Diarrhea
• Headache
• Low blood cell counts
• High creatinine levels in the blood

[Note: This list is not exhaustive, if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]

Bosulif Dosage

Forms & Strengths

It is available in tablet & capsule form with the following strengths:

• Tablet: 100 mg 400 mg, & 500 mg 
• Capsules: 50 mg & 100 mg

Recommended Dosages

Recommended Dosage for Adults

• For newly diagnosed cases: Take 400 mg by mouth once daily.
• For chronic, accelerated, or blast phases: Take 500 mg by mouth once daily.

Recommended Dosage for Children

• For newly diagnosed cases: Take 300 mg/m² by mouth once daily.
• For chronic phase cases that are intolerant to previous therapies: Take 400 mg/m² by mouth once daily.

How to Take Bosulif? 

• Take with food to improve absorption and lessen stomach discomfort.
• Swallow tablets whole; don’t crush, chew, or break them. If broken, wash your skin immediately and consult your pharmacist for disposal instructions.
• Wear gloves, carefully open the capsules, and mix the contents with room-temperature applesauce or yogurt only. Consume immediately, and do not chew or store for later.
• Wear gloves when handling medication for children. Adjust dosage according to growth, as directed by a physician.
• Avoid taking Bosulif within 2 hours of antacids or H2 blockers. Before using Proton Pump Inhibitors (PPIs), check with your doctor or pharmacist.
• Do not consume grapefruit, its juice, or supplements containing grapefruit extract.
• Your dosage may need to be adjusted for reasons such as treatment toxicity or if you have kidney or liver issues.

Missed Dose 

If you miss a dose of Bosulif (bosutinib) for more than 12-hours, skip the missed dose of this medication & continue with your regular schedule. Do not take two doses at once. To maintain effective treatment, try to take your medication at the same time each day. Setting reminders or alarms can help you remember.

[Note: Do not take two doses of Bosulif at the same time to compensate for a missed dose. This can increase your chance of experiencing serious side effects.]

Overdose

If someone overdoses on Bosulif tablets and shows severe symptoms such as unconsciousness or difficulty breathing, call 911 immediately. For less severe overdose symptoms, contact a poison control center right away.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Bosulif Work?

Bosulif is a medication that targets and blocks BCR-ABL kinase, a protein that’s often overproduced in leukemia cells. By focusing on this protein, Bosulif helps to halt or slow the growth of chronic myelogenous leukemia (CML) cells. It also impacts other related proteins in the Src family of kinases, like Src, Lyn, and Hck, helping to control the disease’s progression further. Bosulif belongs to a class of drugs known as tyrosine kinase inhibitors, which work by disrupting key pathways essential for cancer cell growth and survival.

Important Safety Precautions

• Tell your doctor about any allergies before taking bosutinib, as it may contain ingredients that trigger reactions.
• Discuss your medical history, especially liver or kidney disease, before using bosutinib.
• Bosutinib can cause dizziness; avoid alcohol and marijuana, which can make this worse.
• Do not drive or use machinery until you can do so safely.
• Avoid alcohol to reduce the risk of severe liver problems.
• Tell your doctor or dentist about all medications you use before any surgery.
• Inform your healthcare provider about taking bosutinib before getting any vaccinations.
• Stay away from people who have received live vaccines recently.
• Be careful with sharp objects to prevent cuts and bruises, and avoid contact sports to reduce injury risk.

Storage

• Store Bosulif tablets at room temperature, 20°C-25°C (68°F-77°F).
• Short-term storage is okay between 15°C and 30°C (59°F to 86°F).
• Keep tablets away from direct sunlight in a dry place.
• Store in the original container with a tightly closed lid to keep out moisture.

Bosulif Interactions

• Be cautious about using other medications with Bosulif, as some can affect its effectiveness or increase side effects; always discuss all medications, including over-the-counter drugs, vitamins, and supplements, with your healthcare provider.
• Medications that influence the CYP3A4 enzyme, like certain antifungals (ketoconazole, fluconazole) and antibiotics (rifampin, clarithromycin), can change Bosulif levels in your body, possibly leading to increased toxicity or reduced efficacy.
• Avoid using proton pump inhibitors (PPIs) such as lansoprazole, pantoprazole, omeprazole, rabeprazole, esomeprazole, and dexlansoprazole with Bosulif, as they can decrease its absorption and effectiveness.
• Be mindful of supplements, especially those containing grapefruit extract, which can raise Bosulif levels and increase the risk of adverse effects.
• Avoid taking grapefruit or its juice while taking Bosulif, as it can increase drug levels in your body and heighten the likelihood of side effects.

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Bosulif Alternatives

• Sprycel (dasatinib)
• Gleevec (imatinib)
• Tasigna (nilotinib)

[Note: Your healthcare provider will choose which Bosulif alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is bosutinib a chemotherapy drug?

Yes! Bosutinib is a Chemotherapy Regimen for treating Chronic Myeloid Leukemia (CML).

Does Bosulif cause hair loss? 

Hair loss is not a common side effect of Bosulif. Clinical studies did not report it in individuals taking this medication.

Is bosutinib safe?

Yes, bosutinib is considered safe. It has demonstrated acceptable safety levels and manageable side effects in patients with Ph(+) leukemia.

How effective is bosutinib?

Bosutinib is highly effective as a frontline treatment for chronic phase CML (CP CML). Recommended frontline TKI therapies for newly diagnosed patients not only achieve excellent results but also lead to long-term overall survival rates that are comparable to those of the general population of the same age.

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