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Mometasone Furoate

Asmanex Twisthaler 

Asmanex (Mometasone Furoate) is an FDA-approved medication primarily prescribed as a preventive treatment for asthma. This medication is a type of corticosteroids that are potent anti-inflammatory agents that work by inhibiting the release of various chemicals in the body that contribute to inflammation. It is used to manage and reduce the frequency of asthma attacks by maintaining controlled inflammation levels in the respiratory passages. However, it is important to note that Asmanex is not designed to provide immediate relief from an asthma attack once it has already started. For sudden asthma symptoms, patients are advised to use a quick-relief inhaler as their healthcare provider prescribes. So, if you want to Buy Asmanex (Mometasone Furoate) online from Canada, you will need a doctor’s prescription.

Product Overview

Asmanex is a corticosteroid used primarily for long-term asthma management, aimed at preventing asthma attacks rather than treating them once they’ve begun. The active ingredient in this medication, mometasone furoate, works by releasing inflammatory substances in the body, thereby reducing inflammation in the airways. This FDA-approved medication is administered via a device called the Twisthaler, which delivers the drug in a powder form through inhalation​.

It’s important to use Asmanex strictly as prescribed by a healthcare provider. The medication should be inhaled orally, usually once or twice daily, depending on the patient’s previous asthma therapy and the specific Asmanex product used. For effective results, it may take up to two weeks of regular use to see an improvement in asthma symptoms. Users are advised not to use Asmanex as a rescue medication for sudden asthma symptoms but should instead use a fast-acting inhaler for such instances​.

Side effects of this medication can vary but commonly include respiratory issues such as wheezing or choking, vision changes like blurred or tunnel vision, signs of thrush (a yeast infection in the mouth), and systemic effects due to the suppression of the immune system by the steroid. Patients should discuss the potential for these side effects and the proper management of their condition with their doctor. Additionally, mometasone can impact growth in children, and long-term use of steroids might lead to bone density loss, making consultations on these risks essential​. 

Uses of Asmanex Twisthaler

Asmanex Twisthaler, containing the active ingredient mometasone, can be used to:

  • Control and prevent asthma symptoms
  • Reduce airway irritation and swelling
  • Improve daily functioning

How to Use an Asmanex Twisthaler?

Dosage

It comes in the form of inhalation powder and has these 3 strengths:

  • Asmanex Twisthaler 100 mcg inhaler (metered-dose)
  • Asmanex Twisthaler 200 mcg
  • Asmanex Twisthaler 400 mcg

Recommended Dosage for Different Patients

Standard Adult Dosage for Asthma Maintenance

  • Inhalation Aerosol Powder (Post-Bronchodilators or Inhaled Corticosteroids): Start with an initial dose of 220 mcg taken orally in the evening. The Asmanex dose can be increased to a maximum of 440 mcg, either split into two doses of 220 mcg or taken once daily as 440 mcg.
  • Post-Oral Corticosteroid Therapy: Begin with 440 mcg taken orally two times daily, up to a maximum of 880 mcg.

Inhalation Aerosol (Following Previous Corticosteroid Use)

  • Medium-Dose Corticosteroids: Two inhalations of 100 mcg taken orally twice a day.
  • High-Dose Corticosteroids or Oral Corticosteroids: Two inhalations of 200 mcg taken orally twice a day, with a maximum of 800 mcg per day.

For Ongoing Oral Corticosteroid Users

  • Gradually taper off prednisone starting after at least one week of treatment with this drug.
  • Regularly monitor for any signs of unstable asthma or adrenal insufficiency during and after the tapering of steroids.

Pediatric Dosage for Asthma Maintenance

  • For Children Under 4 Years: The use of this inhalation aerosol powder is not approved.
  • Ages 4 to 11: Administer 110 mcg orally once daily in the evening.
  • Ages 12 and Older: Follow the same adult dosage guidelines based on previous therapies.

For Children 12 Years and Older, Using Inhalation Aerosol

  • The same adult dosage for medium and high-dose corticosteroid therapies applies.

Ongoing Monitoring for All Patients

  • Keep a close watch for any changes in asthma symptoms and general health, especially when modifying the steroid regimen.

[Note: Remember these recommendations, as mentioned above, can vary depending on person to person. You need to discuss it with your doctor or pharmacist, and they’ll customize your Asmanex dosage accordingly.]

How to Take It?

  • Take off the cap from the Asmanex Twisthaler mouthpiece.
  • Asmanex Twisthaler is administered using a special inhaler device called a twisthaler, which is preloaded with the medication in powder form. The device releases a measured dose of mometasone as a fine spray of powder with each use.
  • Position your middle or index finger on the top of the canister and place your thumb under the mouthpiece.
  • Rapidly shake the inhaler for 5-10 seconds.
  • Exhale completely to prepare for inhaling the medication.
  • Insert the mouthpiece into your mouth & seal your lips around it. Ensure that your teeth or tongue do not obstruct the mouthpiece.
  • Press down firmly on the canister while taking a deep, slow breath through your mouth.
  • You need to hold your breath for 5-10 seconds, then exhale slowly.
  • If prescribed multiple doses, pause for at least 30 seconds before repeating the steps.
  • After using the inhaler, rinse your mouth with water to help prevent infections. Spit out the water instead of swallowing.
  • It may take up to 2 weeks for your symptoms to improve. Continue using the medication as directed and inform your doctor if there is no improvement after one week.

[Note: Your doctor or pharmacist will decide the right Asmanex amount to inhale for you based on your condition, following guidelines & studies on the drug. They’ll adjust it as needed over time.]

How Does Asmanex Twisthaler Work?

Mometasone, an active ingredient of Asmanex, is a type of medicine known as a corticosteroid. It’s used in an inhaler form to treat asthma in people who are 4 years old and older. The Asmanex Twisthaler works by reducing swelling in the lungs’ airways, which helps control asthma symptoms and prevent asthma attacks. For mometasone to be effective, it needs to be used regularly. However, it’s important to know that mometasone inhalers cannot stop an asthma attack once it has already begun.

Important Safety Information

Side Effects

Common side effects of Asmanex include: 

  • Headache
  • Allergy symptoms
  • Sore throat 
  • Cough
  • Nausea
  • Vomiting
  • Wheezing
  • Sinus infection
  • Muscle pain
  • Oral thrush
  • Tiredness

Mild side effects of Asmanex include: 

  • Fungal infection
  • Indigestion, upset stomach
  • Hoarseness or deepened voice
  • Menstrual pain
  • Flu symptoms

Serious side effects of Asmanex include: 

  • Muscle weakness in arms or legs
  • Chest pain or tightness
  • Stretch marks around the belly
  • Puffiness of the face
  • Easy bruising
  • Mood changes
  • Weight gain around your gut
  • Swelling of your face or tongue
  • Difficulty breathing

[Note: This list might not include all potential side effects. Consult your healthcare giver for medical advice regarding side effects.]

Warnings

Risk of Oral Fungal Infections: Asmanex (mometasone) is a steroid medication used for asthma, and when inhaled, it can cause a fungal infection known as thrush in the mouth and throat. Symptoms of thrush include white patches, a cotton-like feeling in the mouth, pain while eating or swallowing, and loss of taste. Immediate medical attention from a doctor is advised if these symptoms appear.

Risk of Bronchospasm: The risk of Bronchospasm, characterized by sudden muscle constriction in the bronchioles, can be triggered by Asmanex (mometasone). Symptoms may include breathing difficulties, wheezing, coughing, and chest discomfort. If such symptoms arise, it’s vital to promptly utilize a rescue inhaler and seek immediate medical assistance.

Severe Allergic Reactions: Serious and potentially life-threatening allergic reactions can occur with Asmanex. Symptoms may include facial swelling, shock, anaphylaxis, hives, rash, red skin, and swelling of the lips or tongue. Immediate medical intervention is critical if any of these symptoms are observed.

Increased Risk of Infections: Medications such as Asmanex (mometasone), classified as corticosteroids, have the potential to dampen the immune response, heightening vulnerability to infections and complicating the recovery process. If symptoms such as chills, fever, or body aches arise, seeking prompt medical attention is crucial.

Altered Stress Hormone Levels: Extended or excessive use of Asmanex can lead to abnormal absorption of the medication into the body, affecting natural cortisol levels. This can result in Cushing’s disease symptoms like weight gain, facial puffiness, and muscle weakness or symptoms of low cortisol like fatigue, loss of appetite, nausea, and vomiting.

Delayed Growth in Children: This medication may decrease the growth of children, or they may experience delayed growth. It is important for healthcare providers to monitor growth regularly during treatment and discuss potential impacts with caregivers.

Eye and Vision Problems: Long-term users of Asmanex may experience increased eye pressure, glaucoma, or cataracts. Regular eye exams are recommended for a person with a history of these conditions or those who notice changes in their vision during treatment.

Precautions

  • Asmanex should not be used if you have an allergy to mometasone or milk proteins. Before starting Asmanex, ensure its safety for your condition by discussing your medical history with your doctor, particularly if you have experienced:
    • Liver disease;
    • Herpes infection affecting the eyes;
    • Glaucoma, cataracts, or other vision issues;
    • Any illness or infection, including tuberculosis.
  • Asmanex should not be administered to children under the age of 4. 
  • Prolonged use of steroids, such as those found in Asmanex, can lead to bone loss (osteoporosis), particularly in individuals who smoke, lead a sedentary lifestyle, lack sufficient vitamin D or calcium in their diets, or have a family history of osteoporosis. Discuss with your doctor your risks and potential preventive measures regarding osteoporosis.

Other Important Precautions 

  • If you are pregnant, it is crucial to inform your doctor. The effects of mometasone on an unborn baby remain unclear. Nonetheless, not managing asthma effectively during pregnancy can lead to severe complications such as low birth weight, premature birth, or eclampsia, a condition characterized by dangerously high blood pressure that can cause severe health issues for both the mother & the baby. The advantages of treating asthma might outweigh the potential risks to the baby.
  • The safety of breastfeeding while using Asmanex is not established. Discuss any potential risks with your doctor.

Contraindications

Asmanex Twisthaler treatment is contraindicated in the first-line therapy for status asthmaticus or other sudden asthma attacks necessitating intensive measures.

Missed Dose

  • If you missed a dose of your medication, it’s important to take it as soon as you remember. However, if you realize you’ve missed a dose and it’s nearly time for your next scheduled dose, you can skip the missed dose altogether. 
  • Taking the missed dose too close to your next dose could lead to an overdose. Therefore, do not attempt to take two doses simultaneously to make up for the missed one. 
  • Always adhere to the regular dosing schedule moving forward.

[Note: Please consult your doctor or pharmacist immediately if you’ve missed a dose of your medication and are still determining when to take the next one.]

Overdose 

If someone has overdosed on Asmanex Twisthaler and exhibits severe symptoms like loss of consciousness or difficulty breathing, dial 911 immediately or call a poison control center immediately.

[Note: If you’ve taken more than the recommended dosage, seek immediate medical assistance or contact the Poison Help line at 1-800-222-1222.]

Storage

Store Asmanex at room temperature (25℃), away from moisture and heat. Upon first opening the foil pouch and removing the inhaler, note the date on the device. Dispose of the Asmanex Twisthaler when the dose counter indicates “00.” Keep the cap on the inhaler when not in use. Avoid exposing the inhalation aerosol canister to open flame or high heat, as the canister may explode if it overheats. Do not burn an empty canister. Do not wash the inhaler device or allow it to get wet. Clean the mouthpiece with a dry, clean tissue or cloth.

[Note: Consult your healthcare provider regarding the appropriate disposal of any unused medication and for any queries concerning its storage.]

Asmanex Twisthaler Interactions

Asmanex Twisthaler (mometasone) is known to have interactions with a total of 78 drugs, categorized based on the severity of interaction:

Major Drug Interactions: These interactions are considered significant and may need close monitoring or adjustment of medication dosages. They include Axicabtagene ciloleucel, Brexucabtagene autoleucel, Ciltacabtagene autoleucel, Cladribine, Desmopressin, Dinutuximab, Idecabtagene vicleucel, Lisocabtagene maraleucel, Mifepristone, and Nadofaragene firadenovec. These drugs, when taken with Asmanex Twisthaler, can lead to serious effects or reduced efficacy of either medication.

Moderate Drug Interactions: These interactions are of intermediate severity and may necessitate adjustments in medication timing or dosages. Examples include Abametapir topical, Adagrasib, Amprenavir, Atazanavir, BCG, Belzutifan, Boceprevir, Capivasertib, Ceritinib, Clarithromycin, Cobicistat, Conivaptan, Darunavir, Delavirdine, Echinacea, Erythromycin, Fosamprenavir, Fostamatinib, Idelalisib, Indinavir, Indium oxyquinoline In-111, Insulin inhalation, rapid acting, Itraconazole, Ketoconazole, Lenacapavir, Levoketoconazole, Lonafarnib, Lonapegsomatropin, among others. While not as severe as major interactions, these combinations may still pose risks or affect the effectiveness of treatment.

Minor Drug Interactions: These interactions are generally less severe but still worth noting as they may cause mild side effects or alter the intended effects of the medications involved. Examples include Albuterol, Arformoterol, Bitolterol, Formoterol, Indacaterol, Isoetharine, Isoproterenol, Levalbuterol, Metaproterenol, Pirbuterol, Racepinephrine, and Ritod. Although minor, they should be discussed with a healthcare professional to ensure safe & effective use of medications.

[Note: This list might not include all potential interactions, as there could be other medications that interact with Asmanex. It’s crucial to adhere closely to your doctor’s guidance and ensure you have your quick-relief inhaler on hand for sudden asthma symptoms.]

Asmanex Twisthaler Alternatives

[Note: Your doctor will choose the best option tailored to your needs. Make sure to consult your healthcare provider before exploring any alternative medications, as using them without professional guidance could result in serious side effects.] 

Frequently Asked Questions

Is Asmanex a steroid?

Asmanex (mometasone) is a steroid-based inhaler prescribed for adults & children aged 4 and older to manage asthma. It reduces lung inflammation and maintains open airways, contributing to better breathing over time. However, it’s important to note that Asmanex is not designed for immediate relief during an asthma attack. It cannot substitute a rescue inhaler for sudden symptoms.

What are the benefits of Asmanex?

Asmanex contains mometasone furoate, a corticosteroid that inhibits the release of inflammation-causing substances in the body. It is primarily used for the prevention of asthma attacks. However, it is important to note that Asmanex is not suitable for treating an asthma attack that is already in progress.

Can Asmanex cause weight gain?

If you use a high dose of mometasone over an extended period (more than a few months), there is an increased risk of experiencing severe side effects. It’s important to consult a doctor if you notice symptoms such as “moon face” (a swollen, rounded face) or if you gain weight around your upper back and abdomen. These changes can occur gradually and may indicate Cushing’s syndrome, a condition that requires medical attention.

Can I take Asmanex twice a day?

Adults and children aged 12 & older should take two puffs of mometasone twice daily, once in the morning and once in the evening. Each puff delivers either 100 or 200 micrograms (mcg) of the medication. Depending on your needs, your doctor might adjust your dosage. Typically, the daily dosage of this medication should not exceed 400 to 800 mcg.

How do you inhale Asmanex?

To properly inhale Asmanex, begin by placing the mouthpiece securely between your lips, ensuring it is not obstructed by your teeth or tongue. Once in place, press down firmly on the top of the canister, ensuring a complete depression. Concurrently, take a deep and slow breath through your mouth. This method ensures that you receive the full dosage of the medication as it is designed to be delivered directly into the lungs.

How long does it take for Asmanex Twisthaler to work?

The onset of Asmanex Twisthaler’s effectiveness varies among individuals. Relief may take 24 hours for some, while others might experience maximum benefits after one to two weeks or more. Your doctor will provide guidance on the duration of Asmanex Twisthaler usage tailored to your condition.

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