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Amoxil (amoxicillin) is a widely used antibiotic that effectively treats a variety of bacterial infections, such as those affecting the respiratory and urinary tracts, as well as skin infections and Helicobacter pylori-related stomach ulcers. It comes in several forms and strengths, catering to both adults and children. While generally well-tolerated, common side effects include nausea and diarrhea. Severe allergic reactions are rare. Patients should follow their prescribed dosage regimen, complete the entire treatment course, and store the medication correctly. Those allergic to penicillin should seek medical advice before taking Amoxil.

Product Overview

Amoxil (amoxicillin) is an antibiotic used to treat a wide range of bacterial infections, including upper and lower respiratory tract infections, urinary tract infections (UTIs), skin infections, and Helicobacter pylori infections associated with stomach ulcers. As the main ingredient, amoxicillin works by inhibiting the growth of bacteria, targeting their cell wall synthesis, which is crucial for their survival.

Amoxil comes in various strengths and forms, including oral solutions, capsules, tablets, and chewable tablets. It is prescribed for both adults and children, with dosages adjusted based on age, weight, and the severity of the infection. The medication starts to work quickly, usually within 2 to 3 days and is effective against a broad spectrum of bacteria.

Common side effects of Amoxil include nausea, vomiting, diarrhea, stomach pain, headache, rash, and itching. Serious side effects, though rare, can include hypersensitivity reactions, liver damage, and severe skin reactions. Patients should take Amoxil exactly as prescribed, complete the full course of treatment, and store the medication at room temperature, away from light and moisture. It is essential to follow precautions, such as avoiding the medication if allergic to penicillin antibiotics and consulting a healthcare provider in case of missed doses, overdose, or interactions with other medicines.

Uses of Amoxil

  • Upper Respiratory Tract Infections: Infections of the ear, nose, and throat.
  • Lower Respiratory Tract Infections: Conditions such as pneumonia and bronchitis.
  • Urinary Tract Infections (UTIs): Infections affecting the urinary system.
  • Skin Infections like cellulitis.
  • Helicobacter pylori Infection: Affects adults only and is associated with stomach ulcers.

How to Use Amoxil?


Strengths and Forms

  • Oral solution: 125mg/5mL, 200mg/5mL, 250mg/5mL, 400mg/5mL
  • Capsule: 250mg, 500mg
  • Tablet: 500mg, 875mg
  • Tablet, chewable: 125mg, 250mg

Recommended Dosage for Different Patients

For mild or moderate upper respiratory tract infections, skin infections, and urinary tract infections (UTIs):

  • Adults and children aged 3 months and older who weigh at least 88 lbs (40 kg): The usual dose is 500 mg taken orally every 12 hours or 250 mg every 8 hours.
  • Children aged 3 months and older who weigh less than 88 lbs (40 kg): The usual dose is 12.5 mg/kg of body weight taken orally every 12 hours or 6.7 mg/kg every 8 hours.
  • Children younger than 3 months: The usual dose is up to 15 mg/kg taken orally every 12 hours.

For lower respiratory tract infections and other severe infections:

  • Adults and children aged 3 months and older who weigh at least 88 lbs (40 kg): The usual dose is 500 mg taken orally every 8 hours or 875 mg every 12 hours.
  • Children aged 3 months and older who weigh less than 88 lbs (40 kg): The usual dose is 13.3 mg/kg of body weight taken orally every 8 hours or 22.5 mg/kg every 12 hours.
  • Children younger than 3 months: The usual dose is up to 15 mg/kg taken orally every 12 hours.

For H. pylori infection (adults only):

  • Triple therapy: The usual dose is 1 gram taken orally every 12 hours for 14 days, in combination with clarithromycin and lansoprazole (Prevacid).
  • Dual therapy: The usual dose is 1 gram taken orally every 8 hours for 14 days, in combination with lansoprazole (Prevacid).

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • Take Amoxil exactly as prescribed by your healthcare provider. Do not take more or less than the recommended dose.
  • Take Amoxil at evenly spaced intervals to maintain a consistent level of the medication in your body. For example, if you’re instructed to take it every 8 hours, try to take it at the same times each day.
  • You can take Amoxil with or without food. However, taking it with food may help reduce stomach upset.
  • If you are taking Amoxil in capsule form, swallow the capsules whole with a full glass of water. Do not crush or chew the capsules.
  • If you are taking Amoxil as a liquid suspension, shake the bottle well before each use to ensure the medication is evenly mixed.
  • Use a measuring spoon or syringe to measure the correct dose of the liquid suspension. Do not use a regular household spoon, as it may not provide an accurate measurement.
  • Even if you feel better, complete the entire prescribed course of Amoxil to ensure that the infection is fully treated and to prevent the development of antibiotic-resistant bacteria.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Amoxil Work?

Amoxil (amoxicillin) works by inhibiting the growth of bacteria. It targets the bacterial cell wall, preventing the bacteria from forming a proper structure, which is essential for their survival. This disruption in the cell wall synthesis leads to the weakening and eventual bursting of the bacterial cells, effectively killing the bacteria and treating the infection. Amoxil is effective against a wide range of bacteria, making it a commonly used antibiotic.

Important Safety Information

Side Effects

Common side effects may include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Headache
  • Rash
  • Itching
  • White patches in the mouth or throat (oral thrush)
  • Vaginal yeast infection

Serious side effects may include:

  • Hypersensitivity reactions: These can manifest as flu-like symptoms (fever, body aches, sore throat), a painful red or purple rash that spreads, and blisters that can lead to open sores.
  • Liver damage: Although rare, symptoms can include elevated liver enzymes on blood tests, abdominal pain, yellowing of the skin and eyes, and fatigue.
  • Serious skin reaction: This rare side effect can present with flu-like symptoms (fever, body aches, sore throat), a skin rash with discoloration, swollen lymph nodes, and itchiness.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • Amoxicillin can cause severe allergic reactions, with symptoms including trouble breathing and swelling of the throat or tongue.
  • Amoxicillin increases the risk of developing a severe rash.
  • Amoxicillin may cause false-positive results when testing for glucose in the urine. Discuss blood sugar management with your doctor while taking amoxicillin.
  • If you have severe kidney disease, your body may not clear amoxicillin quickly, leading to buildup. Your doctor may prescribe a lower dose to prevent this.


  • Do not use Amoxil if you are allergic to amoxicillin or any other penicillin antibiotics such as ampicillin, dicloxacillin, oxacillin, or penicillin.
  • Inform your doctor if you are allergic to cephalosporins like Omnicef, Cefzil, Ceftin, or Keflex, or if you have issues like asthma, liver or any kidney disease, a bleeding or blood clotting disorder, mononucleosis, or any type of allergy.
  • Amoxil can reduce the effectiveness of birth control pills. Discuss alternative non-hormonal birth control methods with your doctor while taking this medication.
  • Complete the full prescribed course of Amoxil, even if your symptoms improve before the infection is fully cleared.
  • Amoxil is not effective against viral infections such as the common cold or flu.
  • Do not share Amoxil with others, even if they have similar symptoms.
  • Amoxil can cause diarrhea. If you experience watery or bloody diarrhea, stop taking the medication and contact your doctor immediately.
  • Avoid using anti-diarrhea medicine unless directed by your doctor.


Amoxil should not be used by patients who have had a severe allergic reaction, such as anaphylaxis or Stevens-Johnson syndrome, to Amoxil or other β-lactam antibiotics, including penicillins and cephalosporins.

Missed Dose

If you forget to take your dose, take it at the earliest moment possible; however, if it’s just a few hours before your next scheduled dose, only take one dose. Do not take two doses at once to catch up, as this could lead to harmful side effects.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]


In case of an overdose, there may be dangerous levels of the drug in your body. Symptoms of an overdose are typically not significant if less than 250 mg/kg. However, in cases of higher doses, it may lead to kidney failure.

[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]


  • Keep amoxicillin at room temperature, between 59°F and 86°F (15°C and 30°C). 
  • Protect the medication from light and avoid storing it in moist or damp places, like bathrooms.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Amoxil Interactions

  • Methotrexate: This medication can increase the toxicity of methotrexate, a medication used to treat cancer and autoimmune diseases.
  • Allopurinol: Taking amoxicillin with allopurinol, a medication used to treat gout, can increase the risk of developing a skin rash.
  • Birth Control Pills: Amoxicillin can decrease the effectiveness of birth control pills, increasing the risk of unintended pregnancy.
  • Warfarin: It enhances the effects of warfarin, an anticoagulant, potentially increasing the risk of bleeding.
  • Probenecid: This medication, used to treat gout, can increase the levels of amoxicillin in the blood, potentially leading to increased side effects.
  • Antibiotics: Using amoxicillin with other antibiotics can sometimes lead to decreased effectiveness or increased side effects.
  • Live Bacterial Vaccines: Amoxicillin can reduce the effectiveness of live bacterial vaccines, such as the typhoid vaccine.

[Note: This isn’t a complete list, and there could be other drugs that interact with Amoxil. Make sure to tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Amoxil Alternatives

  • Augmentin (amoxicillin/clavulanate)
  • Zithromax (azithromycin)
  • Keflex (cephalexin)
  • Omnicef (cefdinir)
  • Cipro (ciprofloxacin)
  • Levaquin (levofloxacin)
  • Bactrim (sulfamethoxazole/trimethoprim)
  • Doxycycline (doxycycline)
  • Cleocin (clindamycin)
  • Factive (gemifloxacin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Quick Tips

Frequently Asked Questions

Is Amoxil a strong antibiotic?

Amoxil, also known as Amoxicillin, is a powerful antibiotic. It works well because it can fight against many different types of bacteria. This includes bacteria that cause common infections like E. coli, salmonella, and strep throat, as well as some less common ones. That’s why doctors often choose it to treat various bacterial infections.

Is Amoxil a type of penicillin?

Yes, amoxicillin (Amoxil) is a type of penicillin antibiotic. If you have a penicillin allergy, you may also be allergic to amoxicillin (Amoxil). Your healthcare provider will consider your reaction to penicillin when deciding whether to prescribe amoxicillin (Amoxil) for your infection. If you had a mild reaction like a rash or itchy skin with penicillin, your provider may still prescribe amoxicillin (Amoxil) and ask you to monitor for allergic reactions. However, if you had a severe reaction such as facial swelling, throat closure, or anaphylaxis, your provider might choose a different antibiotic to ensure your safety.

How quickly does Amoxil start working, and how long does it stay in the body?

Amoxicillin (Amoxil) begins to work rapidly, with most people starting to feel better after 2 to 3 days of treatment. As for how long amoxicillin (Amoxil) remains in the body, it typically lasts up to 8 hours after a single dose before most of the medication is eliminated. However, this duration can vary depending on the dosage and the health of your kidneys. Since the kidneys play a key role in excreting the medication, individuals with kidney problems may experience a slower clearance of the drug from their bodies.

Can Amoxil cause diarrhea?

Yes, diarrhea is a frequent side effect of antibiotics like amoxicillin (Amoxil). If you experience diarrhea, consider following the BRAT diet temporarily to ease your stomach upset or using over-the-counter diarrhea medications. However, if you develop watery or bloody diarrhea, fever, fatigue, or stomach cramps during or after treatment with amoxicillin (Amoxil), contact your healthcare provider immediately. These symptoms could indicate a severe infectious diarrhea that requires medical attention.

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