Insulin Aspart

Novomix

Novomix, an FDA-approved medication used to improve glycemic control in patients with diabetes mellitus, was developed and manufactured by Novo Nordisk. It contains insulin aspart and insulin aspart protamine. It has different strengths: NovoMix 30, NovoMix 50, and NovoMix 70. Do not use novomix if you have severe hypoglycemia or if you have an allergy to any of the ingredients present in the medication. It is crucial to follow the directions given by your doctor or healthcare provider for a safe and efficient use of the medication. Consult your doctor if you have any queries or concerns regarding the medication or its potential risks and benefits.

Product Overview

NovoMix is a versatile insulin product developed by Novo Nordisk that comprises insulin aspart and insulin aspart protamine. It is designed to treat type 1 and type 2 diabetes mellitus in children, adolescents, and adults. NovoMix offers rapid and consistent blood sugar control, reducing the risk of diabetes-related complications. It has different strengths: NovoMix 30, NovoMix 50, and NovoMix 70. NovoMix should be administered subcutaneously, with doses adjusted based on individual needs for practical use. 

Rotating injection sites to avoid skin issues and ensuring the insulin is at room temperature before use is crucial. Regular blood glucose monitoring is recommended to tailor the dosage accurately. Common side effects may include low blood sugar, injection site reactions, and weight gain. Patients should be cautious of hypoglycemia and seek immediate medical attention for severe side effects like severe hypoglycemia or allergic reactions. 

NovoMix should not be used in insulin pumps or mixed with other insulins. Proper storage is essential, with unopened vials kept in the refrigerator and opened vials at room temperature for up to four weeks. It is crucial to discard any unused or expired medication safely. Consult a healthcare professional for personalized advice and dosage adjustments.

Uses

Targeted Treatment 

It is used in children, adolescents and adults to treat type 1 and 2 diabetes mellitus.  

Benefits

• It reduces the chances of developing severe complications associated with diabetes.
• It ensures rapid and consistent sugar control throughout the day.

[Note: Do not take Novomix without consulting your doctor. They will determine whether you need this medication based on your conditions.]

Novomix Dosage

Forms & Strengths

Form: NovoMix 30

Strength: 30% insulin aspart and 70% insulin aspart protamine 

Form: NovoMix 50

Strength: 50% insulin aspart and 50% insulin aspart protamine

Form: NovoMix 70

Strength: 70% insulin aspart and 30% insulin aspart protamine

Recommended Dosages

Type 1 Diabetes Mellitus 

• Daily recommended dose: 0.5- 1.0 units/ kilogram of body weight daily. 
• To be administered once, twice or thrice daily. 

Type 2 Diabetes Mellitus

• Recommended starting dose: 6 units at breakfast and six units at the evening meal
• It is to be injected immediately before or after a meal if necessary.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

• Carefully read the patient leaflet that comes along with the prescription before using Novomix for the first time.
• Before using Novomic for the first time, your doctor will show you how to administer it properly. 
• Follow the directions given by your doctor for safe and effective use. 
• Ensure you have the correct type and dosage set on the product before use. 
• Do not reuse or share your insulin medications, such as pre-filled pens and syringes, with others, even if the needle is changed. It may cause infection to spread from one person to another. 
• Check your insulin for any unusual change in appearance. Do not use it if it appears discolored, clumpy or has particles in it. 
• Do not inject Novomix into a vein or muscle. It is meant for subcutaneous use only. 
• The best sites to inject the insulin are the abdomen, buttocks, upper arm, and front thighs.
• Constantly rotate the injection site to avoid lumps and pits forming under your skin. 
• Do not inject insulin into skin torn, damaged, red, swollen, or scars or stretch marks. 
• In use and opened, Novomix should be kept at room temperature. Do not inject cold insulin, as it may be painful. 
• Wash your hands before and after injecting the insulin. 
• Do not use the product if it is tampered with, damaged, broken, or leaking. 
• Do not shake the container. Gently roll the container between your hands at least ten times. 
• Gently mix the insulin until it looks evenly white and cloudy. If it does not appear this way, do not use it. Discard the medication and get a new one from your pharmacist. 
• Measure each dose very carefully, as even slight changes can cause adverse effects such as hyperglycemia and hypoglycemia.
• Before injecting each dose, clean the injection site with rubbing alcohol and a cotton swab and ensure that the spot is dry and clean.
• Inject the medication as instructed by your doctor, typically once or twice a day. 
• After use, discard the needles correctly. 
• Do not rub the injection spot after injecting. 
• Do not dilute or mix Novomix with other insulins and medications. 
• Do not use the insulin in an insulin pump. 
• Do not change your brand, type and dosage of insulin without consulting your doctor.
• Maintain consistency and use this medication regularly to get the best results. 
• Monitor your blood sugar regularly and share the report with your doctor to help them determine your correct dosage. 
• Properly discard the used and outdated medications.
• Store the medicine in a dry and dark place and replace the cap afterward. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Novomix Work?

Novomix combines two insulin preparations, Insulin Aspart and Insulin Aspart Protamine, in different proportions, such as 70/30, 30/70 and 50/50. When both are combined, the patient gets a swift effect lasting several hours a day. Novomix 30 is suitable for patients over ten and helps manage their blood glucose levels by providing consistent, long-term control of blood sugar levels. On the other hand, both Novomix 50 and Novomix 70 are prescribed for patients over 18. It offers a tailored option for diabetes care. The mechanism of action of Novomix is slightly different from that of naturally produced insulin by the body. It gets absorbed by the bloodstream quicker than the natural insulin. It helps glucose enter the cells in your bloodstream, which you utilize for energy. 

Important Safety Information

Side Effects

Common side effects of Novomix may include: 

• Low blood sugar level
• Injection site reaction
• Weight gain 
• Rashes 
• Itching
• Nausea 
• Diarrhea 
• Headache 
• Swelling in hands and legs

Mild Side Effects of Novomix may include:

• Blurred vision
• Mild allergic reaction
• Lipodystrophy
• Edema 
• Rapid heartbeat 
• Confusion

Serious Side Effects of Novomix may include:

• Severe hypoglycemia
• Hypokalemia
• Severe allergic reaction
• Seizures 
• Loss of consciousness 

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings 

• Novomix is for subcutaneous use only. Do not inject it into a vein or muscle, as it may result in severe hypoglycemia. 
• Do not use Novomix in insulin infusion pumps.
• Hypoglycemia is the most common adverse side effect of Novomix. Look for signs and symptoms of low blood sugar. If left untreated, it may lead to life-threatening conditions such as seizures, coma and death. 
• Inadequate intake of insulin and discontinuation of treatment can cause hyperglycemia, which may further lead to a potentially lethal state of diabetic ketoacidosis if not treated.  
• Constantly rotate the injection spots to reduce the chances of injection site reactions such as itching, rashes, lumps and pits under your skin.
• Novomix should not be used in combination with pioglitazone as it may cause heart failure. 

Precautions

• Before taking Novomix, let your doctor know if you have an allergy to it or any other insulin or if you are allergic to anything else. 
• Before starting to use this medication, tell your doctor about your medical history, especially if you have problems related to your kidney, liver or heart. 
• You should not use Novomix if you have severe hypoglycemia. 
• Hypoglycemia may cause blurred vision, dizziness and confusion, so you should not drive, use heavy machinery and indulge in activities that require concentration unless you determine how insulin affects you. 
• The insulin dosage depends upon the patient’s need, condition, age and response to treatment. 
• Do not consume alcohol while receiving treatment of Novomix, as it may affect how the medication reacts to your body.
• Before having any major surgery, including dental surgery, let your doctor or dentist know all the medications you are using. This includes all prescription, over-the-counter drugs, and herbal supplements you’re currently taking. 
• Let your doctor know if you are pregnant, planning to get pregnant, or breastfeeding a baby. You may need to adjust your insulin dosage and diet to manage your blood sugar levels. 

Contraindications 

• During episodes of hypoglycemia
• In patients with known hypersensitivity to Novomix or any of its ingredients. 

Missed Dose

• It is crucial to take doses of Novomix regularly and around the same time daily to maintain a consistent blood sugar level throughout the day. 
• If you missed a dose of novomix, you should check your blood sugar level and determine accordingly. 
• If the blood sugar levels are satisfactory, you can skip the missed dose, take the next dose, and continue taking your medication as scheduled. 
• If the blood sugar levels are high, take it as soon as possible. 
• However, if it is almost time for your next dose, you may skip the missed dose and take the next dose of Novomix as per your dosing schedule. 
• You can try setting a reminder on your phone to avoid missing doses.
• To maintain consistency and help you remember, try to take the medication around the same time every day. 

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

Overdose

For safe and efficient use, taking the medication as directed by your doctor is essential. If you take Novomix more than recommended, you may have hypoglycemia. Symptoms of low blood sugar include dizziness, unusual tiredness, headache, confusion and drowsiness. Untreated hypoglycemia may lead to seizure, coma and death, so it is crucial to control it within time. If someone has overdosed on the medication and is having severe symptoms such as unconsciousness, trouble breathing, seizure, or can’t be woken up, immediately seek medical assistance. You can call 911 or head to the nearest emergency room. Mild episodes of hypoglycemia can be treated by giving the patient oral glucose or sugary products. However, severe episodes of hypoglycemia may be treated by administration of glucose intravenously or subcutaneously by a trained person or healthcare professional. A patient at risk of hypoglycemia needs to carry sugar-containing products with them at all times. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

Storage

• Unopened Novomix vials may be kept in the refrigerator. But do not allow it to freeze. 
• Do not use frozen insulin. Discard it properly and get a new one from your pharmacist. 
• Opened and in-use novomix vials may be kept at room temperature for up to four weeks. 
• Keep Novomix in its original container, away from excess heat, direct sunlight and moisture. 
• Do not keep insulin in the bathroom or contact with other medications. 
• Keep all insulins, including Novomix, in a safe place, away from the reach and sight of children and pets. 
• Do not reuse or share needles. Replace them after use and discard the old ones safely. 
• You should discard pens, cartridges and needles in a sharps container. 
• If you do not have a sharps container, you can use a container made of hard plastic and a tightly fitting lid. 
• Do not keep medicines that are outdated or no longer needed. 
• For more guidance on properly discarding the medication, contact your healthcare provider or local waste disposal company. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Novomix Interactions

• ACE inhibitors 
• antipsychotics 
• basiliximab
• buserelin
• beta-agonists 
• beta-blockers 
• birth control pills
• diuretics 
• chloroquine
• clarithromycin
• corticosteroids 
• danazol
• decongestants 
• diabetes medications 
• disopyramide
• epinephrine
• estrogens 
• everolimus
• glucagon
• goserelin
• hepatitis C antivirals 
• HIV protease inhibitors 
• other insulins
• lanreotide
• MAO inhibitors 
• mifepristone
• niacin
• nilotinib
• octreotide
• pasireotide
• pegvisomant
• progestins 
• quinine
• quinolone antibiotics 
• salicylates 
• selective serotonin reuptake inhibitors 
• somatropin
• sulfa antibiotics 
• sunitinib
• tacrolimus
• testosterone
• thyroid replacement therapy
• tramadol
• venetoclax
• Vorinostat

[Note: This isn’t a complete list, and there could be other drugs that interact with Novomix. Tell your doctor about prescription, over-the-counter medicines, and herbal products.]

Novomix Alternatives 

• Humalog (insulin lispro)
• Lantus (insulin glargine)
• Novorapid (insulin aspart)
• Apidra (insulin glulisine)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions 

1. Can NovoMix Flexpen be used for type 1 diabetes?

Yes, NovoMix 30 treats both type 1 and 2 diabetes. It works for a wide range of diabetics since it contains rapid-acting and intermediate-acting insulins. However, a doctor should establish NovoMix 30 dosage and administration according to the patient’s diabetes type and medical history.

2. Is it safe to use NovoMix Insulin during pregnancy?

Diabetic women who are pregnant should talk to their doctor about how to use insulin, including NovoMix 30 before they start using it. By talking to a doctor or nurse, you can make sure that the treatment plan fits the wants and concerns of pregnancy. They will give you personalized advice on how to control your blood sugar levels during this important time.

3. How quickly does NovoMix 30 Penfill start working after an injection?

As soon as NovoMix 30 is injected, it begins to work within 10 to 20 minutes. Individuals with diabetes have a reliable option for regulating blood sugar due to the relatively rapid onset of the drug.

4. What should I do if I experience an allergic reaction to NovoMix 30?

You must seek medical attention right away if you experience any side effects related to NovoMix 30, such as difficulty breathing or swelling of the face, lips, tongue, or throat. In order to ensure your safety and receive prompt and appropriate medical care, this step is crucial.

Our Guarantee

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