Tacrolimus

Buy Advagraf Online

Advagraf is a prescription medication that prevents organ rejection in transplant patients. This drug can be used with other medicines to effectively protect the transplanted organs from attack. Each patient’s dosage recommendations may vary based on their type of transplant, body weight, and the usage of other medications. Organ transplantation is not a common medical condition; therefore, patients need to understand the importance of taking their medicines on time. It is important for individuals to inform their healthcare practitioner about their medical history to prevent any serious complications in the future.  

Product Overview

Advagraf is an extended-release immunosuppressive medication containing the active ingredient Tacrolimus. It is widely used to prevent organ rejection in kidney and liver transplant patients. This medication is FDA-approved and available by prescription only. It effectively suppresses the immune system to protect transplanted organs from being attacked.

Advagraf is available in capsule form and comes in various strengths to allow for customized dosing based on individual patient needs. It is typically taken once daily, providing stable blood levels and reducing the chances of adverse effects. Suitable for adult transplant patients, the medication works by restricting the activity of immune cells that can cause organ rejection.

While Advagraf is generally well-tolerated, some patients may experience side effects like headaches, gastrointestinal issues, or increased susceptibility to infections. So, it is important to follow your practitioner’s instructions carefully, including what to do if a dose is missed or in case of an overdose. Regular monitoring by a medical professional is essential to ensure the medication’s efficacy and safety.

Uses of Advagraf 

It is used to prevent organ rejection in transplant patients.

Benefits of Advagraf

Here are some of the benefits of Advagraf:

• It is highly effective in preventing organ rejection in patients with kidney or liver transplants.
• Advagraf weakens the immune system, which is responsible for fighting infections. As a result, it minimizes the risk of the body attacking the transplanted organ.
• Long-term use of this medication can enhance transplanted organs’ overall success and longevity.
• It is available in various strengths, allowing patients to take doses according to their needs.

Side Effects of Advagraf 

Common Advagraf side effects may include:

• Nausea 
• Diarrhea
• Kidney problems
• Tremor 
• Headache
• Hyperglycemia (high blood glucose levels)
• Hyperkalemia (high blood potassium levels)
• Hypertension (high blood pressure)
• Insomnia 
• Unstable liver function tests

[Note: This list is not exhaustive; if you notice any other symptoms that are not mentioned above, consult your doctor immediately.]

Advagraf Dosage

Forms & Strengths

It is available in the form of prolonged-release hard capsules with the following strengths:

• 0.5 mg
• 1 mg
• 3 mg, and
• 5 mg

Recommended Dosages

Dosage for Kidney Transplant Patients

• 0.1 to 0.2 mg once daily, divided into two doses. Start using this medication within 24 hours of the transplant. 
• Doctors may adjust the dosage based on the clinical assessments and blood level. This will minimize the chances of potential side effects while preventing organ rejection.

Dosage for Liver Transplant Patients

• 0.1 to 0.15 mg once daily, divided into two doses. Start using this medication within 12 to 18 hours after the transplant. 
• The dosage will be adjusted on the basis of the patient’s response and blood tacrolimus levels.

Dosage for Heart Transplant Patients

• 0.075 mg once daily, divided into two doses. Start using this medication within 5 days of the transplant. 
• Your medical provider may adjust your dose based on the monitoring of clinical response and drug level.

Dosage for Pediatric Patients

• The doses are mostly similar to the adult’s dosage, but doctors usually adjust children’s doses more frequently due to differences in their drug metabolism.
• Children’s dose adjustments are based on their body weight, medical condition, and blood drug levels.

How to Take Advagraf?

• Before taking this medication, make sure to read the medication guide for detailed information.
• Take the capsules by mouth with a glass of water or as your healthcare provider instructed you to do so.
• Swallow the medication as a whole. 
• Do not break, chew, split, or crush the medication.
• If you are unable to swallow the medication, ask your healthcare provider. They will surely suggest some alternate options.
• Take the medication at least 1 hour before your meal. 
• Do not change or alter the doses without consulting your medical practitioner.
• Keep taking your capsules in time so that your body does not reject the transplanted liver, kidney, or heart.
• Take your medication regularly at the same time to get the most benefit out of it.

Missed Dose 

• If you forget to take your medication, do not panic. Take it as soon as possible or whenever you remember.
• If it is almost time for the next dose, you may omit the missed dose and continue your regular dosing schedule.
• Do not take double doses of Advagraf simultaneously to catch up for the missed dose.
• Use medication apps or set reminders to avoid skipping any doses.

[Note: Do not take two doses of Advagraf at the same time to compensate for a missed dose. This can increase your risk of experiencing side effects.]

Overdose

Generally, patients are advised not to take an exceeding amount of the maximum daily dose, but if someone has mistakenly taken an overdose of Advagraf, they may experience unusual symptoms like:

• Tremors
• Nausea
• Headache
• Skin allergies
• Changes in enzyme levels such as creatinine or blood urea nitrogen

If you notice any of the above-mentioned Advagraf overdose symptoms, you should immediately contact your medical provider or call 911.

[Note: If you notice you have taken too much medication, call your local emergency number immediately.]

How Does Advagraf Work?

Advagraf (Tacrolimus) works by suppressing the immune system to prevent it from attacking a transplanted organ. It specifically slows down the activity of T-lymphocytes, a white blood cell type active in the immune response. By reducing T-lymphocyte activity, Advagraf helps prevent organ rejection, ensuring the transplanted organ can function properly and be accepted by the body. Its extended-release formulation provides stable blood levels of the medication, allowing for consistent immunosuppression with once-daily dosing.

Important Safety Precautions 

• Before you start taking this medication, inform your medical professional if you are allergic to Advagraf or any of its ingredients. The product may contain certain inactive components that can cause allergic reactions. 
• If you are undergoing surgery or any medical procedure, tell your healthcare provider about the products you use. This includes prescription drugs, nonprescription drugs, and herbal products.
• This medication suppresses the immune system, which can increase the risk of infection in patients. So, if you are taking Advagraf, monitor for any signs of infections like sore throat or fever.
• Advagraf may affect kidney function. Therefore, if you are taking this medication, you should have frequent blood tests to check if your kidneys are functioning properly.
• If you are experiencing severe diarrhea that lasts more than a day, immediately talk to your medical professional.
• If you are planning to get a vaccination, inform your doctor beforehand. Some vaccines may not be ideal companions for immunosuppressant medications.
• In the initial days of your treatment with Advagraf, you must take various routine tests, including blood, heart function, and urine. Doing so will determine the suitable dose for your condition.

Storage

• Store Advagraf capsules under 30°C.
• Keep the medication away from heat and moisture sources.
• Do not flush the medication down the toilet.
• Keep them somewhere safe and away from children’s reach and sight.
• Do not store the product in damp places like the bathroom or the sink.
• Discard the medication if it has reached its expiration date.
• Ask a medical provider or pharmacist how to dispose of the medication properly without damaging the environment.

Advagraf Interactions

Some of the Advagraf drug interactions are:

• Ketoconazole
• Voriconazolefluconazole
• Itraconazole
• Erythromycin
• Clarithromycin
• Rifampin
• Phenytoin
• Phenobarbital
• Carbamazepine
• St. John’s Wort
• Sirolimus
• Cyclosporine

[Note: This list of interactions isn’t complete. Talk to your doctor if you notice any interaction with food, over-the-counter drugs, prescriptions, or supplements.]

Advagraf Alternatives

• Tacni (tacrolimus)
• Tacrograf (tacrolimus)
• Pangraf (tacrolimus)
• Envarsus XR (tacrolimus extended-release)
• Astagraf XL (tacrolimus extended-release)
• Prograf (tacrolimus)

[Note: Your healthcare provider will choose which Advagraf alternative is best for you. Taking or consuming them by yourself may cause serious side effects.] 

Frequently Asked Questions 

What are the serious side effects of Advagraf?

Serious side effects of Advagraf can include:

• High blood pressure.
• Kidney problems.
• Liver damage.
• Increased risk of infections.
• Increased risk of developing certain cancers.

If you experience symptoms like severe headaches, changes in urine output, jaundice, or unexplained infections, contact your medical practitioner immediately for evaluation and appropriate management.

Who should not use Advagraf?

Advagraf should not be used by individuals who have:

• Allergies to Tacrolimus or any of its components. 
• Severe kidney or liver problems
• Those who have had allergic reactions to similar medications. 

Lastly, pregnant or breastfeeding patients should consult their healthcare provider before using Advagraf.

Can I drink alcohol while taking Advagraf?

It is generally advised to avoid alcohol while taking Advagraf, as alcohol can increase the risk of liver damage and exacerbate side effects. Consult your medical practitioner for personalized advice regarding alcohol consumption while on Advagraf, as individual health conditions may vary.

Is Advagraf a steroid?

No, Advagraf is not a steroid. It is an immunosuppressant medication containing Tacrolimus, which helps prevent organ rejection after a transplant by restricting the activity of certain immune cells. Unlike steroids, which have a broader range of effects, Advagraf specifically targets the immune response involved in transplant rejection.

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