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Acyclovir Cream 

Acyclovir Cream offers effective treatment against herpes simplex virus outbreaks, including cold sores and genital herpes. The cream’s active ingredient, Acyclovir, targets the viral DNA to prevent the virus from multiplying, thereby reducing symptoms and healing time. This medication is suitable for adults and adolescents over 12; it is applied five times daily to the affected areas. While generally considered safe, users should be aware of possible side effects like skin irritation and seek immediate help for any severe reactions. Always consult a healthcare provider before beginning treatment with Acyclovir Cream to ensure it is appropriate for your specific condition.

Product Overview

Applied topically, Acyclovir Cream is an antiviral medication mainly used to treat herpes simplex virus infections, including cold sores and mild herpes infections. It contains Acyclovir as its main active ingredient, which effectively manages outbreaks by inhibiting viral DNA replication. This action helps reduce the duration and severity of herpes symptoms. Acyclovir Cream is FDA-approved for these indications; it ensures the safety and efficacy of medication when used as directed. The cream penetrates the skin to reach infected cells, interfering with viral enzymes and halting the virus’s ability to multiply.

The product comes in a 5% strength formulation intended for topical application. To use, adults and adolescents aged 12 and older should apply a thin layer of the cream to the affected area five times a day, every four hours, excluding sleep hours, for up to 10 days if symptoms persist. While the cream is generally safe for most users, it is not recommended for children under 12 unless advised by a healthcare provider. Elderly patients and those with renal impairment do not require dosage adjustments but should consult their doctors to ensure safe use.

Acyclovir Cream may cause side effects such as skin irritation, dryness, and itching. Serious reactions like allergic responses, swelling of the face, or difficulty breathing require immediate medical attention. It should be stored below 25°C (77°F) and not used past its expiration date. Patients should follow their healthcare provider’s instructions regarding missed doses and avoid doubling doses. Additionally, precautions should be taken to avoid spreading the infection to others and to prevent drug interactions by discussing all current medications with a healthcare provider.

Uses of Acyclovir Cream 

  • Treats cold sores/fever blisters (Herpes Labialis)
  • Genital herpes infection
  • Mild herpes simplex infections

How to Use Acyclovir Cream?


Form: Topical application

Strength: 5%

Form: topical ointment

Strength: 5%

Form: mucoadhesive buccal tablet

Strength: 50mg (Sitavig)

Recommended Dosage for Different Patients

Adults and Adolescents (Aged 12 years and older)

  • Apply a thin layer of the cream to the affected area five times a day, approximately every four hours, excluding the time spent sleeping. Continue treatment for 4 days. If the infection has not improved after 4 days, the treatment may continue for up to 10 days.

Children (under 12 years old)

  • Use of Acyclovir Cream 5% in children under 12 is not typically recommended unless advised by a healthcare provider.

Elderly Patients

  • The dosage for elderly patients is generally the same as for adults. However, because elderly patients have more chances of reduced renal function thus, care should be taken in dose selection.

Patients with Renal Impairment

  • No adjustment of dosage is necessary as the cream is topically administered. However, consulting a healthcare provider is suggested to ensure safety.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • Wash your hands: Make sure your hands are clean before applying the cream.
  • Clean the affected area: Gently clean and dry the area of skin to apply the cream.
  • Application: Apply a thin layer of the cream covering the skin where the cold sore has formed or seems likely to form.
  • Rub it gently: Massage the cream into the skin until it disappears.
  • Leave the skin uncovered: Do not cover the area with plastic or waterproof bandages unless instructed by your doctor.

[Note: Your medical expert will decide the right amount for you as per your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Acyclovir Cream Work?

Acyclovir Cream functions by inhibiting the replication of certain viruses, particularly herpes simplex viruses (HSV-1 and HSV-2). It belongs to a class of medications known as antiviral drugs. When applied topically, Acyclovir penetrates the skin and enters infected cells, blocking the action of viral enzymes required for DNA synthesis. By interfering with viral DNA replication, Acyclovir reduces the spread and severity of herpes infections, helping to alleviate symptoms such as cold sores or genital herpes lesions.

Important Safety Information

Side Effects

Common Side Effects

  • Skin irritation
  • Burning or stinging
  • Dry skin
  • Itching
  • Dry lips

Adverse/Serious Side Effects

  • Allergic Reaction: Possible symptoms of allergy arm rash, hives, itching, redness, blistering, or peeling skin, which may occur with or without fever. Other symptoms include difficulty breathing or swelling of the face, mouth, tongue, or throat. These symptoms require immediate medical attention.
  • Swollen Face/Eyes/Lips/Tongue: Sudden swelling in these areas should be treated as a medical emergency.
  • Difficulty Breathing: If you experience trouble breathing, seek urgent medical help.
  • Itchy Skin Rashes: Extensive, itchy skin rashes should be evaluated by a healthcare provider.
  • Elevated Blood Pressure, Hypotension, or Bradycardia: Those with hypertension, heart rate or conduction disorders, or taking medications that cause bradycardia may have an increased risk of these cardiovascular effects.

[Note: The above list does not cover all possible side effects. Always consult with your healthcare specialist for medical advice about side effects.]


  • Risk of Resistance: Prolonged or repeated use of Acyclovir Cream may result in the development of resistance. It is important to use the cream only as prescribed by a healthcare provider.
  • Cross-Contamination: To prevent spreading the infection to other parts of the body or other people, avoid touching the affected area and then touching other areas or individuals.
  • Not for Oral, Intravaginal, or Ophthalmic Use: Acyclovir Cream is intended for external use only on skin lesions. It should not be used orally, inside the vagina, or in the eyes.
  • Drug Interactions: Inform your medical professional about all the medications you are taking, including over-the-counter drugs and herbal products, to avoid potential drug interactions.
  • Underlying Health Conditions: Patients with certain underlying health conditions may experience more severe side effects. Those with a history of kidney problems or a compromised immune system should use this cream under close medical supervision.
  • Treatment of Mucous Membranes: Acyclovir Cream is not recommended for application on mucous membranes such as in the mouth, nose, or genital sores, as its safety and efficacy in these areas have not been established.


  • Inform your medical professional if you’re allergic to acyclovir, valacyclovir, or any other substances in the medication. Inactive ingredients like polyethylene glycol may trigger allergic reactions or other issues.
  • Before using this medication, disclose your medical history to your doctor or pharmacist.
  • Before surgery, inform your medical specialist about all medications you’re using, including prescription, over-the-counter, and herbal products.
  • Cold sores are contagious. Avoid close contact, like kissing during an outbreak, until they’re fully healed. Also, avoid touching the cold sore directly. Wash your hands right away if you touch it.
  • Take these measures to reduce the risk of transmitting genital herpes to your partner:
    • Refrain from sexual contact during an outbreak or when experiencing symptoms.
    • Even without symptoms, genital herpes can still spread.
    • Always use effective barrier methods (like latex or polyurethane condoms/dental dams) during sexual activity. Consult your doctor or pharmacist for more guidance.
  • Notify your doctor if you’re pregnant before using this medication. Discuss with your medical professional the potential risks and precautions you should undertake.
  • It’s unclear if this medication passes into breast milk. Consult your doctor before breastfeeding, especially if you have herpes sores on or near your breast. Avoid breastfeeding in such cases.

Missed Dose

If you miss a dose of Acyclovir Cream, apply it as soon as you remember it. However, if it is close to your next dose, leave the missed dosage and return to your regular schedule. Do not double the dose.

[Note: If you have missed using Acyclovir Cream at the suggested time and are unsure about the next one, then reach out to your doctor or pharmacist.]


Acyclovir Cream is applied to the skin to treat cold sores caused due to the herpes simplex virus. Overdosing on topical application of Acyclovir cream is unlikely due to minimal systemic exposure.

[Note: If you have used this medication more than you were recommended, get medical help immediately or call the Poison Help line at 1-800-222-1222.]


  • Store below 25°C (77°F).
  • Do not refrigerate or freeze the cream.
  • Do not use Acyclovir cream post the expiry date as stated on the carton and the tube.

[Note: Discuss with your medical professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Acyclovir Cream Interactions

  • Other Topical Medications:
      • Using other topical medications concurrently with Acyclovir Cream may increase the risk of interactions or decrease the effectiveness of either medication. Consult your healthcare expert before using multiple topical treatments.
  • Medications that Weaken the Immune System:
      • Drugs that suppress the operation of the immune system, such as corticosteroids or immunosuppressants, may affect the efficacy of Acyclovir Cream. Inform your doctor if you’re using medications that weaken your immune system.
  • Probenecid:
      • It is used to treat gout, which may increase the concentration of Acyclovir in the body, potentially causing higher levels of the medication and an increased risk of side effects. Your doctor may adjust your dosage if you’re taking Probenecid.
  • Nephrotoxic Drugs:
      • Drugs that can potentially harm the kidneys, like certain antibiotics or nonsteroidal anti-inflammatory drugs (NSAIDs), may increase the risk of kidney-related side effects when used concomitantly with Acyclovir Cream. Monitor for any signs of kidney problems if using these medications together.
  • Zidovudine (AZT):
      • Combining Acyclovir Cream with zidovudine, a medication used to treat HIV/AIDS, may increase the risk of side effects related to zidovudine. Your doctor may need to monitor you more closely if you’re using these medications together.
  • Interferon:
    • Interferon, a medication used to treat certain viral infections, may interact with Acyclovir Cream. Your medical professional must monitor your health condition closely if you’re using these medications concurrently.

[Note: This isn’t a complete list, and there could be other drugs that interact with Acyclovir Cream 5%. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Acyclovir Cream Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

How quickly does Acyclovir Cream start to work?

The effectiveness of Acyclovir and the time it takes to see improvement depends on multiple factors, including the type and severity of the infection and how soon treatment begins. Generally, Acyclovir is prescribed for a duration of 4 to 10 days. While symptoms may start to alleviate before the course of treatment is complete, it’s crucial to continue taking the medication for the full prescribed period. Stopping early may cause the infection to worsen. Consult your certified medical professional to understand more about the expected timeline for symptom improvement after starting Acyclovir.

Is it safe to consume alcohol while taking Acyclovir Cream?

There is limited information on interactions between alcohol and Acyclovir. It is suggested to consult your medical expert to determine if it is safe for you to consume alcohol while on this medication. Remember that excessive alcohol consumption can weaken the immune system, potentially making it more difficult for your body to combat infections.

Can Acyclovir Cream cure herpes?

Currently, there is no cure for herpes. Acyclovir is effective in treating herpes outbreaks as they occur, but it does not eliminate the virus from the body. As a result, the herpes virus can remain dormant and potentially result in future outbreaks.

Does Acyclovir Cream have an expiration date?

Yes, Acyclovir does expire. The manufacturer provides the expiration date of the cream and indicates the last date the medication is expected to maintain its full potency and safety. Over time, the chemical composition of the cream can alter, potentially reducing its effectiveness. While taking expired medication typically does not pose a direct health risk, there is a concern that it may not effectively treat your condition. If your Acyclovir has expired, it is advisable to dispose of it safely and consult your healthcare provider for a new prescription.

Our Guarantee

At, we assure you the most affordable price to buy Acyclovir Cream from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently access Acyclovir Cream at a substantial cost, call us at 1-888-779-2193 toll-free.


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