Empagliflozin
Jardiance
Jardiance is an FDA-approved antidiabetic medication used to treat individuals with type 2 diabetes mellitus. The prescription medication contains Empagliflozin as its main ingredient, which belongs to the class of sodium-glucose co-transporter 2 inhibitors. It comes in the form of a tablet that is to be taken orally once daily in the morning, with or without food. It has two strengths: 10 mg and 25 mg. The dosage of the medication depends upon the patient’s condition and response to treatment. Jardiance should not be used in patients with severe kidney impairment, end-stage kidney disease, or those on dialysis. Before using Jardiance to treat your condition, consult your doctor and discuss the potential risk and benefits associated with the medication and ways to overcome and prevent them.
Product Overview
Jardiance Tablet is a medication used to treat type 2 diabetes mellitus, either alone or in combination with other diabetes medicines. It contains the active ingredient empagliflozin, which helps control high blood sugar levels commonly seen in diabetes. By assisting the kidneys in removing excess sugar from the body through urine, Jardiance reduces the risk of serious complications such as kidney damage, blindness, and heart disease associated with diabetes.
The recommended dosage for Jardiance is typically 10 mg once daily, taken in the morning with or without food. However, the dose may vary based on individual needs and response to treatment, as determined by a healthcare professional. Jardiance is suitable for adults and children above ten years of age, under the supervision of a doctor.
Common side effects of Jardiance may include nausea, urinary tract infections, increased thirst, and joint pain. It is important to maintain good hydration to prevent dehydration, a possible side effect of the medication. Jardiance should not be used in patients with severe kidney impairment, end-stage kidney disease, or those on dialysis. If a dose of Jardiance is missed, it should be taken as soon as remembered unless it is almost time for the next dose. In case of an overdose, immediate medical attention is advised. Jardiance should be stored in its original container at a controlled temperature, away from direct sunlight and moisture. It is crucial to follow the guidance of a healthcare provider when taking Jardiance to manage diabetes effectively and safely.
Uses
Targeted Treatment
- It is used to treat type 2 diabetes mellitus.
Benefits
- When used in combination with improved diet and exercise, it improves the levels of blood sugar in individuals with type 2 diabetes mellitus.
- It may also be used for adults with chronic kidney disease who have a risk of disease progression.
- It reduces the risk of hospitalization and death in adults with cardiovascular disease in addition to type 2 diabetes.
- It reduces the risk of end-stage kidney disease, hospitalization and death in certain individuals with heart failure.
- It lowers blood sugar levels by helping the kidneys increase the amount of glucose passing into the urine.
- It may also be prescribed off-label for weight loss.
[Note: Do not take Jardiance without consulting your doctor. They will determine whether you need this medication based on your conditions.]
Jardiance Dosage
Forms & Strengths
Form: Oral tablet
Strength: It is available in the following two strengths:
- Jardiance 10 mg tablet
- Jardiance 25 mg tablet
Recommended Dosages
For Individuals With Type 2 Diabetes Mellitus
- Initial daily dose (Adult): 10 mg, to be taken in the morning daily, with or without food.
- Initial daily dose (Children above ten years): 10 mg, to be taken in the morning daily, with or without food.
- Maximum daily dose: 25 mg once every day when the patient seems to tolerate the dose of 10 mg per day.
For Individuals With Cardiovascular Disease Risk Reduction
- Recommended Dosage: 10 mg, to be taken in the morning daily, with or without food.
For Individuals With Chronic Kidney Disease
- Recommended Dosage: 10 mg, to be taken in the morning daily, with or without food.
[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Take It?
- Before using Jardiance for the first time and after each time you get a refill, carefully read the Patient Information Leaflet and follow the instructions given by your doctor for a safe and effective use of the medication.
- Take this medication as advised by your doctor in the dose and duration recommended. Do not chew, break or crush the Jardiance 10 mg tablet. Swallow it as a whole.
- If you have a problem in taking this tablet as a whole, talk with your doctor or pharmacist to know what should be done.
- You can take this medicine with or without food, once daily in the morning.
- For the best results and to maintain consistency, try to take this medicine at the same time every day.
- The dosage of the medicine is based on the patient’s age, condition, needs and response to treatment.
- Make sure to intake more fluid and stay hydrated to prevent dizziness, fatigue and weakness.
- Maintain genital hygiene to prevent infections in the penis or vagina.
- Let your doctor know if your condition does not improve or if it worsens.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Jardiance Work?
Jardiance (empagliflozin) is an antidiabetic medication that belongs to the class of drugs known as sodium-glucose cotransporter-2 inhibitors. Jardiance starts to work within 30 to 60 minutes of taking. It is usually used alone or in combination with other diabetes medications to manage blood sugar levels in adults and children above ten years of age. By controlling blood sugar levels, it helps in preventing serious complications of diabetes such as nerve problems, eye, kidney damage, sexual dysfunction and loss of limbs. It works by blocking the action of SGLT-2 proteins that are found in the renal tubules of the kidneys. It prevents the reabsorption of glucose back into the bloodstream. As a result, more glucose is excreted in the urine, leading to lower blood sugar levels.
Important Safety Information
Side Effects
Common side effects of Jardiance may include:
- Urinary tract infection
- Vaginal yeast infection
- Frequent urination
- Increased thirst
- Hypoglycaemia
- Joint pain
- Weight gain
Mild side effects of Jardiance may include:
- Mild allergic reaction
- Nausea
- Abdominal pain
- Trouble breathing
- Dehydration
Adverse side effects of Jardiance may include:
- Hypotension. Symptoms may include:
- Lightheadedness
- Dizziness
- Clammy skin
- Unconsciousness
- Depression
- Kidney damage. Symptoms may include:
- Decreased urination
- Unusual tiredness
- Swelling in legs and ankles
- Confusion
- Severe urinary tract infections
- Genital yeast infections
- Severe allergic reactions
- Ketoacidosis
- Fournier’s gangrene
- Increased Low-Density Lipoprotein Cholesterol
[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]
Warnings
- Jardiance is not recommended to treat patients with type 1 diabetes or diabetic ketoacidosis.
- It is not indicated for use in adults with type 2 diabetes mellitus who have end-stage kidney disease, or severe kidney problems.
- Jardiance 10 mg tablets should not be used in patients on dialysis.
- Jardiance may cause severe infection in the genital area. Keep your genital/ rectal area clean and hygienic to avoid risks of infection in the penis or vagina. Call your doctor immediately if you have a burning sensation, itching, pain, tenderness, odor, redness or swelling of your genital area.
- Discontinue taking this medication and contact your doctor at once if you have a fever or if you are not feeling well.
- Taking Jardiance can make you feel dehydrated or urinate more often. Make sure to intake more fluid and stay hydrated to prevent dizziness, fatigue and weakness.
- Let your doctor know if you are sick with diarrhea, vomiting, or if you are consuming less food than usual.
Precautions
- It is considered unsafe to consume alcohol while taking Jardiance. You should also avoid taking medications that contain alcohol as it may cause unwanted side effects.
- Jardiance is not recommended for use in pregnant women as it may cause fetal harm. Before taking the medication, let your doctor know if you think you may be pregnant or planning to become pregnant.
- You should not use Jardiance while you are breastfeeding a baby as the medication may pass into the breastmilk and cause harm to the baby.
- Jardiance may affect your vision and concentration. Do not drive, operate heavy machinery or indulge in activities that require your attention unless you determine how the medication affects you.
- Jardiance should be used with caution in patients with liver and kidney problems. Such patients may require an adjustment in their dosage and diet.
- Do not take Jardiance along with other antidiabetic medications, and do not skip meals or eat less, as it may lead to hypoglycemia.
- If you experience symptoms of low blood sugar, take sugar-containing food or fruit juice.
- You should monitor your blood sugar levels on a regular basis while you are taking Jardiance and share the report with your doctor to help them determine the correct dosage for you.
- Before using Jardiance, let your doctor know if you are allergic to empagliflozin or any of the inactive ingredients present in the medication, as it may cause allergic reactions or some other problem.
- If you are planning to have surgery, including a dental procedure, let your doctor or dentist know all the medicines you are taking. This includes all prescription medications, over-the-counter drugs and herbal supplements you take.
- You may have problems in controlling your blood sugar levels if your body is under stress, due to illness, surgery, exercise or infection. Monitor your blood sugar levels regularly and adjust your dosage and diet according to the doctor’s recommendations.
- The side effects associated with the use of Jardiance usually go away within a couple of days, but if they become bothersome or persist, contact your doctor and discuss your symptoms with them.
- Do not give Jardiance to anyone, even if they have the same symptoms as you.
Contraindications
- Allergy to Empagliflozin or any of the active ingredients present in Jardiance.
- Known hypersensitivity to empagliflozin and any inactive ingredients.
- Severe renal impairment
- End-stage renal disease
- Undergoing dialysis
Missed Dose
- If you missed a dose of Jardiance, you should take it as soon as possible.
- However, if it is almost time for your next dose, you may skip the missed dose of Jardiance and continue as per your regular dose.
- If you still can’t determine when to take the missed dose, call your doctor or healthcare provider.
- Do not take two or extra doses of the same medication to compensate for the missed dose.
- To further avoid missing doses, try to set a reminder on your phone.
[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]
Overdose
Do not take Jardiance more than recommended. If someone has overdosed on the medication, seek immediate medical attention, even in the absence of symptoms. If the patient has passed out, has difficulty breathing or can’t be woken up, immediately call the Poison Helpline, 911 or head to the nearest emergency room. Side effects caused by overdose are as follows:
- Kidney damage
- Hypoglycemia
- Ketoacidosis
[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]
Storage
- Store Jardiance in its original container at a controlled temperature.
- Keep the medication away from direct sunlight, excess heat and moisture.
- Do not keep Jardiance in the bathroom.
- Keep all antidiabetic medications, including jardiance away from the sight and reach of children.
- Do not keep medicines that are outdated or no longer needed.
- Do not throw the medicine in wastewater or your household garbage bin.
- Do not flush the medicine unless instructed to do so.
- For more information on proper disposal of the medicine, contact your pharmacist or local waste disposal company.
[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]
Jardiance Interactions
- ACE inhibitors
- Alcohol
- Angiotensin receptor blockers
- Diuretics
- Insulin such as:
- insulin lispro
- insulin aspart
- regular insulin
- insulin glulisine
- Beta-blockers such as:
- Metoprolol
- Timolol
- Propranolol
- Certain antidiabetics such as:
- Nateglinide
- Glyburide
- Tolbutamide
- Glipizide
- Glimepiride
- DPP-4 inhibitors
- GLP-1 receptor agonists
- Lithium
- Insulin-secretagogues
- Nonsteroidal anti-inflammatory drugs such as ibuprofen.
[Note: This isn’t a complete list, and there could be other drugs that interact with Jardiance. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
Jardiance Alternatives
- Invokana (canagliflozin)
- Farxiga (dapagliflozin)
- Steglatro (ertugliflozin)
- Metformin
- Trulicity (dulaglutide)
- Byetta (exenatide)
- Victoza (liraglutide)
- Adlyxin (lixisenatide)
- Ozempic (semaglutide)
- Januvia (sitagliptin)
- Diabeta (glyburide)
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Frequently Asked Questions
1. What is Jardiance used for?
Jardiance is used to treat type 2 diabetes mellitus. It helps control high blood sugar levels, reducing the risk of serious complications like kidney damage and blindness. It reduces the risk of hospitalization and death in adults with heart failure, cardiovascular disease in addition to type 2 diabetes.
2. How should I take Jardiance?
Jardiance should be taken as prescribed by your doctor, usually once daily in the morning with or without food. It is important to take it at the same time every day. Do not chew, break, or crush the tablet. Swallow it whole. Jardiance can make you feel dehydrated. Make sure to intake more fluid and stay hydrated to prevent dizziness, fatigue and weakness.
3. What are the side effects of Jardiance?
Common side effects of Jardiance include nausea, frequent urination, increased thirst, urinary tract infections, vaginal yeast infections, joint pain, and hypoglycemia (low blood sugar). It may also cause dehydration, so it is important to drink plenty of fluids and stay hydrated.
4. Can I take Jardiance if I have kidney or liver problems?
Before taking Jardiance, inform your doctor if you have any kidney or liver problems. They will determine if Jardiance is safe for you. It is also important to monitor your blood sugar levels regularly while taking Jardiance.
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