Amlodipine Besilate

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Amlodipine is available as both a generic and brand-name drug. This FDA-approved medication is indicated for treating hypertension, chest pain, and coronary artery disease. It can only be used with a doctor’s prescription. This prescription drug is suitable for both adults and children ages six years of age and above, but its dosage may vary based on the severity of the condition and the body needs of the patients. Overlooking the dosage range can result in serious complications. Therefore, always follow your doctor’s instructions to avoid such conditions.

Product Overview 

Amlodipine is a highly effective medication primarily used to treat high blood pressure or hypertension and chest pain or angina. It contains the active ingredient amlodipine besylate, a calcium channel blocker that relaxes and expands blood vessels, allowing for better blood flow. This FDA-approved prescription drug is widely recognized for its ability to manage hypertension and reduce the risk of heart attacks and strokes.

Amlodipine is available in tablet form in strengths of 2.5, 5, and 10 mg. It is typically taken once daily, with or without food, and should be swallowed whole with a glass of water. Adults and children aged six years and older can take it, but a healthcare professional should always direct dosage and usage. 

Common side effects include dizziness, swelling of the ankles or feet, and fatigue. If severe side effects occur, such as irregular heartbeat or severe abdominal pain, seek medical attention immediately. It is essential to follow your healthcare practitioner’s advice and not to stop taking the medication suddenly. 

Uses of Amlodipine

It is used to treat the following conditions:

• Hypertension, also known as high blood pressure
• Heart diseases, including coronary heart diseases
• Angina (a type of chest paiin)

Benefits of Amlodipine

The medication has various benefits, which are as follows:

• Amlodipine helps in reducing high blood pressure, thus minimizing the risk of heart attacks & strokes.
• It aids in relieving chest pain by improving blood flow to the heart.
• Amlodipine improves exercise tolerance by reducing chest pain during physical activity.
• It helps in reducing the workload on the heart by relaxing blood vessels.
• This medication is effective in treating coronary artery disease.

Side Effects of Amlodipine

Common side effects of Amlodipine may include:

• Nausea
• Headache
• Abdominal pain
• Flushing
• Dizziness
• Palpitations
• Edema
• Muscle cramp
• Visual disturbance
• Shortness of breath
• Change in bowel movements
• Weakness
• Sleepiness

[Note: This list is not exhaustive; if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]

Amlodipine Dosage

Forms & Strengths

Amlodipine is available in an oral tablet form with the following strengths:

• 2.5 mg
• 5 mg, and
• 10 mg

Recommended Dosages

Dosage for Hypertension

For Adults

• The typical starting dose of this medication is 2.5 mg once daily.
• After 7 to 14 days of the treatment, your doctor may adjust the dosage if your blood pressure levels are not managed.
• The maximum daily dose for adults is 10 mg.

For Children (6 to 17 Years)

• The recommended dose of Amlopidine for children is 2.5 to 5 mg, taken once a day. 
• The maximum daily-dose of Amlodipine is 5 mg. Doses above the mentioned mg have not been studied for use in this age group.

For Children Below 5 Years

• The safety and effectiveness of this medication have not been determined for use in this age group.

For Older Patients (65 Years and Above)

• The usual prescribed dose is 2.5 mg once a day.
• Doctors usually prescribe a lower dosage range to senior patients as they process the drugs much slower than young adults, leading to drug buildup in their bodies.

Dosage for Coronary Artery Disease and Chest Pain

For Adults

• Doctors usually prescribe 5 mg of Amlodipine, which is taken once a day.
• The maximum daily-dose of this medication is 10 mg each day.

For Children (0 to 17 Years)

• This medication is not suitable for use in children.

For Senior Patients (65 Years and Above)

• The typical prescribed dosage is 5 mg, taken once daily.
• Doctors usually prescribe a lower dosage range to senior patients as they process the drugs much slower than young adults, leading to drug buildup in their bodies.

How to Take Amlodipine?

• Read the patient information leaflet thoroughly to ensure you are not missing out on any administration steps.
• Follow the dosage instructions as your healthcare provider provides them.
• Take the medication by mouth, usually with or without food or as directed by your medical provider.
• Swallow the tablets with a glass of water unless instructed otherwise.
• Do not crush, chew, split, or break the medication, as it will release the drug all at once.
• You can take the medication by mixing it with water, but drink it immediately.
• If you are unable to swallow the tablets, talk to a medical professional. They will suggest alternate options or recommend other treatments.
• Avoid drinking grapefruit juice with your medication. Large amounts of grapefruit and its juice can increase the drug buildup, thus worsening the side effects. 

Missed Dose 

• If you have mistakenly forgotten a dose of your medication, take it as soon as possible.
• If it is almost time for the next dose, continue following your usual dosing schedule and skip the missed dose.
• Do not take a double dose simultaneously to catch up on the missed one.
• Take each medication at the same time regularly for effective results.
• Use medication apps or set reminders to avoid skipping any doses.

[Note: Do not take two doses of Amlodipine at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]

Overdose

If someone has taken too much Amlodipine and is experiencing overdose symptoms like rapid heartbeats, passing out, and redness in the arms or legs, get medical assistance immediately by calling 911.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Amlodipine Work?

Amlodipine works by restricting calcium channels in the muscle cells of the heart & blood vessels. This action relaxes and expands the blood vessels, allowing blood to flow seamlessly and lowering blood pressure. Amlodipine effectively treats high blood pressure and angina by decreasing the heart’s workload and improving the oxygen supply to the heart muscle. This mechanism helps prevent heart attacks and strokes, promoting overall cardiovascular health.

Important Safety Precautions

• Before starting treatment with Amlodipine, inform your doctor if you are allergic to any of the ingredients. 
• The liver processes Amlopidine, so if your liver is not functioning properly, the drug will remain in the body for a prolonged period. This may result in an increased risk of side effects. Therefore, if you have severe liver problems, talk to a medical professional. They will adjust your dosage accordingly.
• Patients with severe aortic stenosis have one narrowed heart valve, limiting the blood flow to the body. If you have such a medical condition and are taking Amlodipine, you may experience low blood pressure. 
• Severe obstructive coronary artery disease narrows the arteries, which restricts the blood flow and increases the risk of problems like heart attack or chest pain. Patients with such conditions should talk to a healthcare provider. They will prescribe you a low dosage and closely monitor for any unusual signs.
• If you are pregnant or a lactating woman, talk to your doctor before taking this medication.  

Storage 

• Keep the drug stored at a temperature of 15°C to 30°C.
• Keep it away from children and pets.
• Avoid keeping the medication in moist or damp areas like the bathroom.
• Read the product’s labels carefully for detailed storage instructions.
• Do not keep it under direct sunlight.
• Discard the product when not in use.
• Do not flush the medication down the toilet.

Amlodipine Interactions

• Apalutamide
• Apomorphine
• Carbamazepine
• Ceritinib
• Dolasetron
• Encorafenib
• Lemborexant
• Lonafarnib
• Mitotane
• Rifabutin
• Rifampin
• Simvastatin

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Amlodipine Alternatives

• Atenolol
• Carvedilol
• Losartan
• Hydrochlorothiazide
• ACE inhibitor
• Felodipine

[Note: Your healthcare provider will choose which Amlodipine alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions 

Can I take Amlodipine for the long term?

Yes, Amlodipine is often prescribed for long-term use to manage high blood pressure and prevent chest pain. It can be used for the rest of your life. Regular monitoring by a healthcare provider ensures its continued effectiveness and safety for prolonged treatment.

Is Amlodipine a high-risk medication?

Amlodipine is generally considered safe when taken as prescribed. While not classified as high-risk, it can cause side effects and interactions, so it should be used under medical supervision, especially in individuals with certain health conditions.

What happens if I suddenly stop using Amlodipine?

Stopping Amlodipine suddenly can lead to a rapid increase in blood pressure and the return of chest pain. Therefore, it is important to follow your doctor’s guidance to discontinue the medication gradually to avoid adverse effects.

When is the best time to take Amlodipine?

Amlodipine can be taken at any time of day, but it is best to take it at the same time each day to maintain consistent blood levels. Follow your healthcare provider’s instructions for the optimal dosing schedule.

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